Viral Vectors and Plasmid DNA Manufacturing Market, 2030

DUBLIN, June 14, 2018 /PRNewswire/ --

The "Viral Vectors and Plasmid DNA Manufacturing Market (2nd Edition), 2018-2030" report has been added to's offering.

The Viral Vectors and Plasmid DNA Manufacturing Market (2nd Edition), 2018-2030 report offers a comprehensive study of the current scenario of manufacturing of viral and non-viral vectors that are primarily used for the development of gene therapies and T-cell therapies. The study features an in-depth analysis, highlighting the capabilities of a diverse set of players, covering both contract manufacturers and companies with in-house capabilities.

Genetically modified therapies have emerged as a promising treatment option for various diseases (primarily ones that currently have no cure), including cancers, inherited disorders and certain viral infections. These therapies have demonstrated the potential to treat chronic indications, such as Alzheimer's disease, Parkinson's disease and rheumatoid arthritis, as well. Gene therapies, and other therapies that require genetic modification, involve the introduction of therapeutic DNA / gene of interest into a patient's body / cells. This process is accomplished by the use of vectors. Over the last few decades, various viral and non-viral vectors have been developed, optimized and standardized for this purpose.

Currently, the most popular viral vectors, on the basis of their use in active clinical trials, are those based on AAV, adenovirus, lentivirus and retrovirus. On the other hand, among non-viral gene delivery tools, plasmid DNA has emerged as the preferred option. Plasmid DNA is also used in the development and production of viral vectors and DNA vaccines. Recent advances have led to the emergence of several other innovative viral / non-viral gene delivery approaches that are being utilized for development of various therapies that require gene modification.

Overall, eleven genetically modified therapies have been approved so far; these are (in the order of approval, most recent first) LUXTURNA, YESCARTA, Kymriah, INVOSSA, Zalmoxis, Strimvelis, Imlygic, Neovasculagen, Rexin-G, Oncorine and Gendicine. Amongst these, YESCARTA and Kymriah are T-cell based gene therapies that were recently approved by the FDA, in October 2017 and August 2017, respectively.

In addition, over 430 gene therapy candidates are presently in different stages of clinical development, for which over 500 clinical studies are currently underway in various regions across the globe. The growing number of gene therapy candidates, coupled with their rapid progression through various phases of clinical development, is expected to continue to create an increasing demand for vectors.

Key Topics Covered:

1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines


3.1. Chapter Overview
3.2. Viral and Non-Viral Methods of Gene Transfer
3.3. Viral Vectors for Genetically Modified Therapies
3.4. Type of Viral Vectors
3.4.1. Adeno-associated Viral Vectors
3.4.2. Adenoviral Vectors
3.4.3. Lentiviral Vectors
3.4.4. Retroviral Vectors
3.4.5. Other Viral Vectors Alphavirus Foamy Virus Herpes Simplex Virus Sendai Virus Simian Virus Vaccinia Virus
3.5. Types of Non-Viral Vectors
3.5.1. Plasmid DNA
3.5.2. Liposomes, Lipoplexes and Polyplexes
3.5.3. Oligonucleotides
3.5.4. Other Non-Viral Vectors
3.5.5. Methods of Gene Delivery using Non-Viral Vectors: Methods of Transfection Biolistic Methods Electroporation Receptor Mediated Gene Delivery Gene Activated Matrix (GAM)
3.6. Applications of Viral and Non-Viral Vectors
3.6.1. Type of Therapy Gene Therapy Vaccinology
3.6.2. Current Trends in Vector Development / Manufacturing Vector Engineering: Synthetic and Next Generation Vectors Cargo Engineering

4.1. Chapter Overview
4.2. Viral Vectors Manufacturers: Overall Market Landscape
4.2.1. Distribution by Year of Establishment
4.2.2. Distribution by Location of Manufacturing Facility
4.2.3. Distribution by Type of Organization
4.2.4. Distribution by Purpose of Production
4.2.5. Distribution by Type of Vector
4.2.6. Distribution by Scale of Production

5.1. Chapter Overview
5.2. Plasmid DNA Manufacturers: Overall Market Landscape
5.2.1. Distribution by Year of Establishment
5.2.2. Distribution by Location of Manufacturing Facility
5.2.3. Distribution by Type of Organization
5.2.4. Distribution by Purpose of Production
5.2.5. Distribution by Scale of Production

6.1. Chapter Overview
6.2. Aldevron
6.3. BioReliance / SAFC Commercial (Merck KGaA)
6.4. bluebird bio
6.5. Brammer Bio
6.6. FUJIFILM Diosynth Biotechnologies
6.7. MassBiologics
6.8. Novasep
6.9. Spark Therapeutics
6.10. Vigene Biosciences

7.1. Chapter Overview
7.2. Biovian
7.3. Cell and Gene Therapy Catapult
7.4. Cobra Biologics
7.5. FinVector
7.6. Kaneka Eurogentec
7.7. Lonza
7.8. MolMed
7.9. Oxford BioMedica
7.10. Richter-Helm
7.11. Sanofi (CEPiA, Sanofi Pasteur, Genzyme)
7.12. uniQure
7.13. VIVEbiotech

8.1. Chapter Overview
8.2. Wuxi AppTec
8.3. Other Key Players

9.1. Chapter Overview
9.1.1. Alphavirus Based Vectors
9.1.2. Bifidobacterium longum (B. longum) Based Vectors
9.1.3. Cytomegalovirus (CMV) Based Vectors
9.1.4. Listeria Monocytogenes Based Vectors
9.1.5. Minicircle DNA Based Vectors
9.1.6. Myxoma Virus Based Vectors
9.1.7. Self-Complementary Vectors
9.1.8. Sendai Virus Based Vectors
9.1.9. Sleeping Beauty Transposons

10.1. Chapter Overview
10.2. Partnership Models
10.3. Viral Vectors and Plasmid DNA Manufacturing: Recent Collaborations and Partnerships
10.4. Other Collaborations

11.1. Chapter Overview
11.2. Viral Vectors and Plasmid DNA Manufacturers: Competitive Landscape by Vector Type, Scale of Operation and Purpose of Manufacturing
11.3. Viral Vectors and Plasmid DNA Manufacturers: Logo Landscape by Vector Type and Size of the Company
11.4. Viral Vectors and Plasmid DNA Manufacturers: Prominent Geographical Hubs by Type of Manufacturer
11.4.1. Contract Manufacturers
11.4.2. In-House Manufacturers
11.5. Viral Vectors and Plasmid DNA Manufacturers: Distribution by Location of Manufacturing Facility and Type of Vector
11.5.1. AAV Vector Manufacturers
11.5.2. Adenoviral Vector Manufactures
11.5.3. Lentiviral Vector Manufactures
11.5.4. Retroviral Vector Manufactures
11.5.5. Plasmid DNA Manufactures

12.1. Chapter Overview
12.2. Viral Vectors and Plasmid DNA Based Therapies (Genetically Modified Therapies): Factors Contributing to Higher Price Tags
12.3. Viral Vectors and Plasmid DNA Prices
12.3.1. Based on Expert Opinions
12.3.2. Based on Manufacturing Cost Based on Technology Used Based on Scale of Manufacturing Based on Client Type
12.3.3. Price Points on Different Types of Vectors
12.4. Concluding Remarks

13.1. Chapter Overview
13.2. Key Assumptions and Methodology
13.3. Viral Vectors Manufacturing: Installed Global Capacity
13.4. Plasmid DNA Manufacturing: Installed Global Capacity
13.5. Viral Vectors and Plasmid DNA Manufacturing: Overall Installed Global Capacity

14.1. Chapter Overview
14.2. Scope of the Forecast
14.3. Forecast Methodology
14.4. Input Tables and Key Assumptions
14.5. Overall Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030
14.5.1. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Vector Type (AAV, Adenoviral, Lentiviral, Retroviral, Plasmid DNA, Other Viral Vectors)
14.5.2. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Application (Gene Therapy / T-cell Therapy)
14.5.3. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Therapeutic Area (Oncology, Inflammation & Immunology, Ophthalmology, Metabolic Disorders, Cardiovascular Disorders, Others)
14.5.4. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Scale of Operation (Clinical / Commercial)
14.5.5. Viral Vectors and Plasmid DNA Manufacturing Market, 2018-2030: Distribution by Geography (North America, Europe, Asia-Pacific, RoW)
14.6. Opportunity from Commercial Products
14.6.1. AAV Vectors
14.6.2. Adenoviral Vectors
14.6.3. Lentiviral Vectors
14.6.4. Retroviral Vectors
14.6.5. Plasmid DNA
14.6.6. Other Viral Vectors
14.7. Opportunity from Clinical Products
14.7.1. AAV Vectors
14.7.2. Adenoviral Vectors
14.7.3. Lentiviral Vectors
14.7.4. Retroviral Vectors
14.7.5. Plasmid DNA
14.7.6. Other Viral Vectors

15.1. Chapter Overview
15.2. Viral Vectors and Plasmid DNA: Drivers and Challenges
15.2.1. AAV Vectors
15.2.2. Adenoviral Vectors
15.2.3. Lentiviral Vectors
15.2.4. Retroviral Vectors
15.2.5. Plasmid DNA
15.3. Additional Information

16.1. Chapter Overview
16.2. Seniority Level of Respondents
16.3. Type of Vector
16.4. Scale of Production
16.5. Vector Stabilization Technology
16.6. In-house / Contract Operations

17.1. Increasing Efforts Related to Development of Advanced Therapy Candidates that Require Genetic Manipulation have Led to a Rise in the Demand for Vectors
17.2. Manufacturing Efforts in this Domain Feature the involvement of Several Industry Players and Academic Institutes; Many Startups have also been Established in the Recent Past
17.3. Given Regulatory Stringencies and Exorbitant Costs Associated with Developing In-House Facilities, Outsourcing Has Emerged as a Reliable Option for Vector Manufacturing
17.4. Manufacturers Have Established their Presence Across Different Regions; the US and EU have Emerged as Key Hubs
17.5. Several Efforts to Develop Innovative Technology Platforms are Underway, and are Expected to Drive the Production of Efficient, Safe and Stable Vectors
17.6. Novel Viral and Bacterial Strains are Being Investigated as Vectors for use in Genetically Modified Therapies / Vaccines
17.7. The Partnership Activity in this Domain is on the Rise as Companies Actively Collaborate to Develop Innovative Manufacturing Technology Platforms
17.8. Driven by a Rapidly Evolving Pipeline of Therapies, the Market is Anticipated to Grow at an Accelerated Pace over the Coming Decade

18. Executive Insights
18.1. Chapter Overview
18.2. Amsterdam BioTherapeutics Unit (AmBTU)
18.2.1. Overview of the Organization
18.2.2. Interview Transcript: Joost van den Berg, Director
18.3. ACGT
18.3.1. Overview of the Organization
18.3.2. Interview Transcript: Semyon Rubinchik, Scientific Director
18.4. CEVEC Pharmaceuticals
18.4.1. Overview of the Organization
18.4.2. Interview Transcript: Nicole Faust, Chief Executive Officer & Chief Scientific Officer
18.5. Clean Cells
18.5.1. Overview of the Organization
18.5.2. Interview Transcript: Laurent Ciavatti, Business Development Manager, Olivier Boisteau, President / Co-Founder and Xavier Leclerc, Head of Gene Therapy
18.6.1. Overview of the Organization
18.6.2. Interview Transcript: Interview Transcript, Colin Lee Novick, Managing Director
18.7. Delphi Genetics
18.7.1. Overview of the Organization
18.7.2. Interview Transcript: Cedric Szpirer, Executive & Scientific Director
18.8. GEG Tech
18.8.1. Overview of the Organization
18.8.2. Interview Transcript: Nicolas Grandchamp, R&D Leader
18.9. MGH Viral Vector Development Facility, Massachusetts General Hospital
18.9.1. Overview of the Organization
18.9.2. Interview Transcript: Bakhos A Tannous, Director
18.10. Novasep
18.10.1. Overview of the Organization
18.10.2. Interview Transcript: Alain Lamproye, President of Biopharma Business Unit
18.11. Richter-Helm
18.11.1. Overview of the Organization
18.11.2. Interview Transcript: Astrid Brammer, Senior Manager Business Development
18.12. Plasmid Factory
18.12.1. Overview of the Organization
18.12.2. Interview Transcript: Marco Schmeer, Project Manager and Tatjana Buchholz, Marketing Manager
18.13. Vigene Biosciences
18.13.1. Overview of the Organization
18.13.2. Interview Transcript: Jeffrey Hung, Chief Commercial Officer
18.14. Waisman Biomanufacturing
18.14.1. Overview of the Organization
18.14.2. Interview Transcript: Brian M Dattilo, Business Development Manager

Companies Mentioned

    --  4D Molecular Therapeutics
    --  AbbVie
    --  Abeona Therapeutics
    --  Acucela
    --  Adaptimmune Therapeutics
    --  Addgene
    --  Aduro Biotech
    --  Advanced BioScience Laboratories (ABL)
    --  Advanced Biotherapeutics Consulting
    --  Advaxis
    --  Advent
    --  Adverum Biotechnologies
    --  Agenzia Italiana del Farmaco
    --  Agilent Technologies
    --  Agilis Biotherapeutics
    --  Aldevron
    --  Allele Biotechnology
    --  Alma Bio Therapeutics
    --  AlphaVax
    --  Althea Technologies
    --  American Gene Technologies
    --  Amgen
    --  AMSBIO
    --  Amsterdam BioTherapeutics Unit
    --  Anaeropharma Science
    --  Applied Biological Materials
    --  Applied Genetic Technologies (AGTC)
    --  Applied Viromics
    --  ARCO Design/Build
    --  Areta International
    --  Asklepios BioPharmaceutical
    --  Atlantic Bio GMP
    --  ATVIO Biotech
    --  Audentes Therapeutics
    --  Autolus
    --  AveXis
    --  Avista Capital Partners
    --  Bamboo Therapeutics
    --  Batavia Biosciences
    --  Bavarian Nordic
    --  Baxter
    --  Beckman Research Institute
    --  Belfer Gene Therapy Core Facility, Cornell University
    --  Benitec Biopharma
    --  BioCancell
    --  Biogen
    --  Biomay
    --  Biomiga
    --  BioReliance
    --  Biotec Services International
    --  Biotechnology Department of San Raffaele
    --  Biotie Therapies
    --  Bioverativ
    --  BioVex
    --  Biovian
    --  Blue Sky BioServices
    --  bluebird bio
    --  B-MoGen Biotechnologies
    --  Boehringer Ingelheim
    --  Brammer Bio
    --  BRC Clinical Research Facility and Cell Therapy Unit, King's College
    --  Brewin Dolphin
    --  Bristol-Myers Squibb
    --  Brookside Capital
    --  California Institute for Regenerative Medicine
    --  California Institute of Technology
    --  Calimmune
    --  Cancer Research UK
    --  Capsugel
    --  Carnegie Institution for Science
    --  Celgene
    --  Cell and Gene Therapy Catapult
    --  Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering
        Cancer Center
    --  Celladon
    --  Cellectis
    --  Cellular Biomedicine Group
    --  Center for Biomedicine & Genetics, City of Hope
    --  Center for Cell and Gene Processing, Takara Bio
    --  Center for Cell and Gene Therapy, Baylor College of Medicine
    --  CEPiA Sanofi
    --  CEVEC Pharmaceuticals
    --  Chiesi Farmaceutici
    --  Children's GMP (St. Jude Children's Research Hospital)
    --  Children's Hospital of Philadelphia
    --  CIEMAT
    --  Cincinnati Children's Hospital Medical Center
    --  Clean Cells
    --  Clinical Biotechnology Centre, NHS Blood and Transplant
    --  Clinical Vector Production Core, University of Pittsburgh
    --  Cobra Biologics
    --  CombiGene
    --  Core Facility for Therapeutic Vectors, Institute of Medical Science
        Research Hospital
    --  Cranfield University
    --  Creative Biogene
    --  Creed Commercial Development
    --  Deerfield Management
    --  Delphi Genetics
    --  Department of Neuroscience, University of Minnesota
    --  Desktop Genetics
    --  DNAtrix
    --  Elixirgen Scientific
    --  Epeius Biotechnologies
    --  EUFETS
    --  Eurofins Genomics
    --  European Society of Gene and Cell Therapy
    --  Finnish Bioindustries
    --  FinVector
    --  Fisher BioServices
    --  Five Prime Therapeutics
    --  FKD Therapies
    --  Florida Biologix
    --  Fondazione Telethon
    --  Foundation Fighting Blindness
    --  Fraunhofer Institute for Toxicology and Experimental Medicine
    --  Freeline Therapeutics
    --  FUJIFILM Diosynth Biotechnologies
    --  GEG Tech
    --  Genable Technologies
    --  Gene and Cell Therapy Lab, Institute of Translational Health Sciences
    --  Gene Editing and Viral Vector Core, City of Hope
    --  Gene Medicine Japan
    --  Gene Therapy Research Institute
    --  Gene Transfer Vector Core, Schepens Eye Research Institute
    --  Gene Transfer, Targeting and Therapeutics Core, Salk Institute for
        Biological Studies
    --  GeneCure Biotechnologies
    --  GeneDetect
    --  GeneImmune Biotechnology
    --  Genethon
    --  GENEWIZ
    --  GenIbet Biopharmaceuticals
    --  GenScript
    --  GenVec
    --  Genzyme
    --  GIGA Institute, Liege Universite
    --  Gilead Sciences
    --  GlaxoSmithKline
    --  Green Cross LabCell
    --  GSEx, Robinson Research Institute, The University of Adelaide
    --  Guy's Hospital, London
    --  Hercules Capital
    --  Hong Kong Institute of Biotechnology
    --  Hookipa Biotech
    --  Hope Center Viral Vectors Core, Washington University School of Medicine
    --  Horizon Discovery
    --  Hospital de Sant Pau
    --  Human Stem Cells Institute
    --  ID Pharma
    --  Immune Design
    --  Immune Technology
    --  ImmunoGenes
    --  Immunomic Therapeutics
    --  Inbiomed
    --  Indiana University Vector Production Facility
    --  Instituto de Tecnologia Qumica e Biolgica Antnio Xavier
    --  Intrexon
    --  InvivoGen
    --  IPPOX Foundation
    --  IQVIA Stem Cell Center
    --  Janelia Research Campus
    --  Janssen
    --  Kalon Biotherapeutics
    --  Kaneka Eurogentec
    --  Kelley School of Business, Indiana University
    --  King's College London, Guy's and St Thomas' NHS Foundation Trust
    --  Kite Pharma
    --  Kolon Life Sciences
    --  Laboratory of Malaria Immunology and Vaccinology
    --  LakePharma
    --  Lentigen
    --  Lentiviral Lab, USC School of Pharmacy
    --  Leuven Viral Vector Core
    --  Lonza
    --  Luminous BioSciences
    --  Lund University
    --  Lysogene
    --  Massachusetts Eye and Ear
    --  Massachusetts Life Science Center
    --  MassBiologics
    --  MaxCyte
    --  Medigene
    --  MeiraGTx
    --  Merck
    --  Merck Serono
    --  Merial
    --  Michael J. Fox Foundation for Parkinson Research
    --  Mila's Miracle Foundation
    --  MilliporeSigma
    --  Ministry of Economy and Competitiveness
    --  Mitsubishi
    --  Molecular Diagnostic Services
    --  MolMed
    --  Myeloma Crowd Research Initiative
    --  NanoCor Therapeutics
    --  Nantes Gene Therapy Institute
    --  National Cancer Institute
    --  National Center for Advancing Translational Sciences
    --  National Human Genome Research Institute
    --  National Institutes of Health
    --  Nature Technology
    --  Naval Medical Research Center
    --  Neuroscience CenterVector Core, Massachusetts General Hospital
    --  Neuroscience Gene Vector and Virus Core, Stanford Medicine
    --  NewLink Genetics
    --  Novartis
    --  Novasep
    --  Ocular Gene Therapy Core, National Eye Institute
    --  Okairos
    --  Omnia Biologics
    --  Orchard Therapeutics
    --  Oxford BioMedica
    --  Oxford Genetics
    --  PacificGMP
    --  Paragon Bioservices
    --  Penn Vector Core, University of Pennsylvania
    --  Pfizer
    --  PharmaChem Technologies
    --  Pinchal & Company
    --  PlasmidFactory
    --  Powell Gene Therapy Center, University of Florida
    --  Protein Sciences
    --  Provecs Medical
    --  Puresyn
    --  Raymond G. Perelman Center for Cellular and Molecular Therapeutics,
        Children's Hospital of Philadelphia
    --  Rayne Cell Therapy Suite, King's College London
    --  Renova Therapeutics
    --  Richter-Helm BioLogics
    --  RIKEN BioResource Research Center
    --  Roche
    --  Rock Springs Capital
    --  Rocket Pharmaceuticals
    --  SAB-Technology
    --  SAFC
    --  Sanofi
    --  Sartorius Stedim Biotech
    --  Scancell
    --  Selecta Biosciences
    --  Shanghai Sunway Biotech
    --  Shenzhen SiBiono GeneTech
    --  SignaGen Laboratories
    --  SillaJen
    --  Sino Biological
    --  SIRION Biotech
    --  Sofinnova Ventures
    --  Spark Therapeutics
    --  St Thomas' NHS Foundation Trust
    --  Stanford University
    --  Stevenage Bioscience Catalyst
    --  Strathmann Biotec
    --  Stratophase
    --  Synpromics
    --  Synthace
    --  Synthetic Genomics
    --  System Biosciences
    --  T. Rowe Price Associates
    --  Takara Bio
    --  Tecrea
    --  Texas A&M University
    --  The Finnish Fair Foundation
    --  The Goldyne Savad Institute of Gene Therapy, Hadassah Medical
    --  The Human Gene and Cell Therapy Center, Akdeniz University
    --  The Jarvis Lab
    --  The Wellcome Trust
    --  TheraBiologics
    --  Therexsys
    --  Thermo Fisher Scientific
    --  TissueGene
    --  Touchlight Genetics
    --  Transgene
    --  Treeway
    --  Twist Bioscience
    --  TxCell
    --  UAB Vector Production Facility
    --  uniQure
    --  Unit Biotech & ATMP's, University Medical Center Groningen
    --  UniTech Pharma
    --  University of Florida
    --  University of Iowa Research Foundation
    --  University of Lige
    --  University of Massachusetts Medical School System
    --  University of Oxford Clinical Biomanufacturing Facility
    --  University of Virginia School of Medicine
    --  Vaccibody
    --  Vaccine and Gene Therapy Institute
    --  Valneva
    --  VBI Vaccine
    --  Vectalys
    --  Vector Biolabs
    --  Vector Core / GMP Facility, UC Davis Health
    --  Vector Core of Gene Therapy, Laboratory of Nantes
    --  Vector Core, Harvard Gene Therapy Initiative
    --  Vector Core, Telethon Institute of Genetics and Medicine
    --  Vector Core, University of Michigan Medical School
    --  Vector Core, University of North Carolina
    --  Vecura GMP Laboratory, Karolinska Institutet
    --  VGXI
    --  Vibalogics
    --  Vical
    --  Vigene Biosciences
    --  Viral Gene Transfer Core, Massachusetts Institute of Technology
    --  Viral Vector Core / Clinical Manufacturing Facility, Nationwide
        Children's Hospital
    --  Viral Vector Core, Carver College of Medicine, University of Iowa
    --  Viral Vector Core, Duke University
    --  Viral Vector Core, Emory University School of Medicine
    --  Viral Vector Core, Jenner Institute
    --  Viral Vector Core, Sanford Burnham Prebys Medical Discovery Institute
    --  Viral Vector Core, University of Massachusetts Medical School
    --  Viral Vector Facility, Neuroscience Center Zurich
    --  Viral Vector Production Laboratory, Mayo Clinic Cancer Center
    --  Viral Vector Production Unit, Universitat Autnoma de Barcelona-Vall
        d'Hebrn Institut de Recerca
    --  ViralGEN
    --  ViroMed
    --  Virovek
    --  VirusTech Core Facility, Karolinska Institutet
    --  Vivante GMP Solutions
    --  VIVEbiotech
    --  Voyager Therapeutics
    --  Waisman Biomanufacturing
    --  Wellington Management
    --  Wolfson Gene Therapy Unit, University College London
    --  WuXi AppTec
    --  Xpress Biologics
    --  YPOSKESI
    --  ZIOPHARM Oncology

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