Aug 21, 2018   SOURCE: PR NewsWire

Switching to CRISPR: Detailed Understanding of the Two Major Types of Adaptive Immunity to Cas9 Proteins - Humoral Immunity and Cell-Mediated Immunity

DUBLIN, Aug. 21, 2018 /PRNewswire/ --

The "Switching to CRISPR - Cas Systems from Uncultivated Microbes" report has been added to ResearchAndMarkets.com's offering.

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology is currently the biggest discovery in life science. As a precise gene editing tool, it has been widely used in many areas with a great potential to treat human diseases. While some CRISPR-based therapeutic studies are moving to clinical trials, CRISPR's therapeutic promise was brought into question when some issues were found that could become major obstacles in moving the great genome editing tools to the clinic.

While many groups are actively resolving these obstacles, the significant challenges to minimize the immunological risks and avoid potential tumorgenicity have received more attention as big concerns for CRISPR-Cas therapeutics advancing toward the clinic.

We believe it is timely to summarize and analyze the emerging immunological risk and potential tumorgenicity with the CRISPR-Cas systems, to predict how this exciting genome editing market will affect other related segments of the entire life science market in the next few years. We also hope our opinion could serve as a ""crowd crystal"" on those discussions in response to the issues, and bring a better market environment for the technology to be sharpened and advanced into clinical applications.

The Report Includes:

    --  Detailed understanding of the two major types of adaptive immunity to
        Cas9 proteins, i.e. humoral immunity and cell-mediated immunity
    --  Comparison of in vivo and ex vivo CRISPR-Cas9 therapy and discussion
        about clinical safety and probability to enter human clinical trials
    --  Coverage of technical areas such as protein engineering and metagenomic
        analysis as driving forces to new CRISPR-Cas system discovery
    --  A look into the oncogenic risks by CRISPR-Cas9 genome editing and
        studies on the development and implementation of genetic systems
        designed to toggle tumor suppressor genes off and back-on again

Key Topics Covered:

Chapter 1 CRISPR Cas Genome Editing: Therapeutic or Thwarted by Preexisting Human Immunity?

    --  Immunogenicity Risk
    --  Potential Solutions to Overcome Preexisting Immunity to Cas Proteins in
        Humans
    --  Oncogenicity Risk
    --  Potential Solutions to Overcome Oncogenicity Risk
    --  What Could Happen Next?
    --  Scientific Community
    --  Investors
    --  Regulatory Societies
    --  What to Expect in the Market?

Chapter 2 A Note from the Editor

Chapter 3 Analyst's Credentials

For more information about this report visit https://www.researchandmarkets.com/research/q7pndb/switching_to?w=5

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SOURCE Research and Markets