Global Next-Generation Sequencing Market: Focus on Products and Services, Applications, Technology, 18 Countries Data, Industry Insights, and Competitive Landscape - Analysis and Forecast, 2019-2024
NEW YORK, April 15, 2019 /PRNewswire/ --
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The next-generation sequencing (NGS) industry is a multibillion market which consists of multitudinous companies involved in the manufacturing of instruments and kits and consumables and the development of software to bolster the NGS workflow. NGS has fundamentally changed the genomic research. It enables the scientist to sequence an entire genome, exome, or transcriptome by conducting experiments that were previously impossible. There were some limitations with traditional sequencing platforms. Platforms rely on the reads that are short and are less than 1Kb, further requiring scale up to millions of fragments that are sequenced in parallel.
Advancements in sequencing chemistry, molecular biology, and technical engineering over the years have profoundly increased the sequencing efficiency while decreasing the cost. Impressive progress in these fields have paved the way for the development of massively parallel, high-throughput sequencing technology, known as Next-Generation Sequencing (NGS).
The purpose of this study is to gain a holistic view of the NGS market in terms of various influencing factors, such as trends, technological advancements, role of service providers, and funding scenario in the market.The scope of this report constitutes of an in-depth study of the global next-generation sequencing market, including a thorough analysis of the products across different regions.
The market has been segmented into 'technology', 'product', 'application' and 'geographical regions'.The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions.
The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.
This research report aims at answering various aspects of the global NGS market with the help of key factors driving the market, restraints, and challenges that can possibly inhibit the overall market growth and the current growth opportunities that are likely to shape the future trajectory of the market expansion.The report includes an in-depth examination of the key ecosystem players and key strategies and developments taking place in this market.
In addition, the report includes market dynamics (market drivers, opportunities, and challenges) and industry analysis.
The research study considers the market share analysis for a comprehensive understanding of the global NGS market and assesses the factors governing the same. Funding scenarios, Porter's Five Force analysis, opportunity matrix, detailed product mapping, pricing analysis, value chain analysis, supply chain of NGS kits and consumables, growth share analysis by products and sequencing instrument provider, and R&D analysis have been included in the report.
The market by region has been further sub-segmented into countries, and the key market trends, key players, and recent developments have been listed in each sub-segment. The answers to the following key questions can be derived from this report:
-- What are the major market drivers, challenges, and opportunities in the global NGS market?
-- How did the NGS market evolve and what is its scope in the future?
-- What was the market share of the leading segments and sub-segments of the global NGS market in 2018?
-- How is each segment of the global NGS market expected to grow during the forecast period, and how much revenue is expected to be generated by each of the segments by the end of 2024?
-- What are the influencing factors that may affect the market share of the key players?
-- What is the influential stake held by the sequencing technology providers in the global NGS market?
-- What is the growth potential of different sequencing technologies in the forecast period 2019-2024?
-- What is expected to be the impact of commercialization of the portable sequencers on global healthcare industry?
-- What are the required features for an instrument to make $100 per genome sequencing a reality?
-- What is industry's best value chain practice?
-- Which are the leading raw material providers to the players offering NGS kits and consumables?
-- What is the market dominance by key players in each region?
-- How is the industry expected to evolve during the forecast period 2019- 2024?
-- What are the key developmental strategies which are being implemented by the key players to stand out in this market?
-- Which are the key service providers of the NGS market?
-- What is the funding scenario for the emerging companies that are investing substantial amount into the development of propitious technologies or products for bringing forth the evolution of the NGS market?
-- How has the market been segmented on the basis of sequencing technology? Which NGS technology is being adopted extensively for undertaking the sequencing procedure?
-- What is the market share of the companies by different segments, namely products, technology, applications, and geography, along with the global share analysis of the market?
The key players which have been contributing significantly to the NGS market include 10x Genomics, Agilent Technologies, Inc., bioMerieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.
Executive Summary
In the past few years, genome of several species has been sequenced using the automated sanger sequencing.There have been limitations associated with the sanger sequencing, leading to the development of improved sequencing technologies that are capable of sequencing a large number of human genome and are also capable of addressing the problems that were initially hindering growth of the next-generation sequencing (NGS) market.
Further, several research centres initiated the designing of the new sequencing technologies which would not require gels and would allow sequencing of a large number of samples in parallel. The three parallel technologies that were introduced in the early 21st century are Polonator, the Heliscope Single Molecule Sequencer Technology, and the Ion Semi-Conductor (Torrent Ion Sequencing). Since the introduction of these technologies, several attempts were made in the past to generate efficient sequencing technologies that would rely on single molecules, excluding the need for amplification steps. The two promising such technologies are Pacific Single molecule real time (SMRT) DNA sequencing and nanopore DNA sequencing. The advent of aforementioned technologies has unleased some novel methods which hold the potential to make the $100 genome dream a reality in the near future. These high-throughput sequencing methods have introduced new fields in the industry, which include analysis of RNA transcript, personal genomics, ChiP-Seq (Chromatin Immunoprecipitation sequencing), and ChiP-chip (Chromatin Immunoprecipitation coupled to DNA microarray), among others.
NGS in the clinical setting requires infrastructure, such as storage and computer capacity, and also the personnel expertise required to comprehensively analyse and interpret the subsequent data.
In addition, the volume of the data needs to be managed skilfully to properly extract the clinically important functions in a robust and clear interface.
The purpose of the study is to gain a holistic view of the next-generation sequencing market in terms of various influencing factors, such as recent trends, technological advancements, and regulatory aspects of the market.The scope of this report is centred upon conducting a detailed study of the technologies allied with the next-generation sequencing market.
The global next-generation sequencing market is segmented on the basis of four sections, namely product, technology, application and geography.The global market value was estimated using these four different approaches and was validated with one another.
These segments are further segmented into several sub-segments to ease the market estimation and to gain an in-depth view of the market.
The global next-generation sequencing market was $4.93 billion in 2018 and is estimated to grow over $9.91 billion by 2024. The global next-generation sequencing market is expected to grow with a double-digit compound annual growth rate between the years 2019 and 2024. With substantial increase in the demand for genome mapping programs and diagnostics tests based on sequencing, the NGS market is expected to witness an impressive growth and promises to be a lucrative field for investment. In terms of products, the kits and consumables sub-segment dominated the global next-generation sequencing market in 2018. However, the software sub-segment is expected to witness the highest CAGR in the forecast period from 2019 to 2024.
The reversible terminator sequencing technology currently dominates the global NGS market. Nanopore technology is estimated to witness the highest CAGR in the forecast period.
And by application, presently, the pharmaceuticals field holds the largest share of the global next-generation sequencing market and is expected to grow at 13.22% CAGR in the forecast period from 2019 to 2024. However, with the growing demand for non-invasive diagnostic procedures, the diagnostic field is expected to witness an impressive CAGR in the forecast period from 2019 to 2024. The global next-generation sequencing market is segmented by geographical regions into North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World (RoW). North America is the leading contributor to the global next-generation sequencing market and contributed to 48% of the global market values in 2018. However, Asia-Pacific is expected to grow at a CAGR of 17.25% in the forecast period 2019-2024. Moreover, the Asia Pacific market contributed approximately 18.95% of the total global market value in 2018.
A paradigm shift in the dynamics market is expected in 2023 with the introduction of portable technologies in full scale.The leading players in the market are taking necessary steps to tackle the shift in the dynamics and sustain in the competition.
The global next-generation sequencing market is majorly dominated by the U.S. players. Companies belonging to the U.S., such as Illumina, Inc., and Thermo Fisher Scientific, contributed to more than 70% of the market value in 2018. The key players which have significant contributions to the NGS market are 10x Genomics, Agilent Technologies, Inc., bioMérieux SA, Bio-Rad Laboratories, Inc., Danaher Corporation, F. Hoffmann-La Roche AG, GenapSys, Inc., Illumina, Inc., New England Biolabs, Inc., NuGEN Technologies Inc., Oxford Nanopore Technologies Limited, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN, and Thermo Fisher Scientific, among others.
The field of service providers for sequencing tests and the applications based on genome sequencing are perceived to be a lucrative business across the globe.With the impressive rise in the demand for sequencing-based diagnostics applications, namely non-invasive prenatal testing, companion diagnostics, and liquid biopsy, the service providing companies have gained popularity and acceptance across the globe.
Additionally, substantial investments are being made in bioinformatics startups and service providing companies.With the growing demand for genome mapping programs, a large pool of genomic data is being generated, and the key players of the market are seeking help from the bioinformatics startups to meet the market requirement.
Service providing companies help in expanding the global reach of the key players of the market and also play a significant role in increasing the adoptability of sequencing technologies across the globe.
Some of the opportunities on which significant work is being carried out presently in the market are hybridization of technologies and development of portable technologies.The best sequencer is the one with the ability to sequence long reeds, in short run time and with great accuracy.
The present available sequencers on the market possess any one of the mentioned features, but not all three.In spite of the substantial investments made by prominent companies to develop the instruments with the aforementioned features, it is not expected to be the reality at any time soon.
Thus, the hybridization of available technologies, such as SMRT and reversible semiconductor sequencing technology, is acknowledged to be a promising approach to cater to the needs of the market.
Countries Covered
-- North America
-- The U.S.
-- Canada
-- Europe
-- Germany
-- The U.K.
-- France
-- Italy
-- Spain
-- The Netherlands
-- Sweden
-- Denmark
-- Rest-of-Europe
-- Asia-Pacific
-- China
-- Japan
-- Australia
-- India
-- South Korea
-- Singapore
-- Rest-of-the-Asia-Pacific
-- Latin America
-- Brazil
-- Mexico
-- Rest-of-Latin America
-- Rest-of-the-World
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