Bened Biomedical Co., Ltd.: Psychobiotic PS128(TM) found to be a potential solution for Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD)

TAIPEI, Taiwan, May 22, 2019 /PRNewswire/ -- The possible correlation between autism spectrum disorder (ASD) and gut microbiota has long been explored. A recent study, published in?Nutrients?, shows that a specific probiotic supplementation composed of Lactobacillus plantarum PS128 (Psychobiotic PS128(TM), commercialized by Bened Biomedical Co., Ltd.) may significantly alleviate symptoms of Autism spectrum disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD).

The study titled "Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial" was conducted by Prof. Ying-Chieh Tsai of National Yang-Ming University and the ASD experts in Taiwan. It is the first study utilizing probiotics over a double-blind, randomized, parallel-group, placebo-controlled clinical trial for behavioral improvement in subjects with ASD, which sets a milestone in research on the relationship between autism and probiotics.

In this 4-week intervention study, a total of 80 boys with ASD aged 7-15 were included and randomized to receive either PS128 (30 billion CFU/capsule) or placebo with daily doses of 2 capsules. The results showed that PS128 significantly ameliorated opposition and defiance behaviors. In addition, the total score of the questionnaires for ADHD and oppositional defiant disorder, SNAP-IV, for younger children (aged 7-12) improved significantly compared with the placebo group.

Autism spectrum disorder (ASD) is a developmental disorder that affects communication and social behaviors. According to the WHO, it is estimated that 1 in 160 children worldwide suffer from ASD, with the US more than doubling that ratio at 1 in 59 children instead. While ASD has been so prevalent, there have been no effective cures to date; early intervention has been the main treatment for children with developmental disorders. Recent animal studies have also found that specific probiotic strain can regulate brain hormones and improve symptoms of autism.

According to Prof. Ying-Chieh Tsai, two further clinical studies investigating the effects of Psychobiotic PS128(TM) on children with ASD are also underway. In Taiwan, "Psychophysiological effects of Lactobacillus plantarum PS128 in preschool children with autism spectrum disorder: a randomized, placebo-controlled trial" including preschool children with ASD was conducted in a teaching hospital in Taipei. And "The effects of probiotics and oxytocin nasal spray on social behaviors of ASD children- a pilot study" was an international collaborative study with the Massachusetts General Hospital.

Besides the successful ASD and ADHD studies, there have been several other clinical studies underway for PS128 targeting Central Nervous System (CNS) disorders such as Parkinson's disease, depression, anxiety, Tourette syndrome, etc.

     Reference: "Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum
      Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial." Nutrients,
      2019 Apr 11;11(4),

ABOUT Psychobiotic PS128(TM)

Psychobiotic PS128(TM), the winner of "Probiotic Product of the Year" for the 2018 NutraIngredients-Asia Awards, is a novel psychobiotic that can modulate microbiota-gut-brain axis. As proven in the lab research and scientific publications, daily consumption of PS128(TM) can increase the concentration of dopamine and serotonin in key brain areas such as the prefrontal cortex or hippocampus. PS128(TM) is proven effective in preventing, alleviating and treating mental and movement disorders including autism, depression, anxiety, insomnia, IBS, Parkinson's disease, etc. The first PS128(TM) product was commercialized in 2015 by Bened Biomedical Co., Ltd. and is now available as a dietary supplement in more than 15 countries in the world.

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SOURCE Bened Biomedical Co., Ltd.