Global Gene Therapy Market Growth, Company Profiles, Clinical trials and Forecasts to 2022 - ReportsnReports

PUNE, India, Dec. 6, 2019 /PRNewswire/ -- The global gene therapy market is forecast to hit $363 million by 2022. Strengthened by recent approvals of Kymriah, Yescarta and Luxturna in the US, and a committed European, Japanese and Chinese environment, gene therapy is set to become a significant player in the bio-pharmaceutical industry. The space covers many therapeutic areas specifically, oncology, rare diseases, Parkinson's, HIV, severe combined immuno-deficiencies (SCID) and hemophilia. Gene Therapy Market is driven by over 2,200 clinical trials globally, with over 55% of this occurring in the US, followed by Europe, Canada and China. Recently, in November 2017, the FDA indicated that gene therapies will now qualify for a fast approval process, which will bring more therapies to market faster. However, the space also has significant challenges, such as manufacturing logistics, reimbursement and its high cost. This 310 page market analysis cutting-edge report tackles this growing but challenging industry, it highlights its strengths, weaknesses and opportunities and provides a comprehensive account of major companies, clinical trials and technological advancement.

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Since the FDA approved Kymriah (tisagenlecleucel), Yescarta (Axicabtagene ciloleucel) and Luxturna (voretigene neparvovec-rzyl) in 2017, the US gene therapy space has expanded significantly, underlined by the fact that over 55% of completed and ongoing trials are located in this geographic. Growth in the gene therapy industry has resulted in new commercial initiatives and the emergence of new startups and spin-off biotechs. Furthermore, gene therapy specifically has raised well over $600 million of venture capital in the last five years. Early stage companies have raised seed, Series A and Series B investment steadily since the market took off, including Spark Therapeutics, Avalanche Biotech, uniQure, Voyager Therapeutics, Editas Medicine and GenSight.

Gene therapy products approved between the years 2003 and 2017 include Gendicine, Oncorine, Rexin-G, Neovasculgen, Glybera, Imlygic, Strimvelis, Zalmoxis, Kymriah, Yescarta and Luxturna. Gendicine was approved for head and neck squamous cell carcinoma and has been in the Chinese market since 2003. Rexin-G was approved in the Philippines back in 2007 for the treatment of primary and metastatic cancer. Oncorine was approved in China in 2005 for nasopharyngeal carcinoma. The Russian market has Neovasculgen from 2011 for the treatment of peripheral arterial disease (PAD) and critical limb ischemia. The first gene therapy approved in E.U. was Glybera in 2012 for the treatment of familial lipoprotein lipase deficiency (LPL), however in October 2017 it was pulled from the market due to lack of patient demand. In 2015, Imlygic was approved in E.U. and also in the U.S. to treat melanoma, and Phase II results released in 2017 indicated its efficacy in combination with the checkpoint-inhibitor, Yervoy. In the E.U., Strimvelis was approved in 2016 for the treatment of adenosine deaminase severe combined immunodeficiency (ADA-SCID). In 2016, Zalmoxis was approved in E.U. for the treatment of leukemia. 2017 was a bumper year for gene therapy with Kymriah, Yescarta and Luxturna all gaining FDA approval.

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This report provides the reader with:

    --  Current Global Market Worth and Forecast with CAGR Through 2022
    --  Sub-Market Worth by Therapeutic Area (Cancer, Rare Diseases,
        Cardiovascular, Neurological, Ocular) and Forecast with CAGR Through
        2022
    --  Sub-Market Worth by Geography (Americas, Europe, RoW) and Forecast with
        CAGR Through 2022
    --  Sub-Market Worth by Technology (Gene Product, Service, Viral Vectors)
        and Forecast with CAGR Through 2022
    --  Insight into gene therapy technologies, challenges associated with
        developing therapeutic genes and disadvantages of gene therapy.
    --  Full outline of the gene therapy industry from the formative years
        through to products discovered during 1990 and 2017.
    --  Detailed descriptions of commercialized products approved between 2003
        and 2017 that include: Gendicine, Rexin-G, Oncorine, Neovasculgen,
        Glybera, Imlygic, Strimvelis, Zalmoxis, Kymriah, Yescarta and Luxturna.
    --  Description of seven of the Phase III product candidates that include:
        Generx, Collategene, LentiGlobin, Lenti-D, VM-202, Invosa and GS-010.
    --  Description of 21 Phase II product candidates that are set to have
        significant market share.
    --  Commercialization status of gene therapies in by geographic region
    --  Evaluation of gene therapy pricing
    --  Description of the first ever warranty offer by GSK for Strimvelis.
    --  A detailed analysis of various types of viruses used as vectors.
    --  Description of clinical applications of gene therapy and the various
        genetic and infectious diseases addressed by gene therapy.
    --  Description of 77 companies that are directly and indirectly associated
        with gene therapy industry.

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Key Questions Answered in this Report:

    --  What is the size of gene therapy market?
    --  What is the CAGR and market size over the next five years?
    --  What are the different sub-markets and their worth/CAGR over the next
        five years?
    --  What is gene augmentation therapy?
    --  What is suicide gene therapy?
    --  How is ex vivo gene delivery different from in vivo gene delivery?
    --  What are the types of gene therapies classified on the basis of targeted
        cell types?
    --  What is the role of CRISPR technology in gene therapy?
    --  What are the approved gene therapy products?
    --  How many gene therapy product candidates have reached the Phase III
        stage?
    --  How many Phase II gene therapy product candidates are there?
    --  What is the commercialization status of gene therapies in E.U. member
        countries?
    --  What are the prices of gene therapy products?
    --  What are the reasons for this extortionate pricing of gene therapies?
    --  Which company is offering warranty for its gene- therapy product?
    --  What is the current strength of gene therapy industry?
    --  Is it true that the real strength of gene therapy industry is based on
        the number of clinical trials?
    --  What is the total number of ongoing clinical trials as of 2017?
    --  What is the distribution of clinical trials by geography?
    --  Which countries are associated with gene therapy clinical trials?
    --  What are the major indications addressed by the clinical trials?
    --  Which genes are transferred in these clinical trials?
    --  How many Big Pharma are associated with the gene therapy industry?
    --  What are non-viral and viral vectors?
    --  What are the various features of viral vectors?
    --  Which viral vectors are predominantly used in gene therapy clinical
        trials?
    --  What are the major diseases addressed by therapeutic genes?
    --  Where is the gene therapy market heading, and what opportunities and
        challenges will it face?

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