Halozyme Reports Fourth Quarter 2020 Results And Full Year 2020 Results
SAN DIEGO, Feb. 23, 2021 /PRNewswire/ -- Halozyme Therapeutics, Inc. (NASDAQ: HALO) today reported financial results for the fourth quarter and full year ended December 31, 2020 and provided an update on its recent corporate activities and outlook.
"The fourth quarter capped an extraordinary year for Halozyme during which we transitioned to a profitable, high-growth company with strong prospects for continued growth over the long-term," said Dr. Helen Torley, president and chief executive officer. "Our strong growth prospects are fueled by recent product approvals for subcutaneous DARZALEX(®) (daratumumab) and Phesgo(®) (pertuzumab, trastuzumab and hyaluronidase) utilizing our ENHANZE(®) technology. Building on our portfolio of 5 commercialized partner products, we project the expansion of our development pipeline, including 4 products being evaluated in 7 phase 3 studies utilizing our ENHANZE(®) technology. We believe this advancing pipeline of products utilizing our ENHANZE(®) technology is setting the potential for multiple waves of future product launches that will deliver long-term growth in revenues, profitability and cash flow."
Fourth Quarter 2020 and Recent Highlights Include:
-- In February 2021, argenx announced a "go" decision for its ADHERE trial
evaluating subcutaneous (SC) efgartigimod with ENHANZE(®) technology in
chronic inflammatory demyelinating polyneuropathy (CIDP). argenx plans
to continue enrollment to include approximately 130 patients to support
potential registration of SC efgartigimod for the treatment of CIDP.
-- In January 2021, ENHANZE(®) partner Janssen Biotech, Inc. (Janssen)
received U.S. Food and Drug Administration (FDA) accelerated approval of
DARZALEX FASPRO(® )(daratumumab and hyaluronidase-fihj) in combination
with bortezomib, cyclophosphamide and dexamethasone (D-VCd) for the
treatment of adult patients with newly diagnosed light chain (AL)
amyloidosis. AL amyloidosis is a rare and potentially fatal disease that
develops when plasma cells in the bone marrow generate abnormal light
chains, which form amyloid deposits in vital organs and lead to organ
deterioration. There were previously no approved therapies for the
disease.
-- In January 2021, argenx initiated a Phase 3 study of ARGX-113 with
ENHANZE(®) technology in pemphigus vulgaris and pemphigus foliaceus,
rare autoimmune diseases that cause painful blisters on the skin and
mucous membranes.
-- In December 2020, argenx initiated a Phase 3 study of ARGX-113 with
ENHANZE(®) technology for patients with immune thrombocytopenia (ITP),
an immune disorder in which the blood does not clot normally, resulting
in a $15 million payment to Halozyme.
-- In December 2020, Roche initiated a Phase 3 study in patients with
non-small cell lung cancer for Tecentriq(®) (atezolizumab) with
ENHANZE(®) technology, resulting in a $17 million payment to Halozyme.
-- In December 2020, the Company announced that the European Commission
approved Roche's Phesgo(®), a fixed-dose combination of Perjeta(®
)(pertuzumab) and Herceptin(®) (trastuzumab) with ENHANZE(®)
technology, administered by SC injection for the treatment of patients
with early and metastatic HER2-positive breast cancer. This was the
first time the European Commission approved a product combining two
monoclonal antibodies that can be administered by a single SC injection
utilizing ENHANZE(®) technology.
-- In November 2020, the Company announced a global collaboration and
license agreement that provides Horizon Therapeutics plc exclusive
access to ENHANZE(®) technology for SC formulation of medicines
targeting IGF-1R for which the Company received an upfront payment of
$30 million. Horizon intends to use ENHANZE(®) technology to develop a
SC formulation of TEPEZZA(® )(teprotumumab-trbw), indicated for the
treatment of Thyroid Eye Disease, a serious, progressive and
vision-threatening rare autoimmune disease, potentially shortening drug
administration time, reducing healthcare practitioner time and offering
additional flexibility and convenience for patients.
-- In November 2020, Janssen initiated a Phase 1 study of amivantamab
utilizing ENHANZE(®) technology in advanced solid tumors.
-- In November 2020, the Company announced that Janssen submitted
regulatory applications to the FDA and European Medicines Agency (EMA)
seeking approval of DARZALEX FASPRO(®) in the U.S. and as DARZALEX(®)
SC in the European Union (EU) utilizing ENHANZE(®) technology in
combination with pomalidomide and dexamethasone (D-Pd) for the treatment
of patients with relapsed or refractory multiple myeloma who have
received at least one prior line of therapy.
-- In November 2020, Janssen submitted a Type II variation application to
the EMA seeking European approval for DARZALEX(®) SC utilizing
ENHANZE(® )technology to be used in the treatment of patients with AL
amyloidosis.
-- In October 2020, the Company announced that argenx expanded its existing
global collaboration and license agreement that was signed in February
2019. Under the expansion, argenx gained the ability to exclusively
access Halozyme's ENHANZE(®) drug delivery technology for three
additional targets upon nomination for a total of up to six targets. To
date, argenx has nominated two targets including the human neonatal Fc
receptor FcRn, which is blocked by efgartigimod, and complement
component C2.
-- During the fourth quarter, the Company repurchased approximately 1.1
million shares of common stock for $37.6 million at an average price per
share of $34.36, bringing the total 2020 repurchases to $150.0 million
at an average price of $23.05.
Fourth Quarter and Full Year 2020 Financial Highlights
-- Revenue for the fourth quarter was $121.7 million compared to $53.7
million for the fourth quarter of 2019. The year-over-year increase was
primarily driven by a $30.0 million upfront payment from Horizon, a
$15.0 million sales milestone from Janssen, an increase in royalty
revenue following the strong DARZALEX FASPRO(®) launch during the
second quarter and an increase in product sales. Revenue for the
quarter included $32.0 million in royalties, an increase of 86% compared
to $17.2 million in the prior year period.Total revenues for the full
year were $267.6 million, compared with $196.0 million in 2019,
representing growth of 37% year over year.
-- Research and development expenses for the fourth quarter were $7.4
million, compared to $45.1 million for the fourth quarter of 2019. The
decrease in expenses was due to a decrease in clinical trial
activities-related costs as a result of the Company halting its oncology
drug development efforts beginning in November 2019 and one-time
restructuring charges of $17.2 million in the prior year related to the
shift in strategic focus to the Company's ENHANZE(®)
technology.Research and development expenses for the full year were
$34.2 million, compared with $140.8 million in 2019.
-- Selling, general and administrative expenses for the fourth quarter were
$10.4 million, compared to $23.9 million for the fourth quarter of 2019.
The decrease was due to lower compensation and commercial-related
expenses related to the corporate restructuring announced in November
2019 and a one-time restructuring charge of $11.2 million in the prior
year.Selling, general and administrative expenses for the full year were
$45.7 million, compared with $77.3 million in 2019.
-- Operating income for the fourth quarter was $77.6 million, compared to
an operating loss of $32.1 million in the fourth quarter of
2019.Operating income for the full year was $144.3 million, compared to
an operating loss of $67.6 million in 2019.
-- Net income for the fourth quarter was $73.2 million, or $0.50 per share,
compared to a net loss in the fourth quarter of 2019 of $34.4 million,
or loss of $0.24 per share.Net income for the full year was $129.1
million or $0.91 per share, compared to a net loss of $72.2 million or
loss of $0.50 per share in 2019.
-- Cash, cash equivalents and marketable securities were $368.0 million at
December 31, 2020, compared to $421.3 million at December 31, 2019.
-- During 2020, the Company repurchased 6.5 million shares of common stock
for $150 million at an average price of $23.05, bringing the total for
share repurchases since the announcement of the Company's three-year
share repurchase program to $350.0 million at an average price of
$19.88.
Financial Outlook for 2021
Based on the latest information from collaboration partners and planned expenditures for the year, the Company expects:
-- Revenues of $375 million to $395 million, representing year-over-year
growth of 40%-48%, with revenues from royalties projected to
approximately double versus 2020;
-- Operating Income of $215 million to $235 million, representing
year-over-year growth of 49%-63%;
-- Earnings per share on a GAAP basis of $1.40 to $1.55, representing
year-over-year growth of 54%-70%.
The Company plans to repurchase up to $125 million in common stock during 2021 as part of the $550 million three-year share repurchase plan authorized by Halozyme's board of directors in 2019. The amount and timing of shares to be repurchased in 2021 will be subject to a variety of factors including market conditions, other business considerations and applicable legal requirements.
Webcast and Conference Call
Halozyme will webcast its Quarterly Update Conference Call for the fourth quarter of 2020 today, Tuesday, February 23, 2021 at 4:30 p.m. ET/1:30 p.m. PT. Dr. Torley will lead the call, which will be webcast live through the "Investors" section of Halozyme's corporate website and a replay will be available following the close of the call. To register for this conference call, please use this link: http://www.directeventreg.com/registration/event/7096809. After registering, you will receive an email confirmation that includes dial in details and unique conference call codes for entry. Registration is open through the live call. However, to ensure you are connected for the full call, we suggest registering a day in advance or at minimum 10 minutes before the start of the call.
About Halozyme
Halozyme is a biopharmaceutical company bringing disruptive solutions to significantly improve patient experiences and outcomes for emerging and established therapies. Halozyme advises and supports its biopharmaceutical partners in key aspects of new drug development with the goal of improving patients' lives while helping its partners achieve global commercial success. As the innovators of the ENHANZE(®) technology, which can reduce hours-long treatments to a matter of minutes, Halozyme's commercially-validated solution has positively impacted more than 400,000 patient lives via five commercialized products across more than 100 global markets. Halozyme and its world-class partners are currently advancing multiple therapeutic programs intended to deliver innovative therapies, with the potential to improve the lives of patients around the globe. Halozyme's proprietary enzyme rHuPH20 forms the basis of the ENHANZE(®) technology and is used to facilitate the delivery of injected drugs and fluids, potentially reducing the treatment burden of other drugs to patients. Halozyme has licensed its ENHANZE(®) technology to leading pharmaceutical and biotechnology companies including Roche, Baxalta, Pfizer, Janssen, AbbVie, Lilly, Bristol-Myers Squibb, Alexion, argenx and Horizon Therapeutics. Halozyme derives revenues from these collaborations in the form of milestones and royalties as the Company's partners make progress developing and commercializing their products being developed with ENHANZE(®). Halozyme is headquartered in San Diego. For more information visit www.halozyme.com.
Safe Harbor Statement
In addition to historical information, the statements set forth in this press release include forward-looking statements including, without limitation, statements concerning the Company's expected future financial performance (including the Company's financial outlook for 2021) and expectations for future growth, profitability, revenue, operating income, cash flow, expenses and earnings-per-share and the Company's plans to continue its share repurchase program. Forward-looking statements regarding the Company's ENHANZE(®) drug delivery technology may include the possible activity, benefits and attributes of ENHANZE(®), the possible method of action of ENHANZE(®), its potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery of injectable medications through subcutaneous delivery. Forward-looking statements regarding the Company's ENHANZE(® )business may include potential growth driven by our partners' development and commercialization efforts, the size and growth prospects of our partners' drug franchises, potential new ENHANZE(® )collaborations and collaborative targets and regulatory review and potential approvals of new ENHANZE(® )products. These forward-looking statements are typically, but not always, identified through use of the words "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "possible," "should," "continue," and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors, including unexpected levels of revenues, expenditures and costs, inability to sustain profitability, unexpected delays in the execution of the Company's share repurchase program, unexpected results or delays in the growth of the Company's ENHANZE(®) business, or in the development, regulatory review or commercialization of ENHANZE(®) products, including any potential delays caused by the current COVID-19 global pandemic, regulatory approval requirements, unexpected adverse events or patient outcomes and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the Company's most recently filed Annual Report on Form 10-K filed with the Securities and Exchange Commission.
Contact:
Al Kildani
Vice President, Investor Relations and Corporate Communications
858-704-8122
ir@halozyme.com
Halozyme Therapeutics, Inc
Condensed Consolidated Statements of Operations
(Unaudited)
(In thousands, except per share amounts)
Three Months Ended Twelve Months Ended
December 31,
December 31,
2020 2019 2020 2019
---
Revenues:
Royalties $
31,997 $
17,230 $
88,596 $
69,899
Product sales, net 32,455 22,693 55,987 66,048
Revenues under collaborative
agreements 57,251 13,742 123,011 60,045
Total revenues 121,703 53,665 267,594 195,992
Operating expenses:
Cost of product sales 26,272 16,687 43,367 45,546
Research and development 7,380 45,111 34,236 140,804
Selling, general and
administrative 10,427 23,929 45,736 77,252
Total operating expenses 44,079 85,727 123,339 263,602
Operating income (loss) 77,624 (32,062) 144,255 (67,610)
Other income (expense):
Investment and other income,
net 661 1,333 5,425 6,986
Interest expense (5,036) (3,731) (20,378) (11,627)
Net income (loss) before income
taxes 73,249 (34,460) 129,302 (72,251)
Income tax expense 85 (63) 217 (11)
Net income (loss) $
73,164 $
(34,397) $
129,085 $
(72,240)
Net income (loss) per share:
Basic $
0.54 $
(0.24) $
0.95 $
(0.50)
Diluted $
0.50 $
(0.24) $
0.91 $
(0.50)
Shares used in computing net income (loss) per
share:
Basic 135,107 141,046 136,206 144,329
Diluted 145,122 141,046 141,463 144,329
Halozyme Therapeutics, Inc
Condensed Consolidated Balance Sheets
(Unaudited)
(In thousands)
December 31, December 31,
2020 2019
---
ASSETS
Current assets:
Cash and cash equivalents $
147,703 $
120,179
Marketable securities,
available-for-sale 220,310 301,083
Accounts receivable, net and
other contract assets 97,730 59,442
Inventories 60,747 29,359
Prepaid expenses and other
assets 28,274 33,373
Total current assets 554,764 543,436
Property and equipment, net 10,593 10,855
Prepaid expenses and other
assets 14,067 11,083
Restricted cash 500 500
Total assets $
579,924 $
565,874
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable $
1,928 $
6,434
Accrued expenses 20,483 55,649
Deferred revenue, current
portion 1,746 4,012
Current portion of long-term
debt, net 397,228 19,542
Total current liabilities 421,385 85,637
Deferred revenue, net of current
portion 4,026 1,247
Long-term debt, net - 383,045
Other long-term liabilities 3,466 4,180
Stockholders' equity:
Common stock 135 137
Additional paid-in capital 625,483 695,066
Accumulated other comprehensive
income (loss) 22 240
Accumulated deficit (474,593) (603,678)
Total stockholders' equity 151,047 91,765
Total liabilities and
stockholders' equity $
579,924 $
565,874
View original content to download multimedia:http://www.prnewswire.com/news-releases/halozyme-reports-fourth-quarter-2020-results-and-full-year-2020-results-301233889.html
SOURCE Halozyme Therapeutics, Inc.
