Allergan to Present Data from its Anti-Infectives Portfolio at ASM Microbe 2017 in New Orleans

DUBLIN, May 31, 2017 /PRNewswire/ -- Allergan plc (NYSE: AGN) today announced new data from its anti-fectives portfolio will be featured in 16 presentations at the upcoming American Society for Microbiology (ASM) Microbe, June 1-5, 2017, in New Orleans.

Eight of the presentations will feature information about AVYCAZ(® )(ceftazidime and avibactam), including data exploring the activity of AVYCAZ in resistant Gram-negative bacteria as well as results from the International Network for Optimal Resistance Monitoring (INFORM) program, one of the largest ongoing pathogen surveillance programs in the United States.

Six presentations will focus on the in vitro activity of TEFLARO(®) (ceftaroline fosamil) against a variety of Gram-positive pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA), with remaining presentations to focus on MONUROL(®) (fosfomycin tromethamine) and ATM-AVI (an investigational, fixed-dose antibiotic combining aztreonam and avibactam), respectively.

"Allergan is at the forefront in the fight against resistant pathogens and difficult-to-treat-infections, and we remain focused on pathogen surveillance and antibiotic susceptibility research," said David Nicholson, Ph.D., Chief Research & Development Officer, Allergan. "Producing critical data that characterizes regional resistance patterns and disease prevalence helps inform the treatment decisions of physicians, and ultimately, the care of patients."

The scheduled times and titles of the presentations are as follows:

AVYCAZ (ceftazidime and avibactam)

Friday, June 2, 12:45 p.m. - 2:45 p.m. CT (Central Time)

    --  Activity of ceftazidime-avibactam (CAZ-AVI) against Enterobacteriaceae
        isolated from different infection types as part of the INFORM global
        surveillance program, 2015
    --  Activity of ceftazidime-avibactam (CAZ-AVI) against Pseudomonas
        aeruginosa isolated from different infection types as part of the INFORM
        global surveillance program, 2015
    --  A locally tested surveillance study to evaluate the current activity of
        ceftazidime-avibactam (C/A) against Gram-negative pathogens collected in
        the United States in 2015-2016 as part of the INFORM study
    --  Activity of ceftazidime-avibactam and comparator agents tested against
        isolates harboring  -lactamase genes detected using whole genome
        sequencing analysis

Saturday, June 3, 12:15 p.m. - 2:15 p.m. CT (Central Time)

    --  Synergistic activity of ceftazidime-avibactam (CAZ-AVI) and fosfomycin
        (FOS) against extended-spectrum- -lactamase-(ESBL) and
        carbapenemase-producing Gram-negative (GN) bacteria
    --  Colistin-resistant Enterobacteriaceae in the US: Not all is lost

Sunday, June 4, 12:15 p.m. - 2:15 p.m. CT (Central Time)

    --  The impact of acute kidney injury (AKI) on the risk of mortality and
        healthcare utilization among patients treated with polymyxins for severe
        Gram-negative infections
    --  Intrinsic resistance mechanisms detected among ceftazidime-avibactam
        susceptible and resistant Pseudomonas aeruginosa (PSA) isolates
        collected from United States (US) hospitals (2015)

TEFLARO (ceftaroline fosamil)

Friday, June 2, 12:45 p.m. - 2:45 p.m. CT (Central Time)

    --  Ceftaroline fosamil for the treatment of pneumonia caused by
        methicillin-resistant Staphylococcus aureus: CAPTURE study experience
    --  Ceftaroline fosamil use for skin infections or community-acquired
        pneumonia with bacteremia

Sunday, June 4, 12:15 p.m. - 2:15 p.m. CT (Central Time)

    --  2014-2015 global assessment of the in vitro activities of ceftaroline
        and comparative agents against bacterial pathogens frequently causing
        community-acquired respiratory tract infections
    --  Comparative in vitro activities of ceftaroline and ceftriaxone against
        clinical isolates of Staphylococcus aureus and coagulase-negative
        Staphylococci from 37 countries during 2014-2015
    --  Antimicrobial susceptibility trends among Staphylococcus aureus from US
        hospitals: results from 7 years of the ceftaroline (AWARE) surveillance
        program (2009-2015)
    --  Ceftaroline activity against Gram-positive isolates from elderly
        patients hospitalized with pneumonia in the intensive care unit (ICU):
        results from the AWARE surveillance program, 2008-2015

Monurol (fosfomycin tromethamine)

Saturday, June 3, 12:15 p.m. - 2:15 p.m. CT (Central Time)

    --  A Locally Tested Surveillance Study to Evaluate the Current Activity of
        Fosfomycin (FOS) against Enterobacteriaceae Associated with Urinary
        Tract Infections Collected in the United States in 2015- 2016

ATM-AVI (aztreonam and avibactam)

Friday, June 2, 12:45 p.m. - 2:45 p.m. CT (Central Time)

    --  In vitro activity of aztreonam-avibactam (ATM-AVI) against
        drug-resistant and metallo- -lactamase-producing Enterobacteriaceae
        isolated as part of a global surveillance program, 2012-2015

Full abstracts can be found on the ASM Microbe website at https://www.asm.org/index.php/asm-microbe-2017.

About AVYCAZ(®)
AVYCAZ was first approved in the U.S. in February 2015 for the treatment of adult patients with complicated intra-abdominal infections (cIAI), in combination with metronidazole, and cUTI, including pyelonephritis, caused by designated susceptible pathogens, including certain Enterobacteriaceae and Pseudomonas aeruginosa. In June 2016, the FDA approved the addition of Phase 3 clinical data to the label supporting the use of AVYCAZ, in combination with metronidazole, in cIAI patients, including subsets of patients with infections caused by CAZ-NS pathogens and pathogens producing certain ESBLs. In January 2017, the FDA approved the addition of Phase 3 clinical data (two studies) to the label supporting the use of AVYCAZ in patients with cUTI, including pyelonephritis, including subsets of patients with infections caused by CAZ-NS pathogens.. In one of these studies, AVYCAZ demonstrated higher combined clinical and microbiological cure rates vs. Best Available Therapy (BAT) in patients with cUTI due to CAZ-NS pathogens; similar results were seen in a subset of patients with infections caused by pathogens producing certain ESBL groups, including select KPC (Klebsiella pneumoniae carbapenemase), and AmpC beta-lactamases.

AVYCAZ has demonstrated in vitro activity against Enterobacteriaceae in the presence of some beta-lactamases and ESBLs of the following groups: TEM, SHV, CTX-M, Klebsiella pneumoniae carbapenemase (KPCs), AmpC and certain oxacillinases (OXA). AVYCAZ also demonstrated in vitro activity against Pseudomonas aeruginosa in the presence of some AmpC beta-lactamases, and certain strains lacking outer membrane porin (OprD). AVYCAZ is not active against bacteria that produce metallo-beta lactamases and may not have activity against Gram-negative bacteria that overexpress efflux pumps or have porin mutations.

Ceftazidime and avibactam is being jointly developed with Pfizer. Allergan holds the rights to commercialize ceftazidime and avibactam in North America under the brand name AVYCAZ, while Pfizer holds the rights to commercialize the combination in the rest of the world under the brand name Zavicefta.

INDICATIONS AND USAGE

Complicated Intra-Abdominal Infections (cIAI)
AVYCAZ® (ceftazidime and avibactam), in combination with metronidazole, is indicated for the treatment of complicated intra-abdominal infections (cIAI) caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Klebsiella oxytoca, Citrobacter freundii complex, and Pseudomonas aeruginosa in patients 18 years or older.

Complicated Urinary Tract Infections (cUTI), including Pyelonephritis
AVYCAZ is indicated for the treatment of complicated urinary tract infections (cUTI) including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii complex, Proteus mirabilis, and Pseudomonas aeruginosa in patients 18 years or older.

Usage
To reduce the development of drug-resistant bacteria and maintain the effectiveness of AVYCAZ and other antibacterial drugs, AVYCAZ should be used to treat only indicated infections that are proven or strongly suspected to be caused by susceptible bacteria.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS
AVYCAZ is contraindicated in patients with known serious hypersensitivity to the components of AVYCAZ (ceftazidime and avibactam), avibactam?containing products, or other members of the cephalosporin class.

WARNINGS AND PRECAUTIONS

    --  In a Phase 3 cIAI trial, clinical cure rates were lower in a subgroup of
        patients with baseline creatinine clearance (CrCl) of 30 to less than or
        equal to 50 mL/min compared to those with CrCl greater than 50 mL/min.
        The reduction in clinical cure rates was more marked in patients treated
        with AVYCAZ plus metronidazole compared to meropenem-treated patients.
        Clinical cure rates in patients with normal renal function/mild renal
        impairment (CrCl greater than 50 mL/min) was 85% (322/379) with AVYCAZ
        plus metronidazole vs 86% (321/373) with meropenem, and clinical cure
        rates in patients with moderate renal impairment (CrCl 30 to less than
        or equal to 50 mL/min) was 45% (14/31) with AVYCAZ plus metronidazole vs
        74% (26/35) with meropenem. Within this subgroup, patients treated with
        AVYCAZ received a 33% lower daily dose than is currently recommended for
        patients with CrCl of 30 to less than or equal to 50 mL/min. The
        decreased clinical response was not observed for patients with moderate
        renal impairment at baseline (CrCl of 30 to less than or equal to 50
        mL/min) in the Phase 3 cUTI trials. Monitor CrCl at least daily in
        patients with changing renal function and adjust the dosage of AVYCAZ
        accordingly.
    --  Serious and occasionally fatal hypersensitivity (anaphylactic) reactions
        and serious skin reactions have been reported in patients receiving
        beta-lactam antibacterial drugs. Before therapy with AVYCAZ is
        instituted, careful inquiry about previous hypersensitivity reactions to
        other cephalosporins, penicillins, or carbapenems should be made.
        Exercise caution if this product is to be given to a penicillin or other
        beta-lactam-allergic patient because cross sensitivity among beta-lactam
        antibacterial drugs has been established. Discontinue the drug if an
        allergic reaction to AVYCAZ occurs.
    --  Clostridium difficile-associated diarrhea (CDAD) has been reported for
        nearly all systemic antibacterial drugs, including AVYCAZ, and may range
        in severity from mild diarrhea to fatal colitis. Careful medical history
        is necessary because CDAD has been reported to occur more than 2 months
        after the administration of antibacterial drugs. If CDAD is suspected or
        confirmed, antibacterials not directed against C. difficile should be
        discontinued, if possible.
    --  Seizures, nonconvulsive status epilepticus (NCSE), encephalopathy, coma,
        asterixis, neuromuscular excitability, and myoclonia have been reported
        in patients treated with ceftazidime, particularly in the setting of
        renal impairment. Adjust dosing based on creatinine clearance.
    --  Prescribing AVYCAZ in the absence of a proven or strongly suspected
        bacterial infection is unlikely to provide benefit to the patient and
        increases the risk of the development of drug-resistant bacteria.

ADVERSE REACTIONS

    --  The most common adverse reactions in cIAI patients (>=5% when used with
        metronidazole) were diarrhea (8%), nausea (7%), and vomiting (5%). The
        most common adverse reactions in cUTI patients (3%) were diarrhea and
        nausea.

Please see full Prescribing Information for AVYCAZ at www.avycaz.com.

ABOUT TEFLARO(®)

TEFLARO was first approved by the U.S. FDA in October 2010 for the treatment of adults with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI) due to designated susceptible pathogens. TEFLARO is a bactericidal cephalosporin with activity against both Gram-positive and Gram-negative pathogens. TEFLARO is indicated in adult and pediatric patients 2 months of age and older for the treatment of CABP, including cases caused by Streptococcus pneumoniae, and ABSSSI, including cases caused by methicillin-resistant Staphylococcus aureus (MRSA). TEFLARO is the first and only cephalosporin with activity against MRSA in ABSSSI that is approved in the U.S.. In clinical trials, TEFLARO was generally well-tolerated with an adverse event profile consistent with the cephalosporin class of antibiotics. TEFLARO has been administered in over 2.3 million days of therapy, treating more than 350,000 patients.

Allergan plc (formerly Forest Laboratories) obtained the worldwide rights (excluding Japan, where Takeda Pharmaceuticals holds rights) to TEFLARO in 2007 when it acquired Cerexa, Inc., a privately held biopharmaceutical company. In August 2009, Forest Laboratories and AstraZeneca (NYSE: AZN) entered into a definitive collaboration agreement to co-develop and commercialize ceftaroline fosamil in all markets outside the U.S., Canada and Japan.

INDICATIONS AND USAGE

    --  TEFLARO(®) (ceftaroline fosamil) is indicated in adult and pediatric
        patients 2 months of age and older for the treatment of acute bacterial
        skin and skin structure infections (ABSSSI) caused by susceptible
        isolates of the following Gram-positive and Gram-negative
        microorganisms: Staphylococcus aureus (including methicillin-susceptible
        and -resistant isolates), Streptococcus pyogenes, Streptococcus
        agalactiae, Escherichia coli, Klebsiella pneumoniae, and Klebsiella
        oxytoca.
    --  TEFLARO is also indicated in adult and pediatric patients 2 months of
        age and older for the treatment of community-acquired bacterial
        pneumonia (CABP) caused by susceptible isolates of the following
        Gram-positive and Gram-negative microorganisms: Streptococcus pneumoniae
        (including cases with concurrent bacteremia), Staphylococcus aureus
        (methicillin-susceptible isolates only), Haemophilus influenzae,
        Klebsiella pneumoniae, Klebsiella oxytoca, and Escherichia coli.

    --  To reduce the development of drug-resistant bacteria and maintain the
        effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should
        be used to treat only ABSSSI or CABP that are proven or strongly
        suspected to be caused by susceptible bacteria. Appropriate specimens
        for microbiological examination should be obtained in order to isolate
        and identify the causative pathogens and to determine their
        susceptibility to ceftaroline. When culture and susceptibility
        information are available, they should be considered in selecting or
        modifying antibacterial therapy. In the absence of such data, local
        epidemiology and susceptibility patterns may contribute to the empiric
        selection of therapy.

IMPORTANT SAFETY INFORMATION

Contraindications

    --  TEFLARO is contraindicated in patients with known serious
        hypersensitivity to ceftaroline or other members of the cephalosporin
        class. Anaphylaxis has been reported with ceftaroline.

Warnings and Precautions

Hypersensitivity Reactions

    --  Serious and occasionally fatal hypersensitivity (anaphylactic) reactions
        and serious skin reactions have been reported with beta-lactam
        antibacterial drugs. Before therapy with TEFLARO is instituted, careful
        inquiry about previous hypersensitivity reactions to other
        cephalosporins, penicillins, or carbapenems should be made. Maintain
        clinical supervision if this product is to be given to a penicillin- or
        other beta-lactam-allergic patient, because cross sensitivity among
        beta-lactam antibacterial agents has been clearly established.
    --  If an allergic reaction to TEFLARO occurs, discontinue TEFLARO and
        institute appropriate treatment and supportive measures.

Clostridium difficile-Associated Diarrhea

    --  Clostridium difficile-Associated Diarrhea (CDAD) has been reported for
        nearly all systemic antibacterial agents, including TEFLARO, and may
        range in severity from mild diarrhea to fatal colitis. Careful medical
        history is necessary because CDAD has been reported to occur more than 2
        months after the administration of antibacterial agents. If CDAD is
        suspected or confirmed, antibacterials not directed against C. difficile
        should be discontinued, if possible.

Direct Coombs' Test Seroconversion

    --  In adults, seroconversion from a negative to a positive direct Coombs'
        test result occurred in 120/1114 (10.8%) of patients receiving TEFLARO
        and 49/1116 (4.4%) of patients receiving comparator drugs in the four
        pooled adult Phase 3 trials.
    --  In children, seroconversion from a negative to a positive direct Coombs'
        test result occurred in 42/234 (17.9%) of patients receiving TEFLARO and
        3/93 (3.2%) of patients receiving comparator drugs in the three pooled
        pediatric trials.
    --  No adverse reactions representing hemolytic anemia were reported in any
        treatment group. If anemia develops during or after treatment with
        TEFLARO, drug-induced hemolytic anemia should be considered. If
        drug-induced hemolytic anemia is suspected, discontinuation of TEFLARO
        should be considered and supportive care should be administered to the
        patient if clinically indicated.

Development of Drug-Resistant Bacteria

    --  Prescribing TEFLARO in the absence of a proven or strongly suspected
        bacterial infection is unlikely to provide benefit to the patient and
        increases the risk of the development of drug-resistant bacteria.

Adverse Reactions in Adults

    --  In the four pooled adult Phase 3 clinical trials, serious adverse
        reactions occurred in 98/1300 (7.5%) of patients receiving TEFLARO and
        100/1297 (7.7%) of patients receiving comparator drugs. Treatment
        discontinuation due to adverse reactions occurred in 35/1300 (2.7%) of
        patients receiving TEFLARO and 48/1297 (3.7%) of patients receiving
        comparator drugs with the most common adverse reactions leading to
        discontinuation being hypersensitivity for both treatment groups at a
        rate of 0.3% in the TEFLARO group and 0.5% in the comparator group.
    --  The most common adverse reactions occurring in >2% of patients receiving
        TEFLARO in the adult pooled Phase 3 clinical trials were diarrhea (5%)
        nausea (4%), and rash (3%).

Adverse Reactions in Pediatrics

    --  In the three pooled pediatric clinical trials, serious adverse reactions
        occurred in 10/257 (4%) of patients receiving TEFLARO and 3/102 (3%) of
        patients receiving comparator drugs. Treatment discontinuation due to
        adverse reactions occurred in 10/257 (3.9%) of patients receiving
        TEFLARO and 2/102 (2%) of patients receiving comparator drugs with the
        most common adverse reaction leading to discontinuation being rash in
        2/257 (0.8%) of patients treated with TEFLARO.
    --  The most common adverse reactions occurring in >= 3% of patients
        receiving TEFLARO in the pooled pediatric clinical trials were diarrhea
        (8%), rash (7%), vomiting (5%), pyrexia (3%) and nausea (3%).

Drug Interactions

    --  No clinical drug-drug interaction studies have been conducted with
        TEFLARO. There is minimal potential for drug- drug interactions between
        TEFLARO and CYP450substrates, inhibitors, or inducers; drugs known to
        undergo active renal secretion; and drugs that may alter renal blood
        flow.

Use in Specific Populations

    --  There have been no adequate and well-controlled studies with TEFLARO in
        pregnant or nursing women.
    --  Safety and effectiveness in pediatric patients below the age of 2 months
        have not been established as no data are available.
    --  Because elderly patients, those >=65 years of age, are more likely to
        have decreased renal function and ceftaroline is excreted primarily by
        the kidney, care should be taken in dose selection in this age group and
        it may be useful to monitor renal function. Dosage adjustment for
        elderly patients should therefore be based on renal function.
    --  Dosage adjustment is required in adult patients with moderate (CrCl >30
        to <=50 mL/min) or severe (CrCl >=15 to <=30mL/min) renal impairment and
        in patients with end-stage renal disease (CrCl <15 mL/min).  There is
        insufficient information to recommend a dosage regimen for pediatric
        patients with CrCl < 50 ml/min/1.73m(2).
    --  The pharmacokinetics of ceftaroline in patients with hepatic impairment
        have not been established.

Please also see the full Prescribing Information at www.TEFLARO.com.

ABOUT MONUROL

MONUROL (fosfomycin tromethamine) was first approved by the U.S. FDA in 1997 for the treatment of women with uncomplicated urinary tract infections (uUTI) due to designated susceptible pathogens. MONUROL is a broad spectrum antibiotic and is the only one day, single dose treatment for uUTI's in women. With 18 years of experience it has a well studied clinical efficacy and safety profile. MONUROL is recommended by the Infectious Disease Society of America (IDSA) as a treatment option for uUTI and maintains good in-vitro activity against itsindicated pathogens.

Allergan plc holds the commercial rights to MONUROL in the U.S., and Zambon maintains the rights in the rest of the world.

INDICATIONS AND USAGE FOR MONUROL

    --  MONUROL (fosfomycin tromethamine) is indicated only for the treatment of
        uncomplicated urinary tract infections (acute cystitis) in women due to
        susceptible strains of Escherichia coli and Enterococcus faecalis.
    --  MONUROL is not indicated for the treatment of pyelonephritis or
        perinephric abscess. If persistence or reappearance of bacteriuria
        occurs after treatment with MONUROL, other therapeutic agents should be
        selected.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

    --  MONUROL is contraindicated in patients with known hypersensitivity to
        the drug.

WARNINGS

    --  Clostridium difficile-associated diarrhea (CDAD) has been reported with
        use of nearly all antibacterial agents, including MONUROL, and may range
        in severity from mild diarrhea to fatal colitis. Careful medical history
        is necessary since CDAD has been reported to occur over two months after
        the administration of antibacterial agents. If CDAD is suspected or
        confirmed, ongoing antibiotic use not directed against C. difficile may
        need to be discontinued.

PRECAUTIONS

    --  Do not use more than one single dose of MONUROL to treat a single
        episode of acute cystitis. Repeated daily doses of MONUROL did not
        improve the clinical success or microbiological eradication rates
        compared to single dose therapy, but did increase the incidence of
        adverse events. Patients should be informed that if their symptoms do
        not improve in 2 to 3 days, they should contact their healthcare
        provider.
    --  When coadministered with MONUROL, metoclopramide lowers the serum
        concentration and urinary excretion of fosfomycin. Other drugs that
        increase gastrointestinal motility may produce similar effects.
    --  There are no adequate and well-controlled studies of MONUROL in pregnant
        women. Therefore, MONUROL should be used in pregnancy only if clearly
        needed.
    --  It is not known whether fosfomycin tromethamine is excreted in human
        milk. Because many drugs are excreted in human milk and because of the
        potential for serious adverse reactions in nursing infants from MONUROL,
        a decision should be made whether to discontinue nursing or to not
        administer the drug, taking into account the importance of the drug to
        the mother.
    --  Safety and effectiveness in children age 12 years and under have not
        been established in adequate and well-controlled studies.

ADVERSE REACTIONS

    --  In clinical trials, the most frequently reported adverse events
        occurring in >1% of the MONUROL-treated patients (n=1233) were: diarrhea
        (9.0%), vaginitis (5.5%), nausea (4.1%), headache (3.9%), dizziness
        (1.3%), asthenia (1.1%), and dyspepsia (1.1%).

Please also see the full Prescribing Information at www.MONUROL.com

About Allergan plc
Allergan plc (NYSE: AGN), headquartered in Dublin, Ireland, is a bold, global pharmaceutical company and a leader in a new industry model - Growth Pharma. Allergan is focused on developing, manufacturing and commercializing branded pharmaceutical, device, biologic, surgical and regenerative medicine products for patients around the world.

Allergan markets a portfolio of leading brands and best-in-class products for the central nervous system, eye care, medical aesthetics and dermatology, gastroenterology, women's health, urology and anti-infective therapeutic categories.

Allergan is an industry leader in Open Science, a model of research and development, which defines our approach to identifying and developing game-changing ideas and innovation for better patient care. With this approach, Allergan has built one of the broadest development pipelines in the pharmaceutical industry with 70+ mid-to-late stage pipeline programs currently in development.

Allergan's success is powered by our more than 18,000 global colleagues' commitment to being Bold for Life. Together, we build bridges, power ideas, act fast and drive results for our customers and patients around the world by always doing what is right.

With commercial operations in approximately 100 countries, Allergan is committed to working with physicians, healthcare providers and patients to deliver innovative and meaningful treatments that help people around the world live longer, healthier lives every day.

For more information, visit Allergan's website at www.Allergan.com.

Forward-Looking Statement
Statements contained in this press release that refer to future events or other non-historical facts are forward-looking statements that reflect Allergan's current perspective on existing trends and information as of the date of this release. Actual results may differ materially from Allergan's current expectations depending upon a number of factors affecting Allergan's business. These factors include, among others, the difficulty of predicting the timing or outcome of FDA approvals or actions, if any; the impact of competitive products and pricing; market acceptance of and continued demand for Allergan's products; difficulties or delays in manufacturing; and other risks and uncertainties detailed in Allergan's periodic public filings with the Securities and Exchange Commission, including but not limited to Allergan's Annual Report on Form 10-K for the year ended December 31, 2016 and Allergan's Quarterly Report on Form 10-Q for the period ended March 31, 2017. Except as expressly required by law, Allergan disclaims any intent or obligation to update these forward-looking statements.

CONTACTS:

Allergan:

Investors:
Daphne Karydas
(862) 261-8006

Media:
Mark Marmur
(862) 261-7558

Tara Schuh
(201) 427-8888

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