The Launch of First-in-Class Biologic Therapies Will Drive Significant Growth Within the Osteoarthritic Pain Market Through 2026

BURLINGTON, Mass., Sept. 7. 2017 /PRNewswire/ -- Decision Resources Group finds that the launch of novel biologic therapies targeting nerve growth factor (NGF) will be the main driver of growth in the osteoarthritic pain market following these agents' launch, beginning in 2020, across the major pharmaceutical markets (United States, France, Germany, Italy, Spain, United Kingdom, Japan). Given the widely generic current market and the anticipated high price of these agents, their use will be reserved for later line in a small percentage of patients who are not surgical candidates or who prefer to delay surgery. Nevertheless, the sizeable osteoarthritic pain population and expected high prices of the anti-NGF therapies will drive overall major-market sales of nearly $23.5 billion in 2026.

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Other key findings from the Disease Landscape and Forecast report entitled Osteoarthritic Pain:

    --  Anti-NGF therapies from Pfizer/Eli Lilly and Regeneron/Teva/Mitsubishi
        Tanabe Pharma will account for nearly three-quarters of major-market
        osteoarthritic pain sales in 2026. Current market-leading classes of
        opioid analgesics and NSAIDs will maintain the majority of patient share
        and consistent sales through 2026.
    --  Sales within the opioid analgesics class continue to be driven by
        branded abuse-deterrent formulations (ADFs), reflecting efforts to curb
        prescription opioid abuse. However, the cost, perceived effectiveness,
        and continued risk of dependence with these agents limit future growth
        opportunities. Gr?nenthal/Depomed's cebranopadol, with its anticipated
        lower abuse risk, will propel sales of the class after its launch in
        2022.
    --  NSAIDs remain the most prescribed agents for osteoarthritic pain due to
        the variety and extensive generic availability in this class. Side
        effects associated with chronic use are a lingering concern for
        prescribers, and while nonoral formulations seek to resolve these
        concerns, development in this class has diminished from market
        saturation. Sales of the NSAIDs class will remain constant through 2022
        before decreasing.
    --  The prevalence of osteoarthritic pain will continue to increase through
        2026 due to an aging population and rising obesity rates.

Comments from Decision Resources Group Analyst Joyce Spadafora, ALM:

    --  "We expect the anti-NGF monoclonal antibodies will be the most
        commercially successful novel drug class for the treatment of
        osteoarthritic pain. While safety risks continue to shadow their
        perception among interviewed physicians, large ongoing Phase III safety
        trials may ameliorate lingering concerns. Their impressive efficacy
        demonstrated to date and anticipated premium pricing, together with the
        current absence of totally effective and safe analgesics and the large
        osteoarthritic pain patient population, will yield blockbuster
        major-market sales by 2026."
    --  "Opioid analgesics will remain a key player in the treatment of
        osteoarthritic pain. Despite increasing safety and abuse concerns
        associated with this class, the presence of ADFs of long-acting opioid
        analgesics in the United States and the anticipated improved safety
        profile of cebranopadol will prevent erosion of class sales over the
        forecast period."

Additional Resources:

    --  Joyce Spadafora has written a blog on the subject, which can be found
        here: http://bit.ly/2gphILN

About Decision Resources Group
DRG, a subsidiary of Piramal Enterprises Ltd., is the premier source for global healthcare data and market intelligence. A trusted partner for over 20 years, DRG helps companies competing in the global healthcare industry make informed business decisions. Organizations committed to the developing and delivering life-changing therapies to patients rely on DRG's in-house team of expert healthcare analysts, data scientists, and consultants for critical guidance. DRG products and services, built on extensive data assets and delivered by experts, empower organizations to succeed in complex healthcare markets.

Media contact:

Decision Resources Group
Stephanie Cooper
scooper@teamdrg.com

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SOURCE Decision Resources Group