Decision Resources Group Projects G7 Sales Of The Multiple Sclerosis Market To Exceed $25 Billion In The Next Decade

BURLINGTON, Mass., Nov. 7, 2017 /PRNewswire/ -- Decision Resources Group (DRG) finds that ex-manufacturer sales for multiple sclerosis (MS) disease-modifying therapies (DMTs) will grow 2% annually from an estimated $21 billion in 2016 to greater than $25 billion in 2026 in the major pharmaceutical markets (United States, France, Germany, Italy, Spain, United Kingdom, and Japan). DRG projects that recent market entrants and an additional six new brands will earn more than $9 billion in combined sales at the end of the forecast period, led by Roche/Genentech's anti-CD20 monoclonal antibody (MAb) Ocrevus. Expanding DMT choice and the launch of additional generic alternatives will further complicate the MS treatment algorithm, expand the drug-treated patient population, and continue to drive market fragmentation.

Other key findings from DRG's Multiple Sclerosis: Disease Landscape & Forecast report:

    --  Driven by the launch of Ocrevus, DRG estimates 6% annual growth of the
        G7 drug-treated population in primary-progressive MS (PP-MS), a new
        segmentation in our model. Ocrevus and the launch of Novartis's novel
        S1P receptor modulator siponimod, which demonstrated efficacy in SP-MS
        patients, will support lesser yet notable growth in the drug-treated
        secondary-progressive MS (SP-MS) population.
    --  Anti-CD20 MAbs (from Roche/Genentech, Novartis/Genmab, TG Therapeutics)
        and novel oral brands (from Novartis, Celgene/Receptos, Actelion,
        Alkermes, and Merck Serono) will further intensify competition in
        relapsing forms of MS, garnering combined major-market patient share of
        approximately 20% in the relapsing-remitting MS segment by the end of
        our study period.
    --  We forecast a continued decline in use of platform injectables (IFN- s,
        Copaxone, and glatiramer acetate generics), reaching approximately
        one-third total patient share in 2026, while oral DMTs (Tecfidera,
        Gilenya, Aubagio, new brands, and generics) garner more than 40% share
        by that time. The looming entry of generic oral DMTs and additional
        generic formulations of glatiramer acetate, important disruptors in this
        high-cost market, will add to a complex dynamic among early-line
        mainstays.

Comments from Decision Resources Group Analyst Sarah Soucy:

    --  "In line with data from our ongoing U.S. launch-tracking series, we
        expect robust uptake of Ocrevus in the underserved PP-MS population,
        with spillover use in nonrelapsing SP-MS. In relapsing forms of MS, we
        foresee mostly switch use, but anti-CD20s MAbs stoke the perennial
        debate among interviewed experts about early intervention with
        high-efficacy drugs--a treatment pattern that could proliferate with
        time, safety willing."
    --  "Thanks to new agents' diverse clinical profiles and a heterogeneous
        disease, we expect all DMTs to establish a clinical role--some bigger
        than others--as neurologists strive to individualize treatment for their
        MS patients. However, we may be approaching the limit of efficacy that
        is achievable by immune-targeted drugs. Considerable need remains for
        therapies that halt or reverse disease progression through
        neuroprotective, remyelinating, or reparative mechanisms, truly the next
        frontier for clinical development in MS. Biogen's opicinumab, now under
        investigation in a new Phase II trial, could be a pioneering medication
        in this critical area."

For more information on purchasing this report, please visit our website.

About Decision Resources Group
DRG, a subsidiary of Piramal Enterprises Ltd., is the premier source for global healthcare data and market intelligence. A trusted partner for over 20 years, DRG helps companies competing in the global healthcare industry make informed business decisions. Organizations committed to the developing and delivering life-changing therapies to patients rely on DRG's in-house team of expert healthcare analysts, data scientists, and consultants for critical guidance. DRG products and services, built on extensive data assets and delivered by experts, empower organizations to succeed in complex healthcare markets.

Media contact:

Decision Resources Group
Stephanie Cooper
(212) 414-7570
scooper@dresources.com

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SOURCE Decision Resources Group