TCR2 Therapeutics Presents Preclinical Data on its Lead Solid Tumor and Blood Cancer Programs at the American Association for Cancer Research (AACR) Annual Meeting
CAMBRIDGE, Mass., March 28, 2019 /PRNewswire/ -- TCR(2) Therapeutics Inc. (Nasdaq: TCRR), a clinical-stage immunotherapy company developing the next generation of novel T cell receptor (TCR) therapies for patients suffering from cancer, today announced that preclinical data on its lead solid tumor program TC-210 and its lead blood cancer program TC-110 will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2019. The AACR Annual Meeting 2019 will be held March 29 to April 3, 2019 at the Georgia World Congress Center, Atlanta, GA.
Abstracts are available on the AACR conference website at http://www.aacr.org. Information contained in the abstracts was at the time of submission on February 1, 2019.
Title: Preclinical evaluation of TC-210, a mesothelin-specific T cell receptor (TCR) fusion construct (TRuC(TM)) T cells for the treatment of solid tumors. (Abstract #2307) https://www.abstractsonline.com/pp8/#!/6812/presentation/2608
Presenter/Authors: Jian Ding(1), Holly Horton(1), Seema Shah(1), Adam Zieba(1), Janani Krishnamurthy(1), Thomas Ashhurst(2), Ashley V. Menk(3), Patrick A. Baeuerle(1), Nicholas J. C. King(2), Gregory Delgoffe(3), Robert Hofmeister(1), Daniel R. Getts(1).( 1)TCR(2) Therapeutics Inc. Cambridge, MA, (2)University of Sydney, Sydney, Australia, (3)University of Pittsburgh, Pittsburgh, PA
Session: PO.IM02.03 Adoptive Cell Therapy 2, Section 22
Session date and time: Monday, April 1, 2019 1:00 PM - 5:00 PM ET
-- The company's lead program targeting mesothelin-positive solid tumors,
TC-210 has shown robust anti-tumor activity in cellular assays and
animal models of lung, ovarian, and malignant plural mesothelioma
cancers. In these studies, TC-210 was compared head-to-head against
mesothelin-targeting chimeric antigen receptor (CAR)-T cells (MSLN CAR-T
cells) bearing the same mesothelin binder expressed on TC-210.
-- Results showed mesothelin-dependent T cell activation, expansion, and
tumor clearance by TC-210 was faster than that observed with MSLN CAR-T
cells. Additionally, unlike MSLN-CAR-T cells, TC-210 showed increased
levels of oxidative phosphorylation and mitochondrial respiratory
reserve, attributes associated with long-term memory T cells. Finally,
robust tumor clearance by TC-210 was achieved at systemic cytokine
levels that were significantly lower than those observed in MSLN CAR-T
cell treated animals.
-- Together, these findings warrant the investigation of TC-210 in clinical
trials as effective treatment for mesothelin-expressing tumors with
potentially lower rates of adverse events.
Title: Preclinical evaluation of TC-110: CD19-specific T cell receptor (TCR) fusion construct (TRuC(TM)) T cell for the treatment of hematologic malignancies. (Abstract #2330) https://www.abstractsonline.com/pp8/#!/6812/presentation/2631
Presenter/Authors: Holly Horton(1), Jian Ding(1), Seema Shah(1), Jessica Gierut(1), Niko Thorausch(2), Anna Morath(2), Wolfgang Schamel(2), Marcela Maus(3), Patrick A. Baeuerle(1), Robert Hofmeister(1), Daniel R. Getts(1). (1)TCR(2) Therapeutics Inc. Cambridge, MA, (2)University of Freiburg, Freiburg, Germany, (3)Massachusetts General Hospital, Boston, MA
Session: PO.IM02.03 Adoptive Cell Therapy 2, Section 22
Session date and time: Monday, April 1, 2019 1:00 PM - 5:00 PM ET
-- TC-110 is a CD19-specific -TRuC(TM) variant. Results of this
preclinical evaluation of TC-110 showed:
-- In vitro, TC-110 T cells are equally potent as CAR T cells in
eliminating tumor cells, while producing less inflammatory
cytokines.
-- In preclinical mouse models of acute lymphoblastic leukemia and
Burkitt's lymphoma, TC-110 T cells demonstrate better efficacy than
second generation CAR-T cells bearing CD28 or 41BB co-stimulatory
domains. Of note, the efficacy of TC-110 T cells, both in vitro and
in vivo, does not require added co-stimulatory signals.
-- These findings demonstrate the efficacy of TC-110 T cells both in vitro
and in preclinical mouse models, indicating the clinical potential of
TRuC(TM) platform for treating hematologic malignancy.
About TCR(2 )Therapeutics
TCR(2) Therapeutics Inc. is a clinical-stage immunotherapy company developing the next generation of novel T cell therapies for patients suffering from cancer. TCR(2)'s( )proprietary T cell receptor (TCR) Fusion Construct T cells (TRuC(TM)-T cells) specifically recognize and kill cancer cells by harnessing the entire TCR signaling complex independent of human leukocyte antigen (HLA). In preclinical studies, TRuC-T cells have demonstrated superior anti-tumor activity compared to chimeric antigen receptor T cells (CAR-T cells), while exhibiting lower levels of cytokine release. The Company's lead TRuC-T cell product candidate, TC-210, is currently being studied in a Phase 1/2 clinical trial to treat patients with mesothelin-positive non-small cell lung cancer (NSCLC), ovarian cancer, malignant pleural/peritoneal mesothelioma, and cholangiocarincoma. For more information about TCR(2), please visit www.tcr2.com.
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SOURCE TCR2 Therapeutics
