Global Immune Checkpoint Modulators Market 2020 - Current and Emerging Key Products & Players, Main Unmet Needs, R&D Challenges, Strategies & Opportunities, Clinical Development Trends

DUBLIN, April 24, 2020 /PRNewswire/ -- The "Immuno-oncology: Focus on Developments and Opportunities in Immune Checkpoint Modulators" report has been added to ResearchAndMarkets.com's offering.

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    --  What are the main types of immune checkpoint modulators?
    --  What are the key marketed products and agents in development in the 8MM?
    --  What are the key checkpoint targets and indications that are being
        investigated?
    --  What are the main unmet needs in immune checkpoint inhibitors (ICIs)?
    --  What are the main R&D challenges and strategies in ICIs?
    --  What development trends exist or are anticipated in ICI-based therapies?
    --  What are the opportunities in biomarker development and microbiome
        studies?

This report focuses on immune checkpoint modulators and provides an overview of the current and emerging key products and players within the 8MM (France, Germany, Italy, Spain, UK, US, Japan, China), main unmet needs; R&D challenges, strategies and opportunities; and clinical development trends.

The report also includes competitive analysis of marketed products and a tabular analysis of key checkpoint targets and indications investigated in clinical trials. In addition, the report also provides an overview and critical assessment of the future landscape including bispecific antibodies, predictive/prognostic biomarkers and microbiome.

Key Highlights

    --  Although ICIs work in some tumors such as lung cancer and melanoma, the
        majority of cancers fail to respond to ICIs, mainly due to various
        tumor- and immune-related factors.
    --  These tumor types are refractory, benefitting the least from available
        therapies. Remission rates in all tumors are high, which can result in
        secondary resistance to ICIs.
    --  The understanding of endogenous resistance mechanisms is poor and ICI
        monotherapy has not been able to overcome issues related to secondary
        resistance.
    --  None of the current biomarkers used in development and in clinical
        practice are sensitive or accurate enough.
    --  Without robust predictive/prognostic biomarkers, it is difficult to
        execute effective patient segmentation in clinical trials, match the
        best drugs for combination therapies, or predict and proactively manage
        side effects that might arise due to a treatment.
    --  Lack of robust, predictive biomarkers creates a bottleneck for companies
        to develop safer and effective therapies for both small subsets of
        patients as well as for common tumors.
    --  Current research in novel checkpoint targets provides possible rationale
        for addressing primary and secondary resistance in some tumor types.
    --  In addition to immunotherapy combinations, companies are investigating
        targeted therapies as possible additions to ICI-based combinations to
        increase response rates in tumors with known mutations and genetic
        aberrations.
    --  In the future, with emerging pharmacological and immune biomarkers, the
        publisher expects numerous doublet and triplet combination therapies to
        appear in all lines of treatment.

Report Scope

    --  Quotes from 10 US-, 5EU-, and Japan-based key opinion leaders
    --  Robust analysis of high-prescriber survey conducted with 94 oncologists
    --  Summary of main types of immune checkpoint modulators
    --  Competitive Analysis of key marketed/pipeline products in 8MM
    --  Overview and critical analysis of main unmet needs, R&D challenges and
        strategies.
    --  Overview and analysis of development opportunities in current and
        emerging clinical targets, and novel combinations across key
        indications.
    --  Overview of biomarker technologies and microbiome
    --  Call-outs of key information and details
    --  Insight from specialist oncology analysts

The report will enable you to:

    --  Develop business strategies by understanding the trends shaping and
        driving ICI-based therapies in the 8MM.
    --  Drive revenues by understanding the key trends, innovative combination
        strategies and indications likely to impact the utility of immune
        checkpoint modulators in the future.
    --  Design your development strategy through a review of potential novel
        targets or combinations across indications.
    --  Understand the challenges and strategies impacting the development of
        immune checkpoint modulators in preclinical studies and clinical trials.
    --  Organize your sales and marketing efforts by understanding ICI-based
        combination approaches across indications that present maximum
        opportunities for consolidations, investments, and strategic
        partnerships.
    --  Develop strategies by understanding expert perceptions of unmet needs in
        key indications in oncology, and the potential for immune checkpoint
        modulators to meet those needs.

Key Topics Covered

1. Preface
1.1 Related Reports
1.2 Upcoming Reports
1.3 Abbreviations

2. Executive Summary
2.1 Key Findings from the publisher's Research and Analysis of the ICI Field
2.2 KOL Insights: Unmet Needs and Opportunities Across Indications
2.3 KOL Insights: Biomarker Strategies and Microbiome

3. Immuno-oncology Definition and Overview
3.1 Introduction: Essentials of Immuno-oncology
3.2 IO: Different than Other Pillars of Cancer Treatment
3.3 IO Milestones Timeline for Immunotherapies: Rapid Breakthrough Achieved Following the Introduction of Immune Checkpoint Inhibitors
3.4 Immune Checkpoints as Evasion Mechanisms for Cancer: Main Types of Immune Checkpoint Targets
3.5 Cancer Immunogenicity and More: Factors that Influence Resposne to ICI Therapies
3.6 TMB and T Cell Infiltration: Scale of Immunogenicity for Tumors
3.7 Types of Immune Contexture: A Narrow Therapeutic Window for ICIs

4. Immune Checkpoint Inhibitors: Key Players and Product Profiles, Approvals, and Approved Indications Summary
4.1 Key Players and Market Shares by Geography (8MM)
4.2 Key Marketed Product Profiles
4.3 Approvals Summary for ICIs in the 7MM
4.4 Approvals Summary for ICIs in China
4.5 Approved Indications Summary for ICIs (8MM)

5. Competitive Assessment of Marketed ICIs: Route to Market Success for ICIs in Development
5.1 Historical and Forecast Sales for Immune Checkpoint Inhibitors (Global)
5.2 SWOT Analysis for Marketed ICIs in the 8MM
5.3 Key Development and Approval Information for ICIs (First Indications Approved in the US)
5.4 Clinical and Commercial Factors that Contribute to the Success of ICIs
5.5 Objectives and Strategies to Increase the Impact of ICIs in Cancer Treatment

6. New Immune Checkpoint Modulators in Clinical Trials

7. Major Unmet Needs in Immune Checkpoint Inhibitors

8. R&D Strategies: Challenges and Opportunities

9. New Checkpoint Modulators: Pipeline Analysis and Key Pipeline Product Profiles

10. Future Lanscape in Immuno-oncology: Bispecific Agents, Novel Biomarkers, and Microbiome

Companies Mentioned

    --  Agenus
    --  AkesoBio
    --  AstraZeneca
    --  Beigene
    --  Bristol-Myers Squibb
    --  F. Hoffmann-La Roche
    --  GlaxoSmithKline
    --  Innate Pharma
    --  Innovent
    --  Jiangsu Hengrui Medicine
    --  Jounce Therapeutics
    --  Merck & Co.
    --  Merck KGaA
    --  Novartis AG
    --  Pfizer
    --  Regeneron Pharmaceuticals
    --  Sanofi
    --  Shanghai Junshi Biotech

For more information about this report visit https://www.researchandmarkets.com/r/fijh8d

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