Insomnia Data 2020: US Leads in Global Insomnia Clinical Trials, Germany Leads Major European Markets and Japan Has Top Spot in Asia

DUBLIN, May 21, 2020 /PRNewswire/ -- The "Market Spotlight: Insomnia (2020)" report has been added to ResearchAndMarkets.com's offering.

http://mma.prnewswire.com/media/539438/Research_and_Markets_Logo.jpg

This Market Spotlight report covers the Insomnia market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways

    --  It is estimated that in 2017, there were 1.7 billion prevalent cases of
        insomnia worldwide, and forecasts that number to increase to 1.9 billion
        prevalent cases by 2026.
    --  It is estimated that Asia had the largest number of prevalent cases in
        2017 (675.7 million cases). The approved drugs in the insomnia space
        target GABA-A receptor, hypocretin/orexin receptor, chloride channel 2,
        chloride, melatonin receptor, histamine H1 receptor, and potassium
        channels. The majority of marketed drugs are administered via the oral
        route, with the remainder being available in sublingual, oral
        transmucosal, or intravenous formulations.
    --  The largest proportion of industry-sponsored drugs in active clinical
        development for insomnia are in Phase III, with only one drug in the
        NDA/BLA phase.
    --  Therapies in mid-to-late-stage development for insomnia focus on targets
        such as melatonin receptor, hypocretin/orexin receptor, GABA-A receptor,
        GABA receptors, histamine H1 receptor, serotonin 5-HT1 receptor, and
        serotonin 5-HT2B receptor. All of the pipeline drugs for insomnia are
        administered via the oral route.
    --  High-impact upcoming events in the insomnia space comprise an expected
        approval decision for ZolpiMist, topline Phase II and Phase III trial
        results for daridorexant, and an estimated patent expiration for
        Belsomra.
    --  The overall likelihood of approval of a Phase I insomnia asset is 18.1%,
        and the average probability a drug advances from Phase III is 66.7%.
        Drugs, on average, take 8.0 years from Phase I to approval, compared to
        9.8 years in the overall neurology space.
    --  There have been 19 licensing and asset acquisition deals involving
        insomnia drugs during 2015-20. The largest deal was the $150.8m
        agreement in August 2016 between Shionogi and Lupin's Japanese
        subsidiary, Kyowa, for the transfer of marketing rights of Shionogi's 21
        long-listed drugs to Kyowa.
    --  The distribution of clinical trials across Phase I-IV indicates that the
        majority of trials for insomnia have been in the early and mid-phases of
        development, with 59% of trials in Phase I-II, and 41% in Phase III-IV.
    --  The US has a substantial lead in the number of insomnia clinical trials
        globally. Germany leads the major European markets, while Japan has the
        top spot in Asia.
    --  Clinical trial activity in the insomnia space is dominated by completed
        trials. Takeda has the highest number of completed clinical trials for
        insomnia, with 65 trials.
    --  Takeda leads the industry sponsors with the highest overall number of
        clinical trials for insomnia, followed by Merck & Co.

Key Topics Covered:

OVERVIEW

KEY TAKEAWAYS

DISEASE BACKGROUND

    --  Insomnia Subtypes

TREATMENT

    --  Non-Medical Treatments
    --  Medical Treatments

EPIDEMIOLOGY

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION

    --  Hetlioz for Insomnia (August 16, 2019)
    --  Seltorexant for Insomnia (June 24, 2019)
    --  Dayvigo for Insomnia (October 17, 2018)

KEY UPCOMING EVENTS

KEY REGULATORY EVENTS

    --  Dayvigo Awaits Controlled Substance Scheduling
    --  FDA Issues Split Classification On Cranial Electrotherapy Stimulator
        Devices
    --  New Zealand Switches Melatonin From Prescription To OTC Status
    --  US FDA Converges With Other Regulators On Insomnia Drug Warnings, But
        Broader Safety Disagreements Persist
    --  German Melatonin Denial Is Further Blow' To PUMA Scheme

PROBABILITY OF SUCCESS

LICENSING AND ASSET ACQUISITION DEALS

    --  Eisai Buys Out Global Rights To Lemborexant

PARENT PATENTS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE

    --  Sponsors By Status
    --  Sponsors By Phase

BIBLIOGRAPHY

    --  Prescription Information

For more information about this report visit https://www.researchandmarkets.com/r/rspfxw

About ResearchAndMarkets.com
ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com

For E.S.T Office Hours Call +1-917-300-0470
For U.S./CAN Toll Free Call +1-800-526-8630
For GMT Office Hours Call +353-1-416-8900

U.S. Fax: 646-607-1907
Fax (outside U.S.): +353-1-481-1716

View original content:http://www.prnewswire.com/news-releases/insomnia-data-2020-us-leads-in-global-insomnia-clinical-trials-germany-leads-major-european-markets-and-japan-has-top-spot-in-asia-301063588.html

SOURCE Research and Markets