Innovent to Present Clinical Data of Multiple Novel Molecules at the 2024 ASCO Annual Meeting
SAN FRANCISCO and SUZHOU, China, April 24, 2024 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, announces that about 20 accepted abstracts of clinical data from multiple trials in relation to multiple novel mono-/bi-specific antibodies and antibody-drug-conjugates (ADCs) as well as innovative drugs including TYVYT® (sintilimab injection), olverembatinib, taletrectinib (ROS1 TKI) from its oncology pipeline will be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024 from May 31 to June 4, 2024, in Chicago, IL, U.S..
Dr. Hui Zhou, Senior Vice President of Innovent, stated: "We are very pleased to present a robust set of clinical data for our next-generation innovative bispecific antibodies and ADC molecules for the first time at the 2024 ASCO Annual Meeting. We observed the preliminary efficacy and safety signals for those innovative candidates, underscoring their potential for further development and clinical value. As one of the few biopharmaceutical companies with both the technology platforms and robust pipeline in "IO+ADC" areas, Innovent will continue to make breakthroughs in the field of cancer treatment, and is committed to providing doctors and patients with more innovative, effective and safe treatment options."
Details on the abstracts are listed below:
Abstract Title Abstract Session Type and Title Presentation
No. Time (CDT) Presenter
IBI363 (PD-1/IL-2 bispecific antibody)
First-in-class PD-1/IL-2 bispecific antibody fusion protein IBI363 in patients with advanced colorectal cancer: Safety and efficacy 3593
Poster Session 6/1/2024 Dr. Yiwen
results from a phase I study. Chen
-Gastrointestinal Cancer 1:30 PM
-Colorectal and Anal -4:30 PM
First-in-class PD-1/IL-2 bispecific antibody fusion protein IBI363 in patients with advanced melanoma: Safety and efficacy results
from a phase I study. 9562
Poster Session 6/1/2024 Dr. Yu Chen
-Melanoma/Skin Cancers 1:30 PM
-4:30 PM
First-in-class PD-1/IL-2 bispecific antibody fusion protein IBI363 in patients with other solid tumors: Safety and efficacy results
from a phase I study. e14593
Online publication 5/23/2024 Dr. Xueli Bai
5:00 PM
IBI389 (anti-CLDN18.2/CD3 bispecific antibody)
Safety and preliminary efficacy results of IBI389, an anti-CLDN18.2/CD3 bispecific antibody, in patients with solid tumors and gastric
or gastro-esophageal tumors: A phase 1 dose escalation and expansion study. 2519
Rapid Oral Abstract 6/2/2024 Dr. Li Zheng
-Developmental Therapeutics 11:30AM
-Immunotherapy -1:00 PM
Safety and efficacy of IBI389, an anti-CLDN18.2/CD3 bispecific antibody, in patients with advanced pancreatic ductal adenocarcinoma: Clinical Science Symposium
Preliminary results from a phase 1 study. ?
Oral
?
-Building Novel Antibody-Based
Approaches in Gastrointestinal
4011 Cancers 6/2/2024 Dr. Jihui Hao
4:30 PM
-6:00 PM
IBI343(anti-CLDN18.2 ADC)
Safety and efficacy of IBI343 (anti-claudin18.2 antibody-drug conjugate) in patients with advanced pancreatic ductal adenocarcinoma or 3037
Poster Session 6/1/2024 Dr. Xianjun
biliary tract cancer: Preliminary results from a phase 1 study. Yu
-Developmental Therapeutics 9:00 AM
-Molecularly Targeted Agents and
Tumor Biology -12:00 PM
IBI310 (anti-CTLA-4 antibody)
Neoadjuvant treatment of IBI310 (anti-CTLA-4 antibody) plus sintilimab (anti-PD-1 antibody) in patients with microsatellite 3505
Oral Abstract Session 6/2/2024 Dr. Rui-Hua
instability-high/mismatch repair-deficient colorectal cancer: Results from a randomized, open-labeled, phase Ib study. Xu
-Gastrointestinal Cancer 8:00 AM
-Colorectal and Anal -11:00 AM
Taletrectinib (ROS1 TKI)
Efficacy and safety of taletrectinib in patients with advanced or metastatic ROS1+ non-small cell lung cancer: The phase 2 TRUST-I
study. 8520
Rapid Oral Abstract 6/1/2024 Dr. Wei Li
-Lung Cancer 4:30PM
-Non-Small Cell Metastatic -6:00 PM
IBI110 (anti-LAG-3 antibody)
Efficacy and safety of IBI110 (anti-LAG-3 antibody) plus sintilimab (anti-PD-1 antibody) in patients with advanced alveolar soft 11559
Poster Session 6/1/2024 Dr. Jiayong
part sarcoma: Results from a phase II study. Liu
-Sarcoma 1:30 PM
-4:30 PM
TYVYT(R)(sintilimab)[1]
Efficacy and safety of sintilimab plus paclitaxel and cisplatin as neoadjuvant therapy for locally advanced cervical cancer: A phase II 5512
Rapid Oral Abstract 6/1/2024 Dr. Jihong
trial. Liu
-Gynecologic Cancer 8:00 AM
-9:30 AM
Neoadjuvant sintilimab and platinum-doublet chemotherapy followed by transoral robotic surgery for HPV-associated resectable 6011 Clinical Science Symposium (Oral) Dr. Ming Song
oropharyngeal cancer: single-arm, phase II trial. -making the Cut: Decision Support and Dr.
Tools in Surgically Treated HPV+ Shida Yan
Oropharyngeal Cancer 6/3/2024
3:00 PM
-4:00 PM
Sintilimab, doxorubicin and ifosfamide (AI) as first-line treatment in patients with advanced undifferentiated pleomorphic sarcoma 11505
Oral Abstract Session 6/3/2024 Dr. Zhiguo
(UPS), synovial sarcoma (SS), myxoid liposarcoma (MLPS) and dedifferentiated liposarcoma (DDLPS): A single-arm phase 2 trial. Luo
-Sarcoma 3:00 PM
-6:00 PM
Updated survival results of BBCAPX-II: sintilimab combined with bevacizumab and CapeOx as first-line treatment in patients with RAS-
mutant, microsatellite stable, unresectable metastatic colorectal cancer. 3563
Poster Session 6/1/2024 Dr. Ying Yuan
-Colorectal and Anal 1:30 PM
-4:30 PM
Updated results and biomarker analyses from the phase 2 trial of nab-paclitaxel plus sintilimab as second-line therapy for advanced or 4037
Poster Session 6/1/2024 Dr. Zhichao
metastatic gastric/gastroesophageal junction adenocarcinoma (G/GEJA). Jiang
-Gastrointestinal Cancer 1:30 PM
-Gastroesophageal, Pancreatic, and
Hepatobiliary -4:30 PM
Sintilimab plus axitinib for advanced fumarate hydratase-deficient renal cell carcinoma: A multi-center, open-label, single-arm,
phase II study (SAFH). 4523
Poster Session 6/2/2024 Dr. Hao Zeng
-Genitourinary Cancer 9:00 AM
-Kidney and Bladder -12:00 AM
Anlotinib combined with sintilimab as first-line treatment in patients with advanced non-clear cell renal cell carcinoma (nccRR):
Preliminary results from an exploratory prospective multicentre clinical study. 4544
Poster Session 6/2/2024 Dr. Pei Dong
-Genitourinary Cancer 9:00 AM
-Kidney and Bladder -12:00 AM
Fruquintinib plus sintilimab in treated advanced endometrial cancer (EMC) patients (pts) with PMMR status: Results from a multicenter, 5619
Poster Session 6/3/2024 Dr. Xiaohua
single-arm phase 2 study. Wu
-Gynecologic Cancer 9:00 AM
-12:00 AM
Final survival outcomes and exploratory biomarker analysis from the randomized, phase 2 neoSCORE trial: Two versus three cycles of
neoadjuvant sintilimab plus chemotherapy for resectable non-small cell lung cancer 8048
Poster Session 6/3/2024 Dr.Fuming Qiu
.
-Lung Cancer 1:30 PM
-Non-Small Cell Local -4:30 PM
-Regional/Small Cell/Other
Thoracic Cancers
Olverembatinib
Updated efficacy results of olverembatinib (HQP1351) in patients with tyrosine kinase inhibitor (TKI)-resistant succinate dehydrogenase
(SDH)-deficient gastrointestinal stromal tumor (GIST) and paraganglioma 11502
Oral Abstract Session 6/3/2024 Dr. Haibo Qiu
-Sarcoma 3:00 PM
-6:00 PM
About Innovent
Innovent is a leading biopharmaceutical company founded in 2011 with the mission to provide high-quality biologics that are affordable to all. The company discovers, develops, manufactures and commercializes innovative medicines that treat some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has 10 products in the market, 3 new drug applications under the NMPA review, 5 assets in Phase III or pivotal clinical trials and 18 more molecules in early clinical stage. Innovent partners with over 30 global healthcare leaders, including Eli Lilly, Roche, Sanofi, Adimab, Incyte and MD Anderson Cancer Center.
Guided by the motto, "Start with Integrity, Succeed through Action," Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.
Statement: Innovent does not recommend the use of any unapproved drug (s)/indication (s).
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[1]
Those abstracts of TYVYT(sintilimab) are from investigator-initiated clinical trials (IIT),except one abstract #5619.
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