Mantle Cell Lymphoma Clinical Trial Pipeline Insights Featuring 20+ Companies | DelveInsight
Mantle cell lymphoma is a rare and aggressive type of non-Hodgkin lymphoma originating from B-cells in the "mantle zone" of the lymph nodes. The development of novel targeted therapies and immunotherapies, such as Bruton's tyrosine kinase (BTK) inhibitors, is improving treatment outcomes and driving market growth for Mantle cell lymphoma.
LAS VEGAS, Sept. 19, 2024 /PRNewswire/ -- DelveInsight's 'Mantle Cell Lymphoma Pipeline Insight 2024' report provides comprehensive global coverage of pipeline mantle cell lymphoma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the mantle cell lymphoma pipeline domain.
https://mma.prnewswire.com/media/1082265/DelveInsight_Logo.jpg
Key Takeaways from the Mantle Cell Lymphoma Pipeline Report
-- DelveInsight's mantle cell lymphoma pipeline report depicts a robust
space with 20+ active players working to develop 22+ pipeline therapies
for mantle cell lymphoma treatment.
-- Key mantle cell lymphoma companies such as AbbVie, Adicet Bio, InnoCare
Pharma Inc., Guangzhou Lupeng Pharmaceutical Company LTD., BeiGene,
Nurix, LegoChem Biosciences, Xynomic Pharmaceuticals, Merck & Co, Incyte
Corporation, TG Therapeutics, Janssen/Pharmacyclics, Eternity
Bioscience, Traws Pharm, Advenchen Laboratories, and others are
evaluating new mantle cell lymphoma drugs to improve the treatment
landscape.
-- Promising mantle cell lymphoma pipeline therapies such as Venetoclax,
ADI-001, Orelabrutinib, LP-168, BGB-11417, NX 2127, LCB 71, NX 5948,
Abexinostat, Pembrolizumab, Parsaclisib, Umbralisib, Ibrutinib,
Edralbrutinib, Narazaciclib, Lucitanib, and others are under different
phases of mantle cell lymphoma clinical trials.
-- In May 2024, AstraZeneca had announced positive interim results from the
Phase III ECHO clinical trial, which evaluated Bruton's tyrosine kinase
(BTK) inhibitor Calquence (acalabrutinib) in combination with standard
chemoimmunotherapy for treating mantle cell lymphoma (MCL).
-- In March 2024, BeiGene, Ltd. announced the presentation of emerging
oncology pipeline data at the American Association for Cancer Research
(AACR) Annual Meeting. Additional highlights include preclinical
characterization data for an investigational BTK degrader, BGB-16673,
currently in clinical development for B-cell malignancies, including
mantle cell lymphoma
-- In October 2023, Ascentage Pharma announced that it has entered into a
clinical collaboration with AstraZeneca Investment. The two companies
will jointly conduct a registrational Phase III study of the Bcl-2
inhibitor, APG-2575 (lisaftoclax), in combination with AstraZeneca's
Bruton's tyrosine kinase (BTK) inhibitor, CALQUENCE® (acalabrutinib),
in treatment-naive patients with first-line chronic lymphocytic
leukemia/small lymphocytic lymphoma (CLL/SLL).
-- In January 2023, the FDA granted an orphan drug designation to LP-284, a
novel small-molecule, next-generation acylfulvene, for the treatment of
mantle cell lymphoma (MCL), a rare and aggressive form of B-cell
non-Hodgkin lymphoma (NHL), according to an announcement from Lantern
Pharma.
Request a sample and discover the recent advances in mantle cell lymphoma treatment drugs @ Mantle Cell Lymphoma Pipeline Report
The mantle cell lymphoma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage mantle cell lymphoma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the mantle cell lymphoma clinical trial landscape.
Mantle Cell Lymphoma Overview
Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphomas (NHLs) characterized by the (11,14) translocation, leading to overexpression of the cyclin D1 (CCND1) gene. Its various morphological variants can make diagnosis challenging, though some cases are straightforward. Many individuals with MCL are asymptomatic in the early stages, but may later seek medical attention due to persistent, typically painless swelling of lymph nodes, especially in the neck and throat region (e.g., Waldeyer's ring).
MCL is marked by a reciprocal chromosomal translocation t(11;14)(q13;q32), which places the cyclin D1 gene next to the immunoglobulin heavy chain gene, causing continuous cyclin D1 expression. This overexpression contributes to tumor cell proliferation through cell cycle dysregulation, chromosomal instability, and epigenetic changes. Rarely, MCL cases without this translocation may involve CCND2 or CCND3 translocations. Hypothetical molecular subtypes, based on the cell of origin, correlate with clinical phenotypes: classical or aggressive MCL arises from naive B cells lacking or having limited iGVH mutations and expressing SOX11, a neural transcription factor inhibiting terminal B cell differentiation. The indolent variant originates from antigen-experienced B cells with IGVH somatic hypermutations, typically SOX11-negative and genetically stable. Diagnosis of MCL involves detailed patient history, thorough clinical evaluation, and specialized tests, including biopsy of an affected lymph node or bone marrow. These tests confirm the NHL type and subtype, assess disease extent, and determine appropriate treatments.
Treatment for MCL is multifaceted and tailored to each patient, often including chemotherapy, immunotherapy drugs like rituximab, targeted therapies such as ibrutinib, and stem cell transplants, particularly for aggressive disease or younger patients. Radiation therapy may target specific lymphoma areas. Participation in clinical trials can offer new treatment options. Treatment plans are developed collaboratively by healthcare professionals and patients, considering disease stage, overall health, and personal preferences. Regular monitoring and follow-up care are essential to track treatment response and manage side effects effectively.
Find out more about mantle cell lymphoma treatment drugs @ Drugs for Mantle Cell Lymphoma Treatment
A snapshot of the Mantle Cell Lymphoma Pipeline Drugs mentioned in the report:
Drugs Company Phase
MoA RoA
Venetoclax
AbbVie Phase
III
Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors Oral
Sonrotoclax
BeiGene Phase II
Proto-oncogene protein c-bcl-2 inhibitors Oral
Rocbrutinib Newave
Pharmaceutical Phase II
Agammaglobulinemia tyrosine kinase inhibitors Oral
NX 2127
Nurix Phase I Agammaglobulinemia tyrosine kinase degraders; Agammaglobulinemia tyrosine
kinase inhibitors; Oral
ADI-001
Adicet Bio Phase I
Immunologic cytotoxicity; T lymphocyte replacements Intravenous
Learn more about the emerging mantle cell lymphoma pipeline therapies @ Mantle Cell Lymphoma Clinical Trials
Mantle Cell Lymphoma Therapeutics Assessment
The mantle cell lymphoma pipeline report proffers an integral view of the mantle cell lymphoma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Mantle Cell Lymphoma Pipeline Report
-- Coverage: Global
-- Therapeutic Assessment By Product Type: Mono, Combination,
Mono/Combination
-- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical,
Phase I, Phase II, Phase III
-- Therapeutics Assessment By Route of Administration: Oral, Parenteral,
Intravenous, Subcutaneous, Topical
-- Therapeutics Assessment By Molecule Type: Recombinant fusion proteins,
Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
-- Therapeutics Assessment By Mechanism of Action: Apoptosis stimulants,
Proto-oncogene protein c-bcl-2 inhibitors, Proteasome inhibitors,
Immunologic cytotoxicity, T lymphocyte replacements, Agammaglobulinemia
tyrosine kinase inhibitors
-- Key Mantle Cell Lymphoma Companies: AbbVie, Adicet Bio, InnoCare Pharma
Inc., Guangzhou Lupeng Pharmaceutical Company LTD., BeiGene, Nurix,
LegoChem Biosciences, Xynomic Pharmaceuticals, Merck & Co, Incyte
Corporation, TG Therapeutics, Janssen/Pharmacyclics, Eternity
Bioscience, Traws Pharm, Advenchen Laboratories, and others
-- Key Mantle Cell Lymphoma Pipeline Therapies: Venetoclax, ADI-001,
Orelabrutinib, LP-168, BGB-11417, NX 2127, LCB 71, NX 5948, Abexinostat,
Pembrolizumab, Parsaclisib, Umbralisib, Ibrutinib, Edralbrutinib,
Narazaciclib, Lucitanib, and others
Dive deep into rich insights for new drugs for mantle cell lymphoma treatment, visit @ Mantle Cell Lymphoma Drugs
Table of Contents
1. Mantle Cell Lymphoma Pipeline Report Introduction
2. Mantle Cell Lymphoma Pipeline Report Executive Summary
3.
Mantle Cell Lymphoma Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Mantle Cell Lymphoma Clinical Trial Therapeutics
6. Mantle Cell Lymphoma Pipeline: Late-Stage Products (Pre-
registration)
7. Mantle Cell Lymphoma Pipeline: Late-Stage Products
(Phase III)
8. Mantle Cell Lymphoma Pipeline: Mid-Stage Products (Phase
II)
9. Mantle Cell Lymphoma Pipeline: Early-Stage Products
(Phase I)
10. Mantle Cell Lymphoma Pipeline Therapeutics Assessment
11. Inactive Products in the Mantle Cell Lymphoma Pipeline
12. Company-University Collaborations (Licensing/
Partnering) Analysis
13.
Key Companies
14. Key Products in the Mantle Cell Lymphoma Pipeline
15.
Unmet Needs
16.
Market Drivers and Barriers
17.
Future Perspectives and Conclusion
18.
Analyst Views
19.
Appendix
For further information on the mantle cell lymphoma pipeline therapeutics, reach out @ Mantle Cell Lymphoma Treatment Drugs
Related Reports
B-Cell Lymphoma Epidemiology Forecast - 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology as well as the B-cell lymphoma epidemiology trends.
B-Cell Lymphoma Market Insights, Epidemiology, and Market Forecast - 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key B-cell lymphoma companies, including Vincerx Pharma, Ubix Therapeutics, Biomea Fusion Inc, Shanghai Hengrui Pharmaceutical, BeiGene, Hanmi Pharmaceutical, among others.
Diffuse Large B-Cell Lymphoma Pipeline
Diffuse Large B-Cell Lymphoma Pipeline Insight - 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key DLBCL companies, including Genmab, Roche, Acerta Pharma, Autolus, Xynomic Pharmaceuticals, Genentech, Celgene, AbbVie, Mabion, among others.
Diffuse Large B-Cell Lymphoma Market
Diffuse Large B-Cell Lymphoma Market Insights, Epidemiology, and Market Forecast - 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key B-cell lymphoma companies, including AbbVie, Genmab, Merck, Roche, Xencor and Janssen, Denovo Biopharma, Calithera Biosciences, IMV, Biogen, Autolus Therapeutics, Allogene Therapeutics, Novartis, Miltenyi Biomedicine, Regeneron Pharmaceuticals, among others.
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.
Contact Us
Shruti Thakur
info@delveinsight.com
+14699457679
www.delveinsight.com
Logo: https://mma.prnewswire.com/media/1082265/DelveInsight_Logo.jpg
View original content:https://www.prnewswire.com/news-releases/mantle-cell-lymphoma-clinical-trial-pipeline-insights-featuring-20-companies--delveinsight-302252717.html
SOURCE DelveInsight Business Research, LLP
