Florida Cancer Specialists & Research Institute Driving Global Progress in Cancer Care Discoveries
Thirteen Researchers Present Cutting-Edge Studies At 2025 ASCO(®) Annual Meeting
2025 ASCO(®) Annual Meeting abstracts featuring FCS research: 516, 2515, 2536 3000, 3009, 3010, 3011, 3030, 3033, 3041, 3042, 3124, 3151, 3517, 3553, 3579, 4006, 5502, 5503, 5523, 5551, 5599, 6024, 8519, 8589, 8598, e23219, e23550, TPS517, TPS1141, TPS3175, TPS5618, TPS8124, TPS8663
FORT MYERS, Fla., May 29, 2025 /PRNewswire/ -- Findings from 34 clinical research studies conducted at Florida Cancer Specialists & Research Institute, LLC (FCS) are among the groundbreaking scientific advances in cancer care that will be featured as oncology professionals from around the world gather this week at the 2025 American Society of Clinical Oncology (ASCO®) Annual Meeting in Chicago.
Thirteen physicians and leaders from the statewide practice will present the outcomes of early and late-phase clinical trials concluded during the past year at three FCS Phase 1 Drug Development Units and FCS clinics throughout Florida.
Research conducted at FCS is made possible through valuable relationships with Sarah Cannon Research Institute, one of the world's leading clinical research organizations, and Paradigm Health, an AI-enabled clinical trial matching and recruitment platform.
FCS President & Managing Physician Lucio N. Gordan, MD said, "Our robust research program sets us apart from other community oncology practices and is a cornerstone of our mission to deliver convenient access to world-class cancer care."
"The research findings being presented span new approaches alongside cutting-edge targeted therapies," said FCS Director of Drug Development Manish R. Patel, MD. "We continue to uncover scientific knowledge that is advancing precision oncology and enhancing outcomes for multiple cancer types, including rare and advanced forms of the disease."
The following FCS principal investigators are first authors of five abstracts that will be presented throughout the meeting:
-- Manish R. Patel, MD
-- First-in-human (FIH) phase 1 study of CUSP06, a cadherin-6
(CDH6)-directed antibody-drug conjugate (ADC), in patients with
platinum-refractory/resistant ovarian cancer and other advanced
solid tumors
-- ZL-1310, a DLL3 ADC, in patients with extensive stage small cell
lung cancer: Ph1 trial update.
-- Cesar Augusto Perez, MD, FCS director of drug development, Lake Nona
Drug Development Unit
-- First-in-human study of BG-C9074, a B7-H4-targeting ADC in patients
with advanced solid tumors: Preliminary results of the
dose-escalation phase
-- Judy Wang, MD, FCS associate director of drug development, Sarasota Drug
Development Unit
-- Efficacy and safety results of a multi-center phase I study of
utidelone capsule, a novel oral microtubule inhibitor, in advanced
solid tumor patients
-- An open-label, phase I trial of the SIRP monoclonal antibody, BI
770371, alone and in combination with the PD-1 inhibitor ezabenlimab
in patients with advanced solid tumors
The following FCS principal investigators have co-authored 31 additional abstracts and publications of research results and other clinical findings featured throughout the annual meeting:
-- Barry Berman, MD, MS
-- E7386 study 102: Global dose-expansion cohort of E7386 + lenvatinib
(LEN) in patients (pts) with advanced endometrial cancer (aEC) that
progressed on platinum-based chemotherapy (chemo) and an
anti-PD-(L)1 immunotherapy (IO).
-- Lowell Hart, MD, FACP
-- Efficacy and safety of ribociclib (RIB) + nonsteroidal aromatase
inhibitor (NSAI) in NATALEE: Analysis across menopausal status and
age
-- Lucio N. Gordan, MD; Josh Eaves, FCS chief development & strategy
officer; Kiana Mehring, FCS senior director, strategic partnerships -
managed care
-- National Comprehensive Cancer Network guideline compliance in an
oncology value-based care program serving Medicare members.
-- Maen Hussein, MD, FCS medical director, value-based care
-- LODESTAR: A single-arm phase II study of rucaparib in solid tumors
with pathogenic germline or somatic variants in homologous
recombination repair genes
-- Depth of response and progression-free survival in patients with
advanced ALK-positive non-small-cell lung cancer treated with
lorlatinib.
-- TIGOS-LS, an open-label, randomized study of BMS-986489 vs
durvalumab as consolidation therapy following chemoradiotherapy in
limited-stage small-cell lung cancer.
-- Bradley Monk, MD, FCS medical director of late-phase clinical research
-- Ultrasensitive detection and tracking of circulating tumor DNA
(ctDNA) and association with relapse and survival in locally
advanced cervical cancer (LACC): Phase 3 CALLA trial analyses
-- * Also published in the Annals of Oncology
-- Patient-reported outcomes (PROs) in locally advanced cervical cancer
(LACC): Insights from the OUTBACK trial.
-- miRNA(s) expression as predictive biomarkers in recurrent/metastatic
cervical cancer: The NRG Oncology/GOG-0240 NIH Cancer Moonshot.
-- Impact of disease progression on health-related quality of life
(HRQOL): Updated results from the PRIMA/ENGOT-OV26/GOG-3012 trial of
niraparib first-line (1L) maintenance therapy in patients with newly
diagnosed advanced ovarian cancer (aOC).
-- TroFuse-020/GOG-3101/ENGOT-cx20: A phase 3, randomized,
active-controlled, open-label, multicenter study comparing
sacituzumab tirumotecan monotherapy vs treatment of physician's
choice as second-line treatment for recurrent or metastatic cervical
cancer.
-- Ultrasensitive detection and tracking of circulating tumor DNA to
predict relapse and survival in patients with locally advanced
cervical cancer: phase III CALLA trial analyses
-- Relacorilant and nab-paclitaxel in patients with platinum-resistant
ovarian cancer (ROSELLA): a phase 3, randomised, controlled,
open-label trial (Published in The Lancet)
-- Manish R. Patel, MD
-- Safety and efficacy of ADG126 (an anti-CTLA-4 masking antibody) in
combination with pembrolizumab: Updated results of phase 1b/2 study
in advanced MSS CRC
-- Ivor Percent, MD
-- Preliminary results from the randomized phase 2 study (1801 part 3B)
of elraglusib in combination with gemcitabine/nab-paclitaxel (GnP)
versus GnP alone in patients (pts) with previously untreated
metastatic pancreatic ductal adenocarcinoma (mPDAC)
-- Cesar Augusto Perez, MD
-- DB-1310, a HER3-targeted ADC, in pts with advanced solid tumors:
Preliminary results from the phase 1/2a trial.
-- Sigvotatug vedotin (SV), an investigational integrin beta-6
(IB6)-directed antibody?drug conjugate (ADC), and pembrolizumab
combination therapy: Initial results from an ongoing phase 1 study
(SGNB6A-001).
-- BMS-986504 in patients (pts) with advanced solid tumors with
homozygous MTAP deletion (MTAP-del): Clinical update and first
report of pharmacokinetics (PK) and pharmacodynamic (PD) analyses
from CA240-0007.
-- Safety and efficacy of olomorasib + immunotherapy in first-line
treatment of patients with KRAS G12C-mutant advanced NSCLC: Update
from the LOXO-RAS-20001 trial.
-- Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4
inhibitor, in patients with advanced solid tumors: Results on
safety, pharmacokinetics, and anti-tumor activity.
-- Vilastobart (XTX101), a tumor-activated, Fc-enhanced anti-CTLA-4
monoclonal antibody, in combination with atezolizumab in patients
with MSS CRC
-- Petosemtamab (MCLA-158) with pembrolizumab as first-line (1L)
treatment of PD-L1+ recurrent/metastatic (r/m) head and neck
squamous cell carcinoma (HNSCC): Phase 2 trial
-- Alexander Philipovskiy, MD, PhD
-- Phase 2 dose expansion study of DSP107, a first-in-class bi-specific
4-1BB T-cell engager, with and without atezolizumab in metastatic
MSS colorectal cancer patients
-- Preclinical and phase 1/2 data of the CHK1 inhibitor BBI-355 in
development for esophageal and gastric cancers (EGC) with EGFR or
FGFR2 amplifications
-- A phase 1/2 open-label, multicenter, first-in-human study of the
safety, tolerability, pharmacokinetics, and antitumor activity of
BH-30643 in adult subjects with locally advanced or metastatic NSCLC
harboring EGFR and/or HER2 mutations (SOLARA).
-- Judy Wang, MD
-- Initial phase 1 dose escalation data for emiltatug ledadotin
(Emi-Le), a novel B7-H4-directed dolasynthen antibody-drug conjugate
-- Final results of a phase 1 study of EP0031, a next generation
selective RET inhibitor (SRI) in patients with SRI naïve or
pretreated advanced RET-altered tumors.
-- Emiltatug ledadotin (Emi-Le): A B7-H4-directed dolasynthen
antibody-drug conjugate (ADC) being investigated in phase 1 dose
expansion in patients with triple negative breast cancer who
received at least one prior topoisomarase-1 inhibitor ADC.
-- A phase 1 study to evaluate the safety, pharmacokinetics, and
efficacy of the first-in-class cyclin A/B RxL inhibitor CID-078, an
orally bioavailable, cell-permeable macrocycle
-- Artificial intelligence (XGBoost) in predicting outcomes among CAR-T
therapy patients: The impact of malnutrition and comorbidities using
the National Inpatient Sample (2020-2022).
-- Faye Yin, MD
-- Artificial intelligence (XGBoost) in predicting outcomes among CAR-T
therapy patients: The impact of malnutrition and comorbidities using
the National Inpatient Sample (2020-2022).
-- Survival of malignant peripheral nerve sheath tumor of the trachea,
mediastinum, and other respiratory organs: Analysis of SEER database
"Our pioneering research and late-phase trials are transforming clinical practice," said Bradley Monk, MD, gynecologic oncologist and FCS medical director of late-phase clinical research. "Every discovery sharpens our ability to deliver more precise, effective treatments."
FCS Chief Executive Officer Nathan H. Walcker said, "The ASCO(®) annual meeting showcases the top research of the year from around the globe and FCS is proud to again be recognized at the forefront of shaping the future of cancer care."
All abstracts and presentations are available to view at ASCO® 2025 Annual Meeting.
The American Society of Clinical Oncology (ASCO(®)) represents nearly 50,000 physicians and oncology professionals representing 150 countries who care for people living with all forms of cancer. ASCO(®) works to conquer cancer through research, education, policy and promotion of high quality and equitable patient care.
About Florida Cancer Specialists & Research Institute, LLC: (FLCancer.com)
For more than 40 years, Florida Cancer Specialists & Research Institute (FCS) has embraced innovation to deliver world-class care and drive the dramatic transformation of oncology care through its robust clinical research program.
FCS provides patients with access to a wide range of clinical trials, positioning it as a leader in research among private oncology practices in Florida and across the country. In fact, before receiving FDA approval, the majority of new cancer drugs in the U.S. were first made available to patients through participation in clinical trials at FCS.
Our outstanding team of highly trained and dedicated physicians is committed to delivering tailored treatment plans that make the best use of cutting-edge precision oncology advancements to enhance patient outcomes.
View original content to download multimedia:https://www.prnewswire.com/news-releases/florida-cancer-specialists--research-institute-driving-global-progress-in-cancer-care-discoveries-302468311.html
SOURCE Florida Cancer Specialists & Research Institute
