The Market and Potential for CRISPR/Cas9 Gene Editing 2017-2023

The Market and Potential for CRISPR/Cas9 Gene Editing 2017-2023

DUBLIN, April 12, 2018 /PRNewswire/ --

The "The Market and Potential for CRISPR/Cas9 Gene Editing" report has been added to ResearchAndMarkets.com's offering.

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In 2018, more than 30 players participate in this market, from large multinational corporations to small, niche life sciences companies. Key players include Agilent, MilliporeSigma, GE Healthcare Dharmcon, GeneScript, Horizon Discovery Group, OriGene, ThermoFisher Scientific, Transposagen, and ToolGen. These companies develop and commercialize various products and services for each of the major gene editing technologies.

The nature of CRISPR's complex technology requires partnerships between the developers of the technology and the healthcare concerns with distribution strength and a broader product base. These developments are outlined in the report.

Currently, one of the more significant factors in commercializing CRISPR-Cas9 as a viable therapeutic tool is the current legal battles surrounding the technology. The issue started when both the University of California, Berkeley (UCB) and the Broad Institute of MIT (the Broad) both filed patents related to this technology. While there's been some resolution, the report provides an analysis of developments.

Report Scope

    --  Market Size and Forecast for CRISPR/Cas9 Gene Editing, 2017-2023
    --  The Market for CRISPR/Cas9 by Region (N. Amer. EU, ROW), 2017-2023
        Analysis of Growth Trend by Region
    --  Market by Application (Cancer Research, Non-Cancer Disease Research,
        Cancer Diagnostics, Infection Diagnostics, Plant, Food, Biofuel, Drug
        Discovery, Drug Development, Other)
    --  Growth Trend, U.S.
    --  Growth Trend, Outside U.S.
    --  Market by End User (Hospitals, University, Medical Research Institute,
        Government), 2017
    --  Market by End User (Hospitals, University, Medical Research Institute,
        Government), 2023
    --  Recent Technology and Market Developments and Medical Studies
    --  Partnerships Involving CRISPR Gene Editing

Companies Mentioned

    --  Adverum
    --  Allergan plc
    --  AstraZeneca
    --  Bayer
    --  Bioverativ Inc.
    --  BlueBird Biotechnologies
    --  CRISPR Therapeutic
    --  Caribou Biosciences, Inc.
    --  Casebia Therapeutics
    --  Cellectis, Inc.
    --  CureVac AG
    --  Editas Medicine
    --  Exonics Therapeutics
    --  GenScript
    --  Homology Medicines
    --  Intellia Therapeutics
    --  Juno Therapeutics
    --  Merck
    --  Neon Therapeutics
    --  Novartis
    --  NovellusDx
    --  Pfizer Inc.
    --  Poseida Therapeutics
    --  Precision Biosciences
    --  Recombinetics
    --  Regeneron Pharmaceuticals
    --  Sarepta Therapeutics
    --  Seattle Children's Research
    --  Servier
    --  Shire International
    --  Synthego
    --  The Innovative Genomics Initiative
    --  Thermo Fisher Scientific
    --  Twist Bioscience, Desktop Genetics

    --  Vertex Pharmaceuticals

Recent CRISPR Market Developments

    --  The most important funding source that fuels a market for research
        instrumentation is funding from the National Institutes of Health. The
        following table details grants for CRISPR-based projects, which in 2015
        represented 267 million and in 2017 expanded to over 1 billion. Outside
        the U.S., there is additional research dollars.
    --  CRISPR-Cas9-based technologies have strongly increased genome
        engineering efficiencies in bacteria. This has enabled more rapid
        metabolic engineering of both the model host Escherichia coli and
        non-model organisms like Clostridia, Bacilli, Streptomycetes and
        cyanobacteria, opening new possibilities to use these organisms as
        improved cell factories. The discovery of novel Cas9-like systems from
        diverse microbial environments will extend the repertoire of
        applications and broaden the range of organisms in which it can be used
        to create novel production hosts.
    --  In December 2017, Vertex Pharmaceuticals and CRISPR Therapeutics
        announced that the companies will co-develop and co-commercialize
        CTX001, an investigational gene editing treatment, as part of the
        companies' previously announced collaboration aimed at the discovery and
        development of new gene editing treatments that use the CRISPR/Cas9
        technology. CTX001 represents the first gene-based treatment that Vertex
        exclusively licensed from CRISPR Therapeutics as part of the
        collaboration.
    --  GE Healthcare Dharmacon offers an arrayed synthetic form of CRISPR/Cas9
        that allows many different assays (e.g., enzymatic, endpoint, secreted
        factors) to be performed without resorting to antibiotic selection, long
        time points, or cell splitting. The system designs at least four
        different guide RNAs per gene, according to the company, so that if the
        same effect is seen using all four of the guide RNAs for the same gene,
        then the results are more likely to be biologically relevant.
    --  January 2017, the FDA proposed draft guidance suggesting modifications
        intentionally introduced into animal genomes should be regulated in a
        manner comparable to new drugs, meaning developers would have to show
        efficacy, animal and human safety, and safety for the environment.
    --  In late April 2017, researchers from the Broad Institute of MIT and
        Harvard, other institutes and departments at MIT (Massachusetts
        Institute of Technology) and Harvard, Howard Hughes Medical Institute,
        and the National Center for Biotechnology Information, National Library
        of Medicine, National Institutes of Health published an article in
        Science entitled Nucleic acid detection with CRISPR-Cas13a/C2c2. In this
        article, they describe a CRISPR-based diagnostic (CRISPR-Dx) which they
        called Specific High-Sensitivity Enzymatic Reporter UnLOCKing
        (SHERLOCK). This platform combines the Cas13a enzyme (which targets RNA)
        with isothermal amplification. They authors used this platform to detect
        the Zika and Dengue virus, pathogenic bacteria, cell-free tumor DNA, and
        other genetic targets. The lead author for this paper is Feng Zhang,
        Ph.D. (Broad Institute), one of the pioneers in CRISPR research

Key Topics Covered

1. Executive Summary

    --  Overview
    --  gRNA
    --  Enzyme
    --  NIH Grants for CRISPR Projects
    --  CRISPR/Cas9 NIH Projects by End User
    --  Industry Risk Analysis - Patent Landscape
    --  Impact of the Initial Ruling
    --  How Things Stand Now in the US
    --  How Things Stand in Europe
    --  Conclusions
    --  Other Recent CRISPR/Cas9 Developments
    --  The Market for CRISPR Equipment and Supplies
    --  Market by Geography
    --  Trends in Gene Editing
    --  Significant Partnerships in Gene Editing

2. CRISPR Products and Trends

    --  Overview
    --  Advantages and Disadvantages of CRISPR
    --  Recent Applications and Developments
    --  Malaria Control
    --  Gene-Edited Sheep for Regenerative Medicine
    --  Improved Vaccine Creation
    --  Obesity Control
    --  Epstein-Barr Virus
    --  Protein Coding
    --  Improving Chinese Herbs
    --  Identifying Drug Resistance Mutations
    --  Immune Therapies for Cancer
    --  Enabling Bacterial Cell Factories
    --  Muscular Dystrophy
    --  "Piggy Bac" Process for Stem Cells
    --  Clarity on Salmonella Ser. Kentucky
    --  Better Human Disease Models
    --  Editing of Bread Wheat
    --  Cancer Cell Phagocytosis
    --  Refining Gene Editing
    --  Companies in CRISPR Gene Editing
    --  Commercial Applications of Gene Editing Technologies
    --  Using CRISPR for Diagnostics
    --  Using CRISPR for Human Therapeutics
    --  Selected CRISPR-Cas9 Gene Editing Products
    --  CRISPR Companies
    --  Agilent
    --  Allele Biotechnology
    --  Applied Biological Materials
    --  Dharmacon
    --  DNA 2.0
    --  GeneCopoeia
    --  GenScript
    --  Horizon Discovery Group, Plc
    --  Integrated DNA Technologies
    --  MilliporeSigma
    --  OriGene
    --  PNA Bio
    --  Santa Cruz Biotechnology
    --  System BioSciences
    --  Takara Bio (Clontech)
    --  ThermoFisher Scientific
    --  ToolGen
    --  TriLink Biotechnology

3. Gene Editing Market Analysis

    --  Market Analysis Commentary
    --  The Market for CRISPR Equipment and Supplies
    --  Market by Geography
    --  Growth Trend
    --  Growth Trend in North America and Europe
    --  Growth Trend in the Rest of the World
    --  Market by Application
    --  Market by End User

4. Gene Editing Partnerships

    --  Caribou Biosciences, Inc.
    --  Sangamo Biosciences
    --  Shire International
    --  Pfizer Inc.
    --  Bioverativ Inc.
    --  CRISPR Therapeutics
    --  Bayer
    --  Vertex Pharmaceuticals
    --  MaSTherCell
    --  Neon Therapeutics
    --  Massachusetts General Hospital Cancer Center
    --  CureVac AG
    --  Editas Medicine
    --  Allergan plc
    --  Adverum
    --  Juno Therapeutics
    --  Intellia Therapeutics
    --  Regeneron Pharmaceuticals
    --  Novartis
    --  Precision Biosciences
    --  BlueBird Biotechnologies
    --  Christiana Care's Gene Editing Institute
    --  The Wistar Institute
    --  NovellusDx
    --  Analytical Biological Services
    --  Casebia Therapeutics
    --  CRISPR Therapeutics and MaxCyte
    --  Seattle Children's Research
    --  CRISPR Therapeutics and CureVac AG
    --  Synthego
    --  Thermo Fisher Scientific
    --  Sarepta Therapeutics
    --  Homology Medicines
    --  GenScript
    --  Cellectis, Inc.
    --  Pfizer
    --  Servier
    --  Merck
    --  Twist Bioscience, Desktop Genetics
    --  AstraZeneca
    --  The Wellcome Trust Sanger Institute
    --  The Innovative Genomics Initiative
    --  Thermo Fisher Scientific
    --  Broad Institute / Whitehead Institute
    --  Increasing Investments and Funding in Gene Editing Area to Augment
        Market Revenues
    --  Exonics Therapeutics
    --  Synthego
    --  Homology Medicines
    --  Editas Medicine
    --  Intellia Therapeutics
    --  CRISPR Therapeutics
    --  Poseida Therapeutics
    --  Recombinetics

For more information about this report visit https://www.researchandmarkets.com/research/7mdg55/the_market_and?w=5

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