Intrexon Reports 2018 Fourth Quarter and Year End Financial Results

GERMANTOWN, Md., Feb. 28, 2019 /PRNewswire/ -- Intrexon Corporation (NASDAQ: XON), a leader in the engineering and industrialization of biology to improve the quality of life and health of the planet, today announced its fourth quarter and full year financial results for 2018.

Recent Business Highlights:

    --  Precigen, Inc., a wholly owned subsidiary of Intrexon, announced the US
        Food and Drug Administration (FDA) cleared the Investigational New Drug
        (IND) application for PRGN-3006, an investigational drug for patients
        with relapsed or refractory acute myeloid leukemia (AML) and higher risk
        myelodysplastic syndrome (MDS). PRGN-3006 is an autologous chimeric
        antigen receptor T-cell (CAR-T) therapeutic candidate utilizing
        Precigen's transformative UltraCAR-T((TM)) platform, which reduces
        manufacturing time to within two days following non-viral gene transfer;
    --  Precigen announced the FDA cleared the IND application for PRGN-3005
        UltraCAR-T((TM)), an investigational drug using CAR-T cells to treat
        advanced-stage platinum-resistant ovarian cancer patients and the first
        UltraCAR-T((TM)) candidate targeting solid tumors to enter the clinic;
    --  Following the previously reported reacquisition of oncology rights from
        Ziopharm in October 2018, Precigen and Intrexon entered into an
        agreement with Merck KGaA, Darmstadt, Germany, a leading science and
        technology company, and its wholly owned subsidiary Ares Trading,
        pursuant to which Intrexon assumed rights from Ares Trading under the
        existing agreement among Precigen, Ares Trading and Ziopharm relating to
        the development of CAR-T therapies. In addition to receiving 20,640,119
        shares of Intrexon common stock, the agreement also included a further
        $25 million investment in the Company. In return, Merck KGaA, Darmstadt,
        Germany, received a $25 million convertible note, providing the option
        to receive either Precigen or Intrexon common stock;
    --  Xogenex, a majority owned subsidiary of Intrexon, has completed an
        evaluation of three advanced heart failure patients who were
        administered INXN-4001, an investigational, non-viral, plasmid-based
        gene drug candidate designed to drive expression of three cardiac
        effector genes involved in heart failure, in a Phase 1 clinical trial.
        The data reflected the patients' status six-months after being given the
        INXN-4001 and appears to indicate that the drug material and the
        delivery process were both well tolerated by the patients. Preliminary
        review of the data suggests improvements in several cardiac performance
        parameters;
    --  Intrexon's methane bioconversion platform is being employed to produce
        2,3 BDO from natural gas and has achieved 80% of the goal for the first
        small-scale plant operations;
    --  Detailed engineering design for Intrexon's first-of-a-kind small-scale
        methane bioconversion facility to 2,3 BDO is currently being bid out,
        discussions with partners for sites are ongoing. The overall schedule is
        still consistent as the sites under consideration are brownfield which
        require less engineering time than the original greenfield concept;
    --  Exemplar Genetics, a wholly owned subsidiary of Intrexon, announced the
        launch of a joint venture with the Mayo Clinic, which is focused on the
        development of a high-quality source of human liver cells or hepatocytes
        (HHCs);
    --  Trans Ova Genetics, a wholly owned subsidiary of Intrexon, continues to
        expand and improve its herd genetics with two Jersey heifers ranking
        2(nd) and 9(th) in the world and 15 bulls that rank at the top of the
        global Holstein bull population;
    --  EnviroFlight, Intrexon's joint venture with Darling Ingredients Inc.,
        opened the very first commercial Black Soldier Fly (BSFL) facility, in
        Maysville, Kentucky in November 2018. The production plant has the
        ability to produce 900 tonnes/year of dried BSFL, and orders for product
        from the new facility account for one-third of the anticipated annual
        output;
    --  Okanagan Specialty Fruits, a wholly owned subsidiary of Intrexon,
        harvested more than 2,100 bins of Arctic(®) apples in their 2018
        harvest, which are available at select retailers as fresh sliced apples
        and ApBitz((TM)) dehydrated apple snacks, and is planning to plant up to
        1,000,000 trees in the spring of 2019;
    --  Intrexon entered into a strategic licensing agreement with Next Green
        Wave Holdings Inc. to utilize Intrexon's Botticelli(TM) next generation
        plant propagation platform to enable rapid production of Next Green
        Wave's proprietary cannabis cultivars for the California market;
    --  Oxitec, Ltd., a wholly owned subsidiary of Intrexon, announced that it
        will be transitioning from its 1st generation self-limiting
        Friendly((TM)) Aedes aegypti mosquito (OX513A) to a new Friendly((TM))
        Aedes mosquito (OX5034) that uses Oxitec's 2nd generation technology,
        allowing the company to focus on advancing its entire mosquito and crop
        pest portfolios using this next-generation platform; and
    --  Oxitec has secured two multi-year development agreements with a partner
        to develop solutions for pest problems beyond the mosquito, which have
        the potential for application in key markets globally.

Fourth Quarter 2018 Financial Highlights:

    --  Total revenues of $43.2 million, a decrease of 44% from the fourth
        quarter of 2017;
    --  Net loss of $340.5 million attributable to Intrexon, or $(2.59) per
        basic share, including non-cash charges of $311.0 million;
    --  Adjusted EBITDA of $(27.2) million, or $(0.21) per basic share; and
    --  Cash, cash equivalents, and short-term investments totaled $222.5
        million and the value of common equity securities totaled $2.2 million
        at December 31, 2018.

Full Year 2018 Financial Highlights:

    --  Total revenues of $160.6 million, a decrease of 31% from the full year
        ended December 31, 2017;
    --  Net loss of $509.3 million attributable to Intrexon, or $(3.93) per
        basic share, including non-cash charges of $420.0 million; and
    --  Adjusted EBITDA of $(102.5) million, or $(0.79) per basic share.

"With several of the most ambitious stated objectives at the time of our IPO now achieved, most notably with our work in UltraCAR-T(TM) and in natural gas upgrading, our team is more energized than ever to establish its tangible value in the world," commented Randal J. Kirk, Chairman and Chief Executive Officer of Intrexon. "We expect to achieve this initially through independent equitization and/or monetization events at Precigen and from our Methane Bioconversion Platform, while other business units of our company may also find higher values independently of our company."

Mr. Kirk concluded, "It has always been our purpose to be an enabler of enterprise that is built on engineered biology and not to create an industrial conglomerate. In this we have succeeded greatly so we look forward to seeing some of our bold enterprises making their marks in the world. We are confident in our prospects to achieve this and that we have adequate cash resources to fuel us to these realizations."

Fourth Quarter 2018 Financial Results Compared to Prior Year Period

Total revenues decreased $33.8 million, or 44%, from the quarter ended December 31, 2017. Collaboration and licensing revenues decreased $30.9 million from the quarter ended December 31, 2017 due to (i) the mutual termination in 2017 of the Company's second exclusive channel collaboration (ECC) with Ziopharm for the treatment of graft-versus-host disease, (ii) a decrease in research and development services for certain of the Company's ECCs as the Company redeployed certain resources towards supporting prospective new platforms and partnering opportunities and began to focus more on the further development of relationships and structures that will provide the Company with more control and ownership over the development process and commercialization path, including programs where the Company reacquired the previously licensed technology rights in 2018, and (iii) a decrease in research and development services performed by the Company for collaborators upon the transition of program execution to its collaborators. Product revenues decreased $2.8 million or 36% primarily due to lower milk prices which resulted in lower customer demand for cows and cloned products. Gross margin on products declined in the current period as a result of decreased sales. Gross margin on services improved in the current period as a result of pricing changes and an increase in the number of embryos produced per bovine in vitro fertilization cycle due to improved production results.

Research and development expenses increased $242.0 million, or 628%, and include $228.0 million of expenses related to in-process research and development reacquired from former collaborators. Selling, general and administrative (SG&A) expenses decreased $7.9 million, or 24%. This decrease was primarily due to lower compensation expenses due to adjustments to previously accrued compensation expenses for performance and retention incentives for SG&A employees in 2018. The Company recorded an impairment charge of $60.5 million in the fourth quarter of 2018 due to a change in the Company's business strategy for commercializing the Oxitec technology targeting the Aedes aegypti mosquito.

Full Year 2018 Financial Results Compared to Prior Year Period

Total revenues decreased $70.4 million, or 31%, from the year ended December 31, 2017. Collaboration and licensing revenues decreased $68.7 million from the year ended December 31, 2017 primarily due to (i) the mutual termination in 2017 of the Company's second ECC with Ziopharm for the treatment of graft-versus-host disease, (ii) a decrease in research and development services for certain of the Company's ECCs as the Company redeployed certain resources towards supporting prospective new platforms and partnering opportunities and began to focus more on the further development of relationships and structures that provide the Company with more control and ownership over the development process and commercialization path, including programs where the Company reacquired the previously licensed technology rights in 2018, and (iii) a decrease in research and development services performed by the Company for collaborators upon the transition of program execution to its collaborators. Product revenues decreased $5.1 million or 15% primarily due to lower milk prices which in turn resulted in lower customer demand for live calves, cows previously used in production, and cloned products. Gross margin on products declined in the current period as a result of lower product sales and increased operating costs associated with new product offerings and cloned products. The increase in service revenues of $1.8 million, or 4%, as well as the gross margin thereon relates to pricing changes and an increase in the number of embryos produced per bovine in vitro fertilization cycle due to improved production results.

Research and development expenses increased $261.4 million, or 183%, and include $236.7 million of expenses related to in-process research and development reacquired from former collaborators. SG&A expenses decreased $8.3 million, or 6%, from the prior period. Legal and professional fees decreased $7.5 million primarily due to (i) decreased legal fees associated with ongoing litigation and (ii) decreased fees incurred for regulatory and other consultants. The Company recorded an impairment charge of $60.5 million in the fourth quarter of 2018 due to a change in the Company's business strategy for commercializing the Oxitec technology targeting the Aedes aegypti mosquito.

Total other income (expense), net, decreased $41.5 million, or 185%. This decrease was primarily attributable to losses on the Company's investment in Ziopharm preferred stock prior to returning this investment to Ziopharm in the fourth quarter of 2018, as well as an increase in interest expense related to the 3.5% convertible notes issued by the Company in the third quarter of 2018.

Based on Intrexon's financial position, including its cash, cash equivalents and short-term investments of $224 million at December 31, 2018, in connection with issuing its financial statements Intrexon expects to include a conclusion in its Form 10-K that there is substantial doubt about its ability to continue as a going concern.

Conference Call and Webcast

The Company will host a conference call today Thursday, February 28(th), at 5:30 PM ET to discuss the fourth quarter and full year 2018 financial results and provide a general business update. The conference call may be accessed by dialing 1-888-317-6003 (Domestic US), 1-866-284-3684 (Canada), and 1?412-317-6061 (International) and providing the number 4443860 to join the Intrexon Corporation Call. Participants may also access the live webcast through Intrexon's website in the Investors section at http://investors.dna.com/events.

About Intrexon Corporation

Intrexon Corporation (NASDAQ: XON) is Powering the Bioindustrial Revolution with Better DNA((TM)) to create biologically-based products that improve the quality of life and the health of the planet. Intrexon's integrated technology suite provides its partners across diverse markets with industrial-scale design and development of complex biological systems delivering unprecedented control, quality, function, and performance of living cells. We call our synthetic biology approach Better DNA(®), and we invite you to discover more at www.dna.com or follow us on Twitter at @Intrexon, on Facebook, and LinkedIn.

Non-GAAP Financial Measures

This press release presents Adjusted EBITDA and Adjusted EBITDA per share, which are non-GAAP financial measures within the meaning of applicable rules and regulations of the Securities and Exchange Commission (SEC). For a reconciliation of these measures to the most directly comparable financial measure calculated in accordance with generally accepted accounting principles and for a discussion of the reasons why the Company believes that these non-GAAP financial measures provide information that is useful to investors see the tables below under "Reconciliation of GAAP to Non-GAAP Measures." Such information is provided as additional information, not as an alternative to Intrexon's consolidated financial statements presented in accordance with GAAP, and is intended to enhance an overall understanding of the Intrexon's current financial performance.

Trademarks

Intrexon, Arctic, Botticelli, UltraCAR-T, Friendly, Powering the Bioindustrial Revolution with Better DNA, and Better DNA are trademarks of Intrexon and/or its affiliates. Other names may be trademarks of their respective owners.

Safe Harbor Statement

Some of the statements made in this press release are forward-looking statements that involve a number of risks and uncertainties and are made pursuant to the Safe Harbor Provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements made in this press release include, but are not limited to, statements regarding clinical and pre-clinical development activities by Intrexon and its collaborators, commercial and business development plans and the submission of regulatory filings. These forward-looking statements are based upon Intrexon's current expectations and projections about future events and generally relate to Intrexon's plans, objectives and expectations for the development of Intrexon's business. Although management believes that the plans and objectives reflected in or suggested by these forward-looking statements are reasonable, all forward-looking statements involve risks and uncertainties and actual future results may be materially different from the plans, objectives and expectations expressed in this press release. These risks and uncertainties include, but are not limited to, (i) Intrexon's strategy and overall approach to its business model, including its ability to successfully enter into optimal strategic relationships with its subsidiaries and operating companies that Intrexon may form in the future, its ability to develop prospective new platforms and partnering opportunities, and its ability to exercise more control and ownership over the development process and commercialization path; (ii) Intrexon's ability to successfully enter new markets or develop additional products, whether with its collaborators or independently; (iii) actual or anticipated variations in Intrexon's operating results; (iv) actual or anticipated fluctuations in Intrexon's competitors' or its collaborators' operating results or changes in their respective growth rates; (v) Intrexon's cash position; (vi) market conditions in Intrexon's industry; (vii) the volatility of Intrexon's stock price; (viii) Intrexon's ability, and the ability of its collaborators, to protect Intrexon's intellectual property and other proprietary rights and technologies; (ix) Intrexon's ability, and the ability of its collaborators, to adapt to changes in laws or regulations and policies; (x) the outcomes of pending or future litigation; (xi) the rate and degree of market acceptance of any products developed by a collaborator under an ECC or through a joint venture; (xii) Intrexon's ability to retain and recruit key personnel; (xiii) Intrexon's expectations related to the use of proceeds from its public offerings and other financing efforts; (xiv) Intrexon's estimates regarding expenses, future revenue, capital requirements and needs for additional financing; and (xv) Intrexon's expectations relating to its subsidiaries and other affiliates. For a discussion of other risks and uncertainties, and other important factors, any of which could cause Intrexon's actual results to differ from those contained in the forward-looking statements, see the section entitled "Risk Factors" in Intrexon's Annual Report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in Intrexon's subsequent filings with the SEC. All information in this press release is as of the date of the release, and Intrexon undertakes no duty to update this information unless required by law.

For more information regarding Intrexon Corporation, contact:



     
              Investor Contact:       
     
              Corporate Contact:


     Steven Harasym                     
     Marie Rossi, PhD


     Vice President, Investor Relations 
     Vice President, Communications


     Tel: +1 (214) 721-0607             
     Tel: +1 (301) 556-9850


     
              investors@dna.com       
     
              publicrelations@dna.com



                                                 
       
                Intrexon Corporation and Subsidiaries

                                                   
          
                Consolidated Balance Sheets

                                                       
              
                (Unaudited)





       
                (Amounts in thousands)           December 31,                                      December 31,
                                                              2018                                               2017

    ---


       
                Assets



       Current assets



       Cash and cash equivalents                                               $
              102,768                    $
          68,111



       Restricted cash                                                                       6,987                             6,987



       Short-term investments                                                              119,688                             6,273



       Equity securities                                                                       384                             5,285



       Receivables



       Trade, net                                                                           21,195                            19,775



       Related parties, net                                                                  4,129                            17,913



       Other, net                                                                            2,754                             2,153



       Inventory                                                                            21,447                            20,493



       Prepaid expenses and other                                                            6,131                             7,057






       Total current assets                                                                285,483                           154,047



       Equity securities, noncurrent                                                         1,798                             9,815



       Investments in preferred stock                                                          191                           161,225



       Property, plant and equipment, net                                                  128,874                           112,674



       Intangible assets, net                                                              129,291                           232,877



       Goodwill                                                                            149,585                           153,289



       Investments in affiliates                                                            18,859                            18,870



       Other assets                                                                          2,096                             4,054





       Total assets                                                            $
              716,177                   $
          846,851

    ---






       Current liabilities



       Accounts payable                                                         $
              13,420                     $
          8,701



       Accrued compensation and benefits                                                    10,687                             6,474



       Other accrued liabilities                                                            20,620                            21,080



       Deferred revenue                                                                     15,554                            42,870



       Lines of credit                                                                         466                               233



       Current portion of long-term debt                                                       559                               502



       Related party payables                                                                  256                               313






       Total current liabilities                                                            61,562                            80,173


        Long-term debt, net of current portion                                              211,235                             7,535


        Deferred revenue, net of current portion                                             54,210                           193,527



       Deferred tax liabilities, net                                                         7,213                            15,620



       Other long-term liabilities                                                           3,235                             3,451






       Total liabilities                                                                   337,455                           300,306






       Commitments and contingencies



       Total equity



       Common stock



       Additional paid-in capital                                                        1,722,012                         1,397,005



       Accumulated deficit                                                             (1,330,545)                        (847,820)



       Accumulated other comprehensive loss                                               (28,612)                         (15,554)






       Total Intrexon shareholders' equity                                                 362,855                           533,631



       Noncontrolling interests                                                             15,867                            12,914






       Total equity                                                                        378,722                           546,545






       Total liabilities and total equity                                      $
              716,177                   $
          846,851

    ---


                                                                        
              
              Intrexon Corporation and Subsidiaries

                                                                        
              
              Consolidated Statements of Operations

                                                                                     
            
                (Unaudited)





              
                (Amounts in thousands,                         Three months ended                                                                     Year ended
    except share and per share
    data)

    ---

                                                        December 
      31,                                                                              December 31,



                                                                   2018                                         2017                                                        2018                     2017






              
                Revenues



              Collaboration and licensing                                 $
              25,247                                         $
          56,195                                  $
          76,869           $
          145,579
         revenues



              Product revenues                                                         4,979                                                  7,809                                          28,528                    33,589



              Service revenues                                                        12,040                                                 12,721                                          52,419                    50,611



              Other revenues                                                             919                                                    303                                           2,758                     1,202




              Total revenues                                                          43,185                                                 77,028                                         160,574                   230,981






              
                Operating Expenses



              Cost of products                                                         7,652                                                  7,638                                          35,698                    33,263



              Cost of services                                                         6,462                                                  7,720                                          27,589                    29,525



              Research and development                                               280,514                                                 38,544                                         404,586                   143,207



              Selling, general and                                                    24,935                                                 32,845                                         137,807                   146,103
    administrative



              Impairment loss                                                         60,504                                                 16,773                                          60,504                    16,773




              Total operating expenses                                               380,067                                                103,520                                         666,184                   368,871




              Operating loss                                                       (336,882)                                              (26,492)                                      (505,610)                (137,890)






              
                Other Income (Expense), Net



              Unrealized and realized                                                (2,635)                                               (6,654)                                       (30,200)                    2,586
         appreciation
         (depreciation) in fair
         value of equity securities
         and preferred stock, net



              Interest expense                                                       (4,290)                                                 (113)                                        (8,530)                    (611)



              Interest and dividend income                                             1,761                                                  5,048                                          19,084                    19,485



              Other income (expense), net                                                 59                                                (3,440)                                            630                     1,013




              Total other income                                                     (5,105)                                               (5,159)                                       (19,016)                   22,473
         (expense), net



              Equity in net loss of affiliates                                       (1,728)                                               (3,010)                                       (11,608)                 (14,283)




              Loss before income taxes                                             (343,715)                                              (34,661)                                      (536,234)                (129,700)



              Income tax benefit                                                       1,993                                                    716                                          21,528                     2,880




              Net loss                                                 $
              (341,722)                                      $
          (33,945)                              $
          (514,706)        $
          (126,820)



              Net loss attributable to the                                             1,257                                                  6,679                                           5,370                     9,802
         noncontrolling interests




              Net loss attributable to                                 $
              (340,465)                                      $
          (27,266)                              $
          (509,336)        $
          (117,018)
         Intrexon




              Net loss attributable to                                    $
              (2.59)                                        $
          (0.23)                                 $
          (3.93)           $
          (0.98)
         Intrexon per share, basic
         and diluted




              Weighted average shares                                            131,532,851                                            120,763,034                                     129,521,731               119,998,826
         outstanding, basic and
         diluted

    ---

Intrexon Corporation and Subsidiaries
Reconciliation of GAAP to Non-GAAP Measures
(Unaudited)

Adjusted EBITDA and Adjusted EBITDA per share. To supplement Intrexon's financial information presented in accordance with U.S. generally accepted accounting principles ("GAAP"), Intrexon presents Adjusted EBITDA and Adjusted EBITDA per share. A reconciliation of Adjusted EBITDA to net income or loss attributable to Intrexon under GAAP appears below. Adjusted EBITDA is a non-GAAP financial measure that Intrexon calculates as net income or loss attributable to Intrexon adjusted for income tax expense or benefit, interest expense, depreciation and amortization, stock-based compensation, shares issued as compensation for services, impairment loss, expense for in-process research and development reacquired from former collaborators, bad debt expense, litigation expense, realized and unrealized appreciation or depreciation in the fair value of equity securities and preferred stock, and equity in net loss of affiliates. Adjusted EBITDA and Adjusted EBITDA per share are key metrics for Intrexon's management and Board of Directors for evaluating the Company's financial and operating performance, generating future operating plans and making strategic decisions about the allocation of capital. Intrexon's management and Board of Directors believe that Adjusted EBITDA and Adjusted EBITDA per share are useful to understand the long-term performance of Intrexon's core business and facilitate comparisons of the Company's operating results over multiple reporting periods. Intrexon is providing this information to investors and others to assist them in understanding and evaluating the Company's operating results in a manner similar to how its management and Board of Directors evaluate operating results (except for the impact of the change in deferred revenue related to upfront and milestone payments, which is adjusted in the measures evaluated by management and the Board of Directors as discussed below). While Intrexon believes that its non-GAAP financial measures are useful in evaluating its business, and may be of use to investors, this information should be considered supplemental in nature and not as a substitute for the related financial information prepared in accordance with GAAP. In addition, these non-GAAP financial measures may not be the same as non-GAAP financial measures presented by other companies. Adjusted EBITDA and Adjusted EBITDA per share are not measures of financial performance under GAAP, and are not intended to represent cash flows from operations nor earnings per share under GAAP and should not be used as an alternative to net income or loss as an indicator of operating performance or to represent cash flows from operating, investing or financing activities as a measure of liquidity. Intrexon compensates for the limitations of Adjusted EBITDA and Adjusted EBITDA per share by using them only to supplement the Company's GAAP results to provide a more complete understanding of the factors and trends affecting the Company's business. Adjusted EBITDA and Adjusted EBITDA per share have limitations as an analytical tool and you should not consider them in isolation or as a substitute for analysis of Intrexon's results as reported under GAAP.

In addition to the reasons stated above, which are generally applicable to each of the items Intrexon excludes from its non-GAAP financial measure, Intrexon believes it is appropriate to exclude certain items from the definition of Adjusted EBITDA for the following reasons:

    --  Interest expense may be subject to changes in interest rates which are
        beyond Intrexon's control;
    --  Depreciation of Intrexon's property and equipment and amortization of
        acquired identifiable intangibles can be affected by the timing and
        magnitude of business combinations and capital asset purchases;
    --  Stock-based compensation expense is a noncash expense and may vary
        significantly based on the timing, size and nature of awards granted and
        also because the value is determined using formulas which incorporate
        variables, such as market volatility;
    --  Shares issued as compensation for services and bad debt expense are
        noncash expenses which Intrexon excludes in evaluating its financial and
        operating performance;
    --  Impairment loss is a noncash expense which represents the write down of
        the book value of acquired goodwill and intangible assets when fair
        value is determined to be less than book value. These charges are
        nonrecurring and may vary significantly based on economic, regulatory,
        political and other circumstances;
    --  Expense for in-process research and development reacquired from former
        collaborators is a noncash expense which is expected to be an infrequent
        item and may vary significantly based on the scope of the repurchased
        rights;
    --  Unrealized and realized appreciation or depreciation in the fair value
        of securities which Intrexon holds in its collaborators may be
        significantly impacted by market volatility and other factors which are
        outside of the Company's control in the short term and Intrexon intends
        to hold these securities over the long term, except as otherwise
        disclosed; and
    --  Equity in net loss of affiliate reflects Intrexon's proportionate share
        of the income or loss of entities over which the Company has significant
        influence, but not control, and accounts for using the equity method of
        accounting. Intrexon believes excluding the impact of such losses or
        gains on these types of strategic investments from its operating results
        is important to facilitate comparisons between periods.

The following table presents a reconciliation of net loss attributable to Intrexon to EBITDA and also to Adjusted EBITDA, as well as the calculation of Adjusted EBITDA per share, for each of the periods indicated:




                                               
     
            Three months ended                                            Year ended


                                                                                                December 
             31,                                                    December
     31,


                                                               2018                                                2017                          2018                2017



                                                                             
     
     (In thousands)




             Net loss attributable to            $
          (340,465)                                  $
           (27,266)             $
         (509,336)   $
         (117,018)
        Intrexon



             Interest expense                                4,277                                                  95                         8,473                 546



             Income tax benefit                            (1,993)                                              (716)                     (21,528)            (2,880)



             Depreciation and                                7,680                                               8,139                        32,220              30,641
        amortization






             EBITDA                              $
          (330,501)                                  $
           (19,748)             $
         (490,171)    $
         (88,711)



             Stock-based compensation                        7,923                                               9,612                        36,169              41,525



             Shares issued as payment for                    2,291                                               2,678                        10,695              11,118
        services



             Impairment loss                                60,504                                              11,326                        60,504              11,326



             Expense for in-process                        228,027                                                                          236,748
        research and development
        reacquired from former
        collaborators



             Bad debt expense                                  182                                                 124                         1,779               1,217



             Unrealized and realized                         2,635                                               6,654                        30,200             (2,586)
        (appreciation) depreciation
        in fair value of equity
        securities and preferred
        stock, net



             Equity in net loss of affiliates                1,728                                               3,010                        11,608              14,283






             Adjusted EBITDA                      $
          (27,211)                                    $
           13,656              $
         (102,468)    $
         (11,828)

    ---




             Weighted average shares                   131,532,851                                         120,763,034                   129,521,731         119,998,826
        outstanding, basic



             Weighted average shares                   131,532,851                                         121,139,803                   129,521,731         119,998,826
        outstanding, diluted



             Adjusted EBITDA per share,             $
          (0.21)                                      $
           0.11                 $
         (0.79)      $
         (0.10)
        basic



             Adjusted EBITDA per share,             $
          (0.21)                                      $
           0.11                 $
         (0.79)      $
         (0.10)
        diluted

    ---

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SOURCE Intrexon Corporation