World Endometriosis Markets, 2014-2019 & 2019-2026: Key Pipeline and Marketed Drugs, Clinical Trials, Upcoming and Regulatory Events, Patent Information, Licensing and Acquisition Deals
DUBLIN, June 19, 2019 /PRNewswire/ -- The "Market Spotlight: Endometriosis" report has been added to ResearchAndMarkets.com's offering.
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This Market Spotlight report covers the Endometriosis market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts
Key Takeaways
-- The report estimates that in 2017, there were 188.7 million prevalent
cases of endometriosis in women aged 15-49 years worldwide, and
forecasts that number to increase to 199.1 million prevalent cases by
2026.
-- Endometriosis affects an estimated one in 10 women in the reproductive
age group of 15-49 years. The approved drugs in the endometriosis space
target the gonadotropin-releasing hormone receptor, progesterone
receptor, follicle-stimulating hormone, and androgen receptors. The
majority of marketed drugs are administered via the subcutaneous route,
while oral and intramuscular formulations are also available.
-- The majority of industry-sponsored drugs in active clinical development
for endometriosis are in Phase II, with one drug each in Phase I and
Phase III.
-- Therapies in mid-to-late-stage development for endometriosis focus on
targets such as the gonadotropin-releasing hormone receptor,
progesterone receptor, luteinizing hormone receptor, androgen receptors,
and follicle-stimulating hormone. The majority of pipeline drugs in
mid-to-late-stage development for endometriosis are administered via the
oral route, with only one product being tested as a topical formulation.
-- High-impact upcoming events in the endometriosis space comprise topline
Phase III trial results for Relugolix. The overall likelihood of
approval of a Phase I gynecology asset is 13.1%, and the average
probability a drug advances from Phase III is 62.5%. Drugs, on average,
take 11.1 years from Phase I to approval, compared to 12.0 years in the
overall obstetrics/gynecology space.
-- There have been 12 licensing and asset acquisition deals involving
endometriosis drugs during 2014-19. The largest deal was in 2017, when
AstraZeneca obtained commercialization rights to Zoladex in the US and
Canada from TerSera Therapeutics for $320m.
-- The distribution of clinical trials across Phase I-IV indicates that the
majority of trials for endometriosis have been in the early and
mid-phases of development, with 75% of trials in Phase I-II, and only
25% in Phase III-IV.
-- The US has a substantial lead in the number of endometriosis clinical
trials globally. Germany leads the major EU markets, while Japan has the
top spot in Asia.
-- Clinical trial activity in the endometriosis space is dominated by
completed trials. Bayer has the highest number of completed clinical
trials for endometriosis, with 34 trials.
-- Bayer leads industry sponsors with the highest number of clinical trials
for endometriosis, followed by Takeda.
Key Topics Covered:
OVERVIEW
KEY TAKEAWAYS
DISEASE BACKGROUND
TREATMENT
GnRH analogs
Progestins
Combined oral contraceptives
Non-steroidal anti-inflammatory drugs
Danocrine
Surgery
EPIDEMIOLOGY
MARKETED DRUGS
PIPELINE DRUGS
RECENT EVENTS AND ANALYST OPINION
OBE2109 for Endometriosis (June 18, 2018)
Proellex (Oral) for Endometriosis (July 17, 2017)
KEY UPCOMING EVENTS
KEY REGULATORY EVENTS
AbbVie And Neurocrine Biosciences' Elagolix For Endometriosis
PROBABILITY OF SUCCESS
LICENSING AND ASSET ACQUISITION DEALS
PARENT PATENTS
REVENUE OPPORTUNITY
CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase
BIBLIOGRAPHY
Prescription information
APPENDIX
For more information about this report visit https://www.researchandmarkets.com/r/1wupjj
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