Vaccines & Drugs - Revised Market Projections to 2025 due to COVID-19

DUBLIN, May 27, 2020 /PRNewswire/ -- The "COVID-19 Impact on Vaccines & Drugs Market - Global Forecast to 2025" report has been added to's offering.

The global COVID-19 vaccines market is projected to reach USD 1,401 million by 2025 from USD 2,273 million in 2022, at a CAGR of -14.9% during the forecast period. The growth of the global COVID-19 vaccines market is majorly attributed to the increasing number of people infected with COVID-19 and growing funding for vaccine development.

The global COVID-19 drugs market is projected to reach USD 2 million by 2025 from USD 165 million in 2020, at a CAGR of -57.8% during the forecast period. The growth of COVID-19 drugs market is attributed primarily to use of repurposed drugs for compassionate use and the emergence of alternative therapies such as convalescent plasma therapy which were used earlier for treating epidemic diseases such as SARS, MERS, and H1N1.

Furthermore, collaborations between global organizations and governments of various nations to promote the supply of essential drugs and medical supplies will fuel market growth. However, factors such as herd immunity, and uncertainty over the efficacy of vaccines and drugs are expected to hinder the market growth.

Currently, the R&D landscape for COVID-19 vaccines includes 115 vaccine candidates. The most advanced candidates that have recently moved into clinical development are:

    --  mRNA-1273 from Moderna
    --  Ad5-nCoV from CanSino Biologics
    --  INO-4800 from Inovio
    --  LV-SMENP-DC and pathogen-specific aAPC from Shenzhen Geno-Immune Medical

Funding from global governments and foundations is promoting the growth of the market

Incentives are needed to engage manufacturers for the large-scale capacity to guarantee sufficient production of SARS-CoV-2 vaccines. In line with this, various global organizations have come forward to expedite the process, such as Gavi, CEPI, and WHO. However, considering the pandemic scenario of COVID-19, much stronger initiatives are required.

In April 2020, the Bill and Melinda Gates Foundation plans to help fund factories for seven promising vaccines, even before seeing conclusive data. The foundation aims to help scale up manufacturing during testing, rather than after the vaccines have passed the trials.

Besides the most promising Moderna program, several other big pharma companies are involved in COVID-19 vaccine work. Johnson & Johnson has pledged a manufacturing scale-up to 1 billion doses for its federally partnered program. Meanwhile, Sanofi has two partnerships underway - one with the federal government and another with Translate Bio.

Vaccine manufacturing ramp-up to drive the growth further

While global drug makers are pouring massive resources into developing targeted therapies and vaccines, contract development and manufacturing organizations (CDMOs) are finding ways to ramp up the production of vaccines. In line with this, a new CDMO from Belgium's Univercells is offering its expertise to help drug makers scale up their manufacturing.

Pfizer and BioNTech have laid out plans for manufacturing their candidates for trials and producing millions of doses if trials succeed. The companies expect to have millions of doses of a COVID-19 vaccine ready to go by year-end if the companies begin human testing as planned by late April. Pfizer and BioNTech are hoping to advance multiple mRNA vaccine candidates.

Currently, around 155 molecules are under clinical investigation, and approximately 45 molecules are under preclinical development to be targeted against COVID-19. In this list, four promising drugs have been repurposed for use against COVID-19.

    --  Remdesivir
    --  Chloroquine and hydroxychloroquine
    --  Lopinavir and ritonavir (and that same combination plus interferon-beta)
    --  An immune system messenger that can help stop the multiplication of

Researchers and physicians in several countries are focusing on various other existing drugs to examine their potential to treat COVID-19. Chinese authorities, which have been dealing with the virus longer, are recommending Arbidol (umifenovir), which has not been approved in Western countries, as well as old antivirals ribavirin and interferon-alpha. Similarly, Avigan (favipiravir) by Fujifilm has shown promise in the treatment of COVID-19.

As the maximum number of molecules are repurposed drugs that are already approved for other infections and inflammatory diseases, higher stages of development (namely phase 2 trials) hold the largest share. China, along with other Asian countries, holds the largest share of the number of clinical trials being conducted, followed by Europe and the US. Small molecules hold the largest share, followed by monoclonal antibodies and plasma and cell therapy.

AI-powered technologies are making the drug discovery process more efficient and substantially improve success rates at the early stages of drug development. Artificial intelligence algorithms ingest and analyze a vast amount of information and can identify potential drug candidates in lesser time. Such factors will expedite the drug development process.

Some of the major players in the COVID-19 vaccines market include Pfizer Inc. (US), Johnson & Johnson Services, Inc (US), GlaxoSmithKline plc. (UK), Sanofi (France) Serum Institute of India (India), among others. Major players in the COVID-19 drugs market include Gilead Sciences, Inc. (US), Sanofi (France), F. Hoffmann-La Roche Ltd (Switzerland), Merck KGaA (Germany), and Janssen Pharmaceuticals, Inc. (Belgium), among others.

Research Coverage

    --  This report describes and studies the global COVID-19 vaccines and drugs
        market, current pipeline of vaccines and drugs by phase by companies,
        competitive landscape, a viewpoint on COVID-19 pipeline, the impact of
        COVID-19 on other vaccines and drugs in the portfolio/other under
        development vaccines and drugs, macroeconomic indicators (drivers,
        restraints, new opportunities), post-COVID-19 approval scenario,
        challenges in approval/production/supply, strategies to overcome
        challenges, historical examples (SARS, MERS, Ebola, H1N1), new
        strategies, strategies to ramp up production at pandemic level,
        historical examples, and new strategies.

This report provides insights into the following pointers:

    --  Market Penetration: Comprehensive information on the developmental
        pipeline of the top players in the COVID-19 vaccines and drugs market.
        The report analyzes the current pipeline of vaccines and drugs by phase
        by companies, competitive landscape, a viewpoint on COVID-19 pipeline,
        the impact of COVID-19 on other vaccines, and drugs in the
        portfolio/other under development vaccines and drugs and regional
    --  Product Development/Innovation: Detailed insights on upcoming vaccines
        and drugs based on innovative technologies, research and development
        activities, and product launches in the COVID-19 vaccines and drugs
    --  Market Development: Comprehensive information about lucrative markets.
        The report analyzes the markets for vaccines and drugs across regions.
    --  Market Diversification: Exhaustive information about developmental
        products, recent developments, and investments in the COVID-19 vaccines
        and drugs market.
    --  Competitive Assessment: In-depth assessment of strategies, products,
        distribution networks, and manufacturing capabilities of the leading
        players in the COVID-19 vaccines and drugs market.

Key Topics Covered

1 Introduction
1.1 COVID-19 Health Assessment
1.2 COVID-19 Economic Assessment
1.3 COVID-19 Impact on the Economy - Scenario Assessment

2 COVID-19: Development of Vaccines
2.1 Vaccines
2.1.1 Current Pipeline of Vaccines
2.1.2 Competitive Landscape (Top Players Developing Vaccines) Viewpoint on the COVID-19 Pipeline
2.1.3 Macroeconomic Indicators Drivers Increasing Prevalence of Infectious Diseases Growing Funding for Vaccine Development Restraints High Cost of Vaccine Development Drugs and Alternate Therapies Under Development Compassionate Use Immunization Strategies New Opportunities Collaborations Among Global Organizations and Vaccine Manufacturers Challenges Herd Immunity
2.1.4 Post-COVID-19 Vaccine Approval Scenario Challenges in Vaccine Approval/Production/Supply Are Companies Taking Enough Advantage of Artificial Intelligence (AI) to Fast Track Vaccine/Drug Approval? (Medium Criticality) Can Production for Pandemics be a Challenge? (High Criticality) The World Needs a Vaccine But Who Needs it the Most? (Medium Criticality) Global Organizations Are Expediting Clinical Research, But Will Site and Logistical Challenges Cause Delays? (High Criticality) Strategies to Overcome Challenges Collaborations Among Global Organizations Establishing Reliable Supply Chains Historic Examples (Sars, Mers, Ebola, and H1N1) Supply and Demand Issues During H1N1 Vaccination Challenges in Supply Projections Recommendations From the H1N1 Vaccination Program Strategies Adopted by Several Pharmaceutical Companies to Combat the H1N1 Pandemic Historic Examples New Strategies COVID-19 Vaccines Market (Optimistic, Pessimistic, and Realistic) Market Size Estimation for Optimistic Scenario Market Size Estimation for Realistic Scenario Market Size Estimation for Pessimistic Scenario

3 COVID-19: Development of Therapeutic Drugs
3.1 Competitive Landscape (Drugs Market)
3.1.1 Top Players Involved in the Development of Drugs for COVID-19 Sanofi and Regeneron Pharmaceuticals Oncoimmune Gilead Science Sanofi and the National Institute of Respiratory Diseases (Mexico) Roche Cytodyn Merck Kgaa Janssen Pharmaceuticals Masterlek Fujifilm Ridgeback Biotherapeutics L.P. Abbvie Viewpoint on COVID-19 Therapeutic Drug Pipeline Impact of COVID-19 on Other Products in the Portfolio/Other Under-Development Products
3.1.2 Macroeconomic Indicators Drivers Alternate Therapies Targeting COVID-19 Adoption of Organ-On-Chip Models in the Development of Drugs Targeting COVID-19 Compassionate Use Collaborations and Other Developments Promoting COVID-19 Drugs Restraints Herd Immunity and New Vaccines Under Development Uncertainty in the Efficacy and Side Effects of Repurposed Malaria Drugs Targeting COVID-19 New Opportunities Adoption of New Tools to Expedite Drug Discovery Investments in Real-World Evidence by Pharmaceutical Companies Trends Changes in IPR to Promote the Supply of Essential Drugs and Medical Supplies
3.1.3 Post COVID-19 Drug Approval Scenario Challenges in Drug Approval/Production/Supply in the Case of Treatments Being Available for COVID-19, Will They be Available to the People in Need? (High Criticality) Orphan Drug Status, Market Exclusivity - Boon Or Bane? (Medium Criticality) The World Needs Drugs Targeting COVID-19. But Who Needs it the Most (High Criticality) Strategies to Overcome Challenges Production Turbocharge of COVID-19 Hopeful Drugs Accelerated Approvals Drug Manufacturers Initiating Programs to Increase the Market Access of COVID-19 Drugs Historic Examples (Sars, Mers, Ebola, and H1N1) New Strategies Strategies to Ramp Up Production At Pandemic Level Establishing Stable Supply Chains to Ramp Up Production of Drugs Creating External Manufacturing Networks
3.1.4 COVID-19 Drugs Market Estimation Epidemiology Model (Assumption Basis) COVID-19 Drugs Market (Optimistic, Realistic, & Pessimistic Scenarios) Market Size Estimation for Optimistic Scenario Market Size Estimation for Realistic Scenario Market Size Estimation for Pessimistic Scenario

Companies Mentioned

    --  Abbvie
    --  Cytodyn
    --  F. Hoffmann-La Roche Ltd.
    --  Fujifilm
    --  Gilead Sciences Inc.
    --  GlaxoSmithKline plc
    --  Janssen Pharmaceuticals Inc.
    --  Johnson & Johnson Services Inc.
    --  Masterlek
    --  Merck KGaA
    --  Oncoimmune
    --  Pfizer Inc.
    --  Regeneron Pharmaceuticals
    --  Ridgeback Biotherapeutics L.P.
    --  Roche
    --  Sanofi
    --  The National Institute of Respiratory Diseases (Mexico)

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