Molecular Devices unveils next-generation imaging system with deep learning technology

SAN JOSE, Calif., Jan. 25, 2021 /PRNewswire-PRWeb/ -- Molecular Devices, LLC., a leading provider of high-performance life science technology, has globally launched its next-generation, high-content imaging system. Built on the success of the company's flagship model, the ImageXpress® Confocal High-Content Imaging System is designed to help researchers advance phenotypic screening of 3D organoid models. The new system offers faster image acquisition and multiplexing flexibility with high-performance lasers. Image analysis with machine learning will enable researchers to quickly uncover new insights that are provable and repeatable with clear, accurate data.

"As a trusted partner to scientists for over 35 years, Molecular Devices relentlessly innovates high-content imaging and analysis technology that simplifies complex biological research leading to faster, more reliable scientific discoveries," said Susan Murphy, President of Molecular Devices. "The ImageXpress Confocal system with self-learning image analysis software follows a long history of life science solutions that empower our customers to solve their most challenging research questions with the utmost confidence."


The ImageXpress Confocal system offers up to double the throughput speed for 3D organoids and spheroids while helping the scientific community overcome roadblocks when working with complex cell models. Notably:

    --  Increased multiplexing flexibility due to high-performance laser
        excitation with seven laser lines and eight filter combinations.
    --  More accurate and reproducible image analysis enabled by new dual micro
        lens spinning disk confocal technology with enhanced field uniformity.
    --  Greater image resolution and sensitivity with up to 4X increase in
        signal leading to lower exposure times with automated water immersion
        objective technology.
    --  Improved accuracy and robustness of high-content image analysis with
        machine learning through IN Carta(TM) Image Analysis Software.
        Integrated from Cytiva - formerly part of GE Healthcare Life Sciences
        and now a Danaher company - the software has an intuitive guided
        workflow in a modern user interface, and uncovers data insights that
        other technologies miss.


Turning high-content images into actionable insights is a complex process. Relying on traditional analysis methods can lead to errors or oversimplifications that can skew results and diminish assay reliability. IN Carta software paired with the ImageXpress Confocal system uses machine learning to easily convert data-rich image information into repeatable results, while reducing the burden on researchers.

Two key components of IN Carta software that leverage machine learning are the software modules SINAP and Phenoglyphs. SINAP uses deep learning to detect objects of interest to improve accuracy and reliability in the first step of image analysis. Phenoglyphs takes hundreds of image descriptors extracted by SINAP and creates an optimal set of rules for grouping objects with a similar visual appearance. Both modules utilize unsupervised decisions to generate an initial result that is iteratively optimized though user input. Together, they improve the integrity and accuracy of findings through an easy-to-use, end-to-end workflow.


Molecular Devices will feature the ImageXpress Confocal system with IN Carta software in the "Product Showcase" section of the company's virtual booth during the SLAS 2021 online tradeshow. Through video chat, attendees will also have the opportunity to interact one-on-one with product experts and applications scientists, discussing ways to maximize research efforts with the company's advanced life science solutions.

Additional supporting resources will include the video presentation, "Capturing complexity of 3D biology: New advantages of high-content imaging," scheduled for Wednesday, January 27, at 5 p.m. EST, as well as the following ePosters:

    --  Using laser light source for high-content automated imaging to improve
        sensitivity, speed, and precision for complex biological assays
    --  High-content imaging of 3D lung organoids as an assay model for in vitro
        assessment of morphology and toxicity effects
    --  Simplified workflow for phenotypic profiling based on the cell painting

To learn more about ImageXpress Confocal system with IN Carta software, visit

About Molecular Devices, LLC.
Molecular Devices is one of the world's leading providers of high-performance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. Molecular Devices is committed to the continual development of innovative solutions for life science applications. The company is headquartered in Silicon Valley, California with offices around the globe.

To learn more about Molecular Devices' suite of imaging solutions and the role they play in advancing scientific discovery, visit

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Amy Smith, Molecular Devices, +1 408-747-3551,

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SOURCE Molecular Devices