Myeloid Therapeutics to Showcase In Vivo CAR Data and its Diverse mRNA Platform at AACR

    --  Presented data support the ongoing clinical assessment of MT-302, the
        world's first in vivo mRNA CAR drug development candidate
    --  Additional updates highlight Myeloid's pioneering work, including a set
        of novel mRNA CAR constructs for in vivo programming of additional
        immune cell subsets, including NK and T cells

CAMBRIDGE, Mass., April 4, 2024 /PRNewswire/ -- Myeloid Therapeutics, Inc. ("Myeloid"), a clinical stage biotechnology company advancing RNA immunotherapies to conquer cancer, announced that it will provide a preclinical update for MT-302, its novel TROP2-targeting RNA CAR at the 2024 American Association for Cancer Research (AACR) Annual Meeting. MT-302 is currently in a Phase 1 study to assess the therapy's safety and activity in patients with advanced or metastatic epithelial tumors. This advancing study represents the first human trial of any in vivo chimeric antigen receptor (CAR) therapy. Myeloid will also share information on its portfolio of immune cell programming CARs.

"We are thrilled to continue driving this first in vivo mRNA CAR program forward," said Chief Executive Officer Daniel Getts, Ph.D. "Myeloid is at the forefront of in vivo immune cell programming. Programming myeloid cells with MT-302 provides significant potential advantages over TROP2-ADCs, in part because MT-302 modified cells can orchestrate a full immune response." Dr. Getts continued, "We are also showcasing the basis for an extensive CAR portfolio, extending in vivo programming to a diverse range of immune cell subsets such as NK and T cells. These data underscore the versatility and broad potential of our RNA immunotherapies in revolutionizing cancer treatment."

The posters presented at AACR underlie Myeloid's strategic vision, that LNP-delivered mRNA CARs can selectively activate targeted immune cells, thus offering cancer patients the potential future opportunity of cell therapy-like outcomes without the need for ex vivo autologous cell handling or allogeneic cell engineering and manufacturing.

Poster presentation details and abstract highlights include:

Date & Time: Monday, April 8, 2024, 9:00 AM - 12:30 PM PT

Title: In vivo Immune Cell Programming Using mRNA-LNP Chimeric Antigen Receptors
Location: Poster Section 2
Session Category: Immunology
Session Title: CAR-NK, NK Engagers, and NK Modulators
Poster Board Number: 4
Published Abstract Number: 1321

    --  Myeloid has designed novel CARs that achieve expression and function in
        targeted immune cell populations. These CARs, by activating innate and
        adaptive immune responses following the in vivo delivery of
        LNP-formulated mRNA encoded CARs, are capable of eliciting anti-tumor
        efficacy against a range of multiple target antigens evaluated.
    --  To date, Myeloid has demonstrated CAR activity in human cells, and
        following systemic mRNA/LNP delivery in mouse and non-human primates.
    --  MT302, an in vivo CAR targeting TROP2+ epithelial malignancies
        (NCT05969041) is undergoing evaluation in a Phase 1 clinical trial,
        designed to assess the candidate's safety and preliminary efficacy.

Title: In vivo Programming of Natural Killer cells and T cells using mRNA delivered Cytotoxic Chimeric Antigen Receptors
Location: Poster Section 2
Session Category: Immunology
Session Title: CAR-NK, NK Engagers, and NK Modulators
Poster Board Number: 2
Published Abstract Number: 1319

    --  Myeloid's portfolio includes a set of novel CARs designed specifically
        to program NK and T cells.  These novel CARs are not active in
        non-immune cells.
    --  The programed NK cells induce cytotoxicity against antigen-expressing
        tumor cells and trigger the release of cytokines and chemokines,
        important factors to a full immune response.
    --  The company further demonstrated that this approach can be used to
        design receptors for selective expression on the surface of T cells
        utilizing CD3?? chain fused with tumor-targeting scFv.

About Myeloid Therapeutics

Myeloid Therapeutics is a clinical stage immunology company, engineering cutting-edge RNA technology to program immune cells to combat cancer and other deadly diseases. Myeloid is headquartered in Cambridge, MA. For additional information, please visit, https://www.myeloidtx.com/ and follow us on LinkedIn and X/Twitter.

To meet with Myeloid leadership at AACR 2024 please email: partnering@myeloidtx.com

Investor Contact
Amy Conrad
Juniper Point
Amy@juniper-point.com

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Ridge Hill Group
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SOURCE Myeloid Therapeutics, Inc.