Dry Age-related Macular Degeneration Seven Major Market to Exhibit Growth at a CAGR of 19.8% by 2034 | DelveInsight
The dynamics of the dry AMD market are anticipated to change in the coming years owing to the improvement in the diagnosis methodologies, rising awareness of the disease, incremental healthcare spending across the world, and the expected launch of emerging therapies during the forecast period.
LAS VEGAS, April 22, 2024 /PRNewswire/ -- DelveInsight's Dry Age-related Macular Degeneration Market Insights report includes a comprehensive understanding of current treatment practices, dry age-related macular degeneration marketed drug, emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
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Key Takeaways from the Dry Age-related Macular Degeneration Market Report
-- According to DelveInsight's analysis, the market size for dry AMD
reached over USD 1.3 billion in 2023 across the 7MM.
-- DelveInsight's analysis reveals that the overall prevalent population of
dry AMD in the 7MM was reported to be over 64 million in 2023.
-- Leading dry age-related macular degeneration companies such as Alkeus
Pharmaceuticals, Belite Bio, Aviceda Therapeutics, Johnson & Johnson
Innovative Medicine, Allegro Ophthalmics, Lineage Cell Therapeutics
(CellCure Neurosciences), Roche, Cognition Therapeutics, Stealth
BioTherapeutics, Evergreen Therapeutics, Annexon Biosciences, NGM
Biopharmaceuticals, AstraZeneca, Alexion Pharmaceuticals, Ionis
Pharmaceuticals, Novartis, Regenerative Patch Technologies, and others
are developing novel dry AMD drugs that can be available in the dry AMD
market in the coming years.
-- Few promising dry AMD therapies in the pipeline include Gildeuretinol
(ALK-001), Tinlarebant (LBS-008), AVD-104, JNJ-1887, Luminate
(risuteganib), OpRegen, CT1812, Elamipretide, EG-301, ANX007, NGM621,
Danicopan (ALXN2040), IONIS-FB-LRx, Iptacopan (LNP023), CPCB-RPE1, and
others.
-- The majority of pipeline candidates for dry AMD target geographic
atrophy, an advanced stage, rather than focusing on the early and
intermediate stages.
-- With just two FDA-approved treatments (SYFOVRE and IZERVAY), dry AMD
represents a significant market potential, accounting for ~90% of all
AMD patients. With a commercial opportunity in the billions, wet AMD
makes up just around 10% of all AMD cases. This indicates that there is
a big potential payoff for any company that can quickly bring a
successful dry AMD treatment to market. Nevertheless, many companies
have entered the fray due to the size of the prospective opportunity.
-- AVD-104 is striving to become the third therapy approved by the FDA for
treating geographic atrophy secondary to AMD.
-- Among cell therapies, OpRegen offers better financial opportunities,
particularly in light of the fact that complement inhibition's effects
have recently received a lot of attention (in terms of safety). An AAV
vector-based gene therapy is also under investigation by Johnson &
Johnson Innovative Medicine, JNJ-81201887 (JNJ-1887), is being assessed
in a phase II clinical study (NCT05811351). Moreover, Novartis recently
discontinued research on GT005 (PPY988), a gene therapy that was being
tested in many clinical trials, including the Phase II EXPLORE study
(NCT04437368), to treat geographic atrophy.
Discover which therapies are expected to grab the major dry AMD market share @ Dry Age-related Macular Degeneration Market Report
Dry Age-related Macular Degeneration Overview
Dry AMD, a prevalent ocular condition affecting individuals aged 50 and above, leads to a decline in central vision clarity due to macular thinning. The macula, essential for sharp vision in the central field, is affected. Typically, dry AMD progresses slowly, often without causing discomfort or noticeable symptoms for years. Symptoms may include difficulty seeing in low light, distorted straight lines, altered color perception, and gradual vision changes. Dry AMD advances through early, intermediate, and advanced stages, the latter also termed "geographic atrophy," which affects the fovea. Diagnosis involves a thorough eye examination by an ophthalmologist or optometrist, identifying characteristic signs like drusen, yellow deposits beneath the retina, and pigmentation alterations.
Dry Age-related Macular Degeneration Epidemiology Segmentation
Among the 7MM, the US accounted for the highest prevalent cases of dry AMD in 2023, with over 21 million cases; these cases are expected to increase during the forecast period.
According to the estimates, in Asian countries, the prevalence of geographic atrophy is low.
It has been reported that the prevalence of late-stage AMD increases with age. In Japan, it is observed that age-specific cases of geographic atrophy were most prevalent in the 85+ years age group, accounting for over 40% of total cases in 2023.
The dry AMD market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
-- Total Prevalent Cases of AMD
-- Stage-specific (Early and Intermediate AMD and Late Stage (nAMD and GA))
Prevalent Cases of AMD
-- Total Prevalent Cases of Geographic Atrophy
-- Total Prevalent Cases of Dry AMD
-- Total Diagnosed Prevalent Cases of Dry AMD
-- Age-specific Cases of Early and Intermediate AMD
-- Age-specific Cases of Geographic Atrophy
-- Geographic Atrophy Cases by Visual Impairment
Dry Age-related Macular Degeneration Treatment Market
The therapeutic landscape of intermediate AMD is devoid of any approved treatment, and to manage this indication, there is a substantial unmet need for therapy to slow its worsening. The current approach revolves around dietary vitamins and supplements. Recommendations for patients affected by intermediate AMD are focused on the correction of risk factors, especially quitting smoking, following a healthy diet, and treating concomitant diseases such as hypertension, obesity, and atherosclerosis. Identifying early biomarkers for AMD progression is crucial for personalized management and timely intervention.
According to the National Eye Institute (2020), individuals with geographic atrophy may find benefits from enhanced lighting, magnification aids, and low-vision tools to aid in reading. Additionally, some patients may opt for an implantable miniature telescope, which is surgically placed in the eye to replace the lens. By enlarging images, this device can assist specific, carefully chosen patients with either near or distant vision. Unlike neovascular AMD (n-AMD), which is characterized by sudden vision loss and often shows improvement in both structure and function after treatment, geographic atrophy progresses slowly and steadily, eventually leading to irreversible vision loss.
Until recently, there were no established treatments available for geographic atrophy. However, in 2023, the FDA approved SYFOVRE in February and IZERVAY in August to retard the advancement of geographic atrophy lesions. Although injections of IZERVAY or SYFOVRE can decelerate the progression of the disease, it is crucial to understand that they cannot reverse its effects or recover lost vision.
To know more about dry AMD treatment guidelines, visit @ Dry Age-related Macular Degeneration Management
Dry Age-related Macular Degeneration Pipeline Therapies and Key Companies
-- Gildeuretinol (ALK-001): Alkeus Pharmaceuticals
-- Tinlarebant (LBS-008): Belite Bio
-- AVD-104: Aviceda Therapeutics
-- JNJ-1887: Johnson & Johnson Innovative Medicine
-- Luminate (risuteganib): Allegro Ophthalmics
-- OpRegen: Lineage Cell Therapeutics (CellCure Neurosciences) and Roche
-- CT1812: Cognition Therapeutics
-- Elamipretide: Stealth BioTherapeutics
-- EG-301: Evergreen Therapeutics
-- ANX007: Annexon Biosciences
-- NGM621: NGM Biopharmaceuticals
-- Danicopan (ALXN2040): AstraZeneca/Alexion Pharmaceuticals
-- IONIS-FB-LRx: Ionis Pharmaceuticals/Roche
-- Iptacopan (LNP023): Novartis
-- CPCB-RPE1: Regenerative Patch Technologies
Learn more about the FDA-approved drugs for dry AMD @ Drugs for Dry Age-related Macular Degeneration Treatment
Dry Age-related Macular Degeneration Market Dynamics
The dynamics of the dry AMD market are expected to change in the coming years. The dry AMD market has a miscellaneous pipeline, including peptide derivatives, antibodies, antisense oligonucleotides, stem cell therapy, and gene therapy, which work on different mechanisms such as C1q, C3, and C5 Inhibitors, cell replacements, HtrA Serine Peptidase 1 inhibitors, and others. This dry AMD market remains untapped, with a large and increasing patient pool.
Furthermore, many potential therapies are being investigated for the treatment of dry AMD, and it is safe to predict that the treatment space will significantly impact the dry AMD market during the forecast period. Moreover, the anticipated introduction of emerging therapies with improved efficacy and a further improvement in the diagnosis rate are expected to drive the growth of the dry AMD market in the 7MM.
As new drugs are expected to receive approval from regulators after 2025-2027, it will be interesting to follow how the landscape of Dry AMD, particularly geographic atrophy, changes. At this point, no medication is now on the cusp of approval and poses an immediate threat to SYFOVRE or IZERVAY.
However several factors may impede the growth of the dry AMD market. There is a lack of validated endpoint which may hamper the advancement of the therapies and to show their clinical benefits; most of the emerging therapies are targeting geographic atrophy, and this might impact the uptake of emerging drugs owing to anticipated intense competition in the same segment, while emerging gene therapies and stem cell therapies for dry AMD may face hurdles in access and reimbursement due to its anticipated high cost.
Moreover, dry AMD treatment poses a significant economic burden and disrupts patients' overall well-being and QOL. Furthermore, the dry AMD market growth may be offset by failures and discontinuation of emerging therapies, and a shortage of healthcare specialists. In addition, the undiagnosed, unreported cases and the unawareness about the disease may also impact the dry AMD market growth.
Dry Age-related Macular Degeneration Market Report
Metrics
Details
Study Period
2020-2034
Coverage
7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
Dry Age-related Macular Degeneration
Market
CAGR 19.8 %
Dry Age-related Macular Degeneration
Market
Size in 2023
USD 1.3 Billion
Key Dry Age-related Macular Degeneration Companies Alkeus Pharmaceuticals, Belite Bio, Aviceda Therapeutics, Johnson & Johnson Innovative Medicine, Allegro Ophthalmics, Lineage Cell
Therapeutics (CellCure Neurosciences), Roche, Cognition Therapeutics, Stealth BioTherapeutics, Evergreen Therapeutics, Annexon
Biosciences, NGM Biopharmaceuticals, AstraZeneca, Alexion Pharmaceuticals, Ionis Pharmaceuticals, Novartis, Regenerative Patch
Technologies,
and others
Key
Pipeline Dry Age-related Macular Gildeuretinol (ALK-001), Tinlarebant (LBS-008), AVD-104, JNJ-1887, Luminate (risuteganib), OpRegen, CT1812, Elamipretide, EG-
Degeneration
Therapies 301, ANX007, NGM621, Danicopan (ALXN2040), IONIS-FB-LRx, Iptacopan (LNP023), CPCB-RPE1
, and others
Scope of the Dry Age-related Macular Degeneration Market Report
-- Therapeutic Assessment: Dry Age-related Macular Degeneration current
marketed and emerging therapies
-- Dry Age-related Macular Degeneration Market Dynamics: Key Market
Forecast Assumptions of Emerging Dry Age-related Macular Degeneration
Drugs and Market Outlook
-- Competitive Intelligence Analysis: SWOT analysis and Market entry
strategies
-- Unmet Needs, KOL's views, Analyst's views, Dry Age-related Macular
Degeneration Market Access and Reimbursement
Discover more about dry AMD drugs in development @ Dry Age-related Macular Degeneration Clinical Trials
Table of Contents
1
KEY INSIGHTS
2
REPORT INTRODUCTION
3
EXECUTIVE SUMMARY OF DRY AMD
4
KEY EVENTS
5
EPIDEMIOLOGY AND MARKET FORECAST METHODOLOGY
6
DRY AMD MARKET OVERVIEW AT A GLANCE
6.1 MARKET SHARE BY THERAPIES (%) DISTRIBUTION OF DRY AMD IN 2024 IN THE 7MM
6.2 MARKET SHARE BY THERAPIES (%) DISTRIBUTION OF DRY AMD IN 2034 IN THE 7MM
7
DISEASE BACKGROUND AND OVERVIEW
7.1
INTRODUCTION
7.1.1
Classification and Clinical Manifestation
7.1.2
Role of Complement in Geographic Atrophy
7.1.3
Signs and Symptoms of AMD
7.1.4
Risk Factors
7.1.5
Pathogenesis
7.1.6
Pathophysiology of AMD
7.2
DIAGNOSIS
7.2.1
Biomarkers for the Progression of Intermediate AMD
7.2.2
Diagnostic Test
7.3
DIAGNOSTIC GUIDELINES
7.3.1
NICE Guidelines
7.3.2
American Academy of Ophthalmology
7.4
TREATMENT
7.4.1
Complement Pathway Inhibitors
7.4.2
Stem Cell Therapy
7.4.3
Gene Therapy
7.4.4
Angiogenesis Inhibitors
7.4.5
AREDS Supplements
7.4.6
Laser Therapy
7.4.7
Photobiomodulation
7.4.8
Antioxidants
7.4.9
Surgical Options
7.5
TREATMENT GUIDELINES
7.5.1
Harvard Ophthalmology
7.5.2
American Academy of Ophthalmology
7.5.3
European Society of Retina Specialists (EURETINA)
7.5.4
NICE Guideline: Management of AMD
8
EPIDEMIOLOGY AND PATIENT POPULATION
8.1
KEY FINDINGS
8.2
ASSUMPTION AND RATIONALE
8.3
TOTAL PREVALENT CASES OF AMD IN THE 7MM
8.4
TOTAL PREVALENT CASES OF DRY AMD IN THE 7MM
8.5
THE UNITED STATES
8.5.1
Total Prevalent Cases of AMD in the United States
8.5.2
Stage-specific Prevalent Cases of AMD in the United States
8.5.3
Total Prevalent Cases of Geographic Atrophy in the United States
8.5.4
Total Prevalent Cases of Dry AMD in the United States
8.5.5
Total Diagnosed Prevalent Cases of Dry AMD in the United States
8.5.6 Age-specific Cases of Early and Intermediate AMD in the United States
8.5.7
Age-specific Cases of Geographic Atrophy in the United States
8.5.8
Geographic Atrophy Cases by Visual Impairment in the US
8.6
EU4 AND THE UK
8.6.1
Total Prevalent Cases of AMD in EU4 and the UK
8.6.2
Stage-specific Prevalent Cases of AMD in EU4 and the UK
8.6.3
Total Prevalent Cases of Geographic Atrophy in EU4 and the UK
8.6.4
Total Prevalent Cases of Dry AMD in EU4 and the UK
8.6.5
Total Diagnosed Prevalent Cases of Dry AMD in EU4 and the UK
8.6.6 Age-specific Cases of Early and Intermediate AMD in EU4 and the UK
8.6.7
Age-specific Cases of Geographic Atrophy in EU4 and the UK
8.6.8
Geographic Atrophy Cases by Visual Impairment in EU4 and the UK
8.7
JAPAN
8.7.1
Total Prevalent Cases of AMD in Japan
8.7.2
Stage-specific Prevalent Cases of AMD in Japan
8.7.3
Total Prevalent Cases of Geographic Atrophy in Japan
8.7.4
Total Prevalent Cases of Dry AMD in Japan
8.7.5
Total Diagnosed Prevalent Cases of Dry AMD in Japan
8.7.6
Age-specific Cases of Early and Intermediate AMD in Japan
8.7.7
Age-specific Cases of Geographic Atrophy in Japan
8.7.8
Geographic Atrophy Cases by Visual Impairment in Japan
9
PATIENT JOURNEY
9.1
DESCRIPTION
10
MARKETED DRUGS
10.1
KEY COMPETITOR
10.2
IZERVAY (AVACINCAPTAD PEGOL): ASTELLAS PHARMA/IVERIC BIO
10.2.1
Product Description
10.2.2
Regulatory Milestones
10.2.3
Other Developmental Activities
10.2.4
Clinical Developmental Activities
10.2.4.1
Clinical Trial Information
10.2.5
Safety and Efficacy
10.2.6
Product Profile
10.3
SYFOVRE (PEGCETACOPLAN): APELLIS PHARMACEUTICALS
10.3.1
Product Description
10.3.2
Regulatory Milestones
10.3.3
Other Developmental Activities
10.3.4
Clinical Developmental Activities
10.3.4.1
Clinical Trial Information
10.3.5
Safety and Efficacy
10.3.6
Product Profile
11
EMERGING DRUGS
11.1
KEY COMPETITORS
11.2
GILDEURETINOL (ALK-001): ALKEUS PHARMACEUTICALS
11.2.1
Product Description
11.2.2
Other Developmental Activities
11.2.3
Clinical Developmental Activities
11.2.3.1
Clinical Trial Information
11.3
TINLAREBANT (LBS-008): BELITE BIO
11.3.1
Product Description
11.3.2
Other Developmental Activities
11.3.3
Clinical Developmental Activities
11.3.3.1
Clinical Trial Information
11.3.4
Safety and Efficacy
11.4
AVD-104: AVICEDA THERAPEUTICS
11.4.1
Product Description
11.4.2
Other Developmental Activities
11.4.3
Clinical Developmental Activities
11.4.3.1
Clinical Trial Information
11.4.4
Safety and Efficacy
11.5
JNJ-1887: JOHNSON & JOHNSON INNOVATIVE MEDICINE
11.5.1
Product Description
11.5.2
Other Developmental Activities
11.5.3
Clinical Developmental Activities
11.5.3.1
Clinical Trial Information
11.5.4
Safety and Efficacy
11.6
LUMINATE (RISUTEGANIB): ALLEGRO OPHTHALMICS
11.6.1
Product Description
11.6.2
Other Developmental Activities
11.6.3
Clinical Developmental Activities
11.6.3.1
Clinical Trial Information
11.6.4
Safety and Efficacy
11.7 OPREGEN: LINEAGE CELL THERAPEUTICS (CELLCURE NEUROSCIENCES) AND ROCHE
11.7.1
Product Description
11.7.2
Other Developmental Activities
11.7.3
Clinical Developmental Activities
11.7.3.1
Clinical Trial Information
11.7.4
Safety and Efficacy
11.8
CT1812: COGNITION THERAPEUTICS
11.8.1
Product Description
11.8.2
Other Developmental Activities
11.8.3
Clinical Developmental Activities
11.8.3.1
Clinical Trial Information
11.9
ELAMIPRETIDE: STEALTH BIOTHERAPEUTICS
11.9.1
Product Description
11.9.2
Other Developmental Activities
11.9.3
Clinical Developmental Activities
11.9.3.1
Clinical Trial Information
11.9.4
Safety and Efficacy
11.1
EG-301: EVERGREEN THERAPEUTICS
11.10.1
Product Description
11.10.2
Clinical Developmental Activity
11.10.2.1
Clinical Trial Information
11.11
ANX007: ANNEXON BIOSCIENCES
11.11.1
Product Description
11.11.2
Other Developmental Activities
11.11.3
Clinical Developmental Activity
11.11.3.1
Clinical Trial Information
11.11.4
Safety and Efficacy
11.12
NGM621: NGM BIOPHARMACEUTICALS
11.12.1
Product Description
11.12.2
Other Developmental Activities
11.12.3
Clinical Developmental Activities
11.12.3.1
Clinical Trial Information
11.12.4
Safety and Efficacy
11.13
DANICOPAN (ALXN2040): ASTRAZENECA/ALEXION PHARMACEUTICALS
11.13.1
Product Description
11.13.2
Other Developmental Activity
11.13.3
Clinical Developmental Activity
11.13.3.1
Clinical Trial Information
11.14
IONIS-FB-LRX: IONIS PHARMACEUTICALS/ROCHE
11.14.1
Product Description
11.14.2
Other Developmental Activity
11.14.3
Clinical Developmental Activity
11.14.3.1
Clinical Trial Information
11.14.4
Safety and Efficacy
11.15
IPTACOPAN (LNP023): NOVARTIS
11.15.1
Product Description
11.15.2
Clinical Development
11.15.2.1
Clinical Trial Information
11.16
CPCB-RPE1: REGENERATIVE PATCH TECHNOLOGIES
11.16.1
Product Description
11.16.2
Other Developmental Activities
11.16.3
Clinical Developmental Activities
11.16.3.1
Clinical Trial Information
11.16.4
Safety and Efficacy
12
DRY AMD: MARKET ANALYSIS
12.1
KEY FINDINGS
12.2
MARKET OUTLOOK
12.3
CONJOINT ANALYSIS
12.4
KEY MARKET FORECAST ASSUMPTIONS
12.5
TOTAL MARKET SIZE OF DRY AMD IN THE 7MM
12.6
UNITED STATES MARKET SIZE
12.6.1
Total Market Size of Dry AMD in the United States
12.6.2
Market Size of Dry AMD by Therapies in the United States
12.7
EU4 AND THE UK MARKET SIZE
12.7.1
Total Market Size of Dry AMD in EU4 and the UK
12.7.2
Market Size of Dry AMD by Therapies in EU4 and the UK
12.8
JAPAN MARKET SIZE
12.8.1
Total Market Size of Dry AMD in Japan
12.8.2
Market Size of Dry AMD by Therapies in Japan
13
UNMET NEEDS
14
SWOT ANALYSIS
15
KOL VIEWS
16
MARKET ACCESS AND REIMBURSEMENT
16.1
UNITED STATES
16.1.1
Centre for Medicare and Medicaid Services (CMS)
16.2
EU4 AND THE UK
16.2.1
Germany
16.2.2
France
16.2.3
Italy
16.2.4
Spain
16.2.5
United Kingdom
16.3
JAPAN
16.3.1
MHLW
16.4
MARKET ACCESS AND REIMBURSEMENT OF DRY AMD
16.4.1
IZERVAY
16.4.2
SYFOVRE
17
APPENDIX
17.1
BIBLIOGRAPHY
17.2
REPORT METHODOLOGY
18
DELVEINSIGHT CAPABILITIES
19
DISCLAIMER
20
ABOUT DELVEINSIGHT
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