JAK Inhibitors Clinical Trial Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Pipeline Comprising 50+ Companies Working in the Domain

JAK inhibitors are a class of medications that work by blocking Janus kinases (JAKs), enzymes that are involved in the signaling pathways of various cytokines and growth factors. JAK inhibitors offer a more targeted approach to treating immune-mediated diseases compared to traditional therapies like corticosteroids or conventional immunosuppressants; this specificity reduces side effects and increases efficacy and is a major driver for the demand for JAK inhibitors.

LAS VEGAS, Oct. 22, 2024 /PRNewswire/ -- DelveInsight's 'JAK Inhibitors Pipeline Insight 2024' report provides comprehensive global coverage of pipeline JAK inhibitors in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the JAK inhibitors pipeline domain.

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Key Takeaways from the JAK Inhibitors Pipeline Report

    --  DelveInsight's JAK inhibitors pipeline report depicts a robust space
        with 50+ active players working to develop 55+ pipeline JAK inhibitors.
    --  Key JAK inhibitors companies such as Incyte Corporation, Celon Pharma,
        Aclaris Therapeutics, Sareum, AstraZeneca, Incyte Corporation, Ajax
        Therapeutics, Pfizer, GSK, Dizal Pharmaceutical, Confluence Life
        Sciences, Celon Pharma, Incyte Corporation, Arcutis
        Biotherapeutics/Reistone Biopharma, Esker Therapeutics, Bristol-Myers
        Squibb, Chia Tai Tianqing Pharmaceutical and others are evaluating new
        JAK Inhibitors drugs to improve the treatment landscape.
    --  Promising pipeline JAK inhibitors such as Povorcitinib, CPL409116,
        ATI-2138, SDC 1802, AZD 4604, INCB-160058, Research programme: JAK2
        inhibitors, Ritlecitinib, Momelotinib, DZD4205, ATI 2138, CPL 409116,
        Itacitinib, Ivarmacitinib, ESK 001, Repotrectinib, Rovadicitinib, and
        others are under different phases of JAK inhibitors clinical trials.
    --  In October 2024, Pelabresib in combination with ruxolitinib showed
        benefit in treating patients with JAK Inhibitor-Naïve Myelofibrosis
        significantly reduced splenomegaly, and improved anemia that has not
        been previously treated with Janus kinase inhibitors (JAKis).
    --  In September 2024, Eli Lilly and Company and EVA Pharma announced that
        the companies have agreed to expand access to baricitinib to an
        estimated 20,000 people in 49 low- to middle-income countries in Africa
        by 2030.
    --  In May 2024, Ajax Therapeutics, Inc., announced that it had received
        clearance for its Investigational New Drug application from the U.S.
        Food and Drug Administration (FDA) to initiate a Phase I clinical study
        of AJ1-11095, a first-in-class Type II JAK2 inhibitor, for the treatment
        of patients with myelofibrosis.
    --  In February 2024, Novartis announced that it intends to acquire
        MorphoSys. The acquisition, which was unanimously approved by the boards
        of both Novartis and MorphoSys, is expected to close in the first half
        of 2024, subject to customary closing conditions.
    --  In January 2024, NS Pharma received orphan drug designation (ODD) from
        the European Commission (EC) for NS-229, which is being developed to
        treat eosinophilic granulomatosis with polyangiitis (EGPA), a rare
        autoimmune disease.
    --  In December 2023, Sun Pharmaceuticals Inc. announced that it has entered
        a licensing agreement with Aclaris Therapeutics Inc., the company
        announced in a regulatory filing. Under the agreement, Aclaris granted
        Sun Pharma exclusive rights under certain patents for the use of
        deuruxolitinib, Sun Pharma's JAK inhibitor, or other isotopic forms of
        ruxolitinib, to treat alopecia areata (AA) or androgenetic alopecia
        (AGA).

Request a sample and discover the recent advances in JAK inhibitors drugs @ JAK Inhibitors Pipeline Report

The JAK inhibitors pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage JAK inhibitors drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the JAK inhibitors clinical trial landscape.

JAK Inhibitors Overview

Janus kinase (JAK) inhibitors are a class of medications designed to interfere with the activity of the Janus kinase family of enzymes, which play a crucial role in the signaling pathways of immune responses. These enzymes are key mediators in transmitting signals from cytokines and growth factors, which regulate blood cell production and immune system function. By blocking these signals, JAK inhibitors help to control the overactive immune response seen in several inflammatory and autoimmune diseases. They have shown significant efficacy in treating conditions like rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, among others. The most common JAK inhibitors include tofacitinib, baricitinib, and upadacitinib, which are administered orally.

Beyond their role in autoimmune diseases, JAK inhibitors are also being explored for use in treating certain cancers and myeloproliferative disorders, where abnormal JAK signaling contributes to uncontrolled cell growth. In diseases like myelofibrosis and polycythemia vera, JAK inhibitors can help reduce symptoms and improve quality of life. However, there are potential side effects associated with their use, including increased susceptibility to infections, blood clots, and cardiovascular risks, given their impact on the immune system. As research continues, the therapeutic potential of JAK inhibitors is expanding, offering new hope for patients with difficult-to-treat conditions.

Find out more about JAK inhibitors drugs @ JAK Inhibitors Analysis

A snapshot of the Pipeline JAK Inhibitors Drugs mentioned in the report:


                Drugs              Company            Phase 
     
              Indication                          RoA


     Povorcitinib       Incyte Corporation Phase III          Hidradenitis suppurativa; Vitiligo        Oral


     Ritlecitinib     
     Pfizer             Phase III        
     Ulcerative colitis; Vitiligo              Oral


     CPL409116          Celon Pharma       Phase II         
     Rheumatoid arthritis                      Oral


     ATI-2138           Aclaris
                         Therapeutics      Phase II         
     Atopic dermatitis                         Oral


     Golidocitinib      Dizal
                         Pharmaceutical    Phase II         
     Non-small cell lung cancer                Oral


     AJ1-11095,         Ajax Therapeutics,
                         Inc.              Phase I          
     Primary Myelofibrosis                     Oral


     SDC 1802         
     Sareum             Preclinical        Precursor T-cell lymphoblastic leukaemia-
                                                               lymphoma                                 Oral

Learn more about the emerging JAK inhibitors @ JAK Inhibitors Clinical Trials

JAK Inhibitors Therapeutics Assessment

The JAK inhibitors pipeline report proffers an integral view of the emerging JAK inhibitors segmented by stage, product type, molecule type, and route of administration.

Scope of the JAK Inhibitors Pipeline Report

    --  Coverage: Global
    --  Therapeutic Assessment By Product Type: Mono, Combination,
        Mono/Combination
    --  Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical,
        Phase I, Phase II, Phase III
    --  Therapeutics Assessment By Route of Administration: Oral, Intravenous,
        Subcutaneous, Parenteral, Topical
    --  Therapeutics Assessment By Molecule Type: Recombinant fusion proteins,
        Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
    --  Key JAK Inhibitors Companies: Incyte Corporation, Celon Pharma, Aclaris
        Therapeutics, Sareum, AstraZeneca, Incyte Corporation, Ajax
        Therapeutics, Pfizer, GSK, Dizal Pharmaceutical, Confluence Life
        Sciences, Celon Pharma, Incyte Corporation, Arcutis
        Biotherapeutics/Reistone Biopharma, Esker Therapeutics, Bristol-Myers
        Squibb, Chia Tai Tianqing Pharmaceutical, and others.
    --  Key JAK Inhibitors Pipeline Therapies: Povorcitinib, CPL409116,
        ATI-2138, SDC 1802, AZD 4604, INCB-160058, Research programme: JAK2
        inhibitors, Ritlecitinib, Momelotinib, DZD4205, ATI 2138, CPL 409116,
        Itacitinib, Ivarmacitinib, ESK 001, Repotrectinib, Rovadicitinib, and
        others.

Dive deep into rich insights for new JAK inhibitors, visit @ JAK Inhibitors Drugs

Table of Contents



     1.  
     JAK Inhibitors Pipeline Report Introduction



     2.    JAK Inhibitors Pipeline Report Executive Summary



     3.  
     JAK Inhibitors Pipeline: Overview



     4.    Analytical Perspective In-depth Commercial Assessment



     5.  
     JAK Inhibitors Clinical Trial Therapeutics



     6.    JAK Inhibitors Pipeline: Late-Stage Products (Pre-
             registration)



     7.    JAK Inhibitors Pipeline: Late-Stage Products (Phase
             III)



     8.    JAK Inhibitors Pipeline: Mid-Stage Products (Phase
             II)



     9.    JAK Inhibitors Pipeline: Early-Stage Products (Phase
             I)



     10.   JAK Inhibitors Pipeline Therapeutics Assessment



     11.   Inactive Products in the JAK Inhibitors Pipeline



     12.   Company-University Collaborations (Licensing/
             Partnering) Analysis



     13. 
     Key Companies



     14. 
     Key Products in the JAK Inhibitors Pipeline



     15. 
     Unmet Needs



     16. 
     Market Drivers and Barriers



     17. 
     Future Perspectives and Conclusion



     18. 
     Analyst Views



     19. 
     Appendix

For further information on the JAK inhibitors pipeline therapeutics, reach out @ JAK Inhibitors Therapeutics

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