Follicular Lymphoma Clinical Trial Pipeline Appears Robust With 50+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight
Advances in immunotherapy have ushered in a new era of treatment for follicular lymphoma (FL), particularly for patients who have experienced relapse after conventional chemotherapy regimens. This paradigm shift is characterized by the emergence of innovative therapies like CAR T-cell therapy and bispecific antibodies, which have demonstrated remarkable efficacy in targeting and eradicating lymphoma cells.
CAR T-cell therapy represents a groundbreaking approach where a patient's own T-cells are genetically engineered to recognize and attack cancer cells. This personalized treatment has shown significant promise, especially for individuals who have undergone extensive previous therapies. One notable example is Axicabtagene ciloleucel (Yescarta), a CAR T-cell therapy approved for use in patients with relapsed or refractory follicular lymphoma. Clinical trials have highlighted its ability to induce durable remissions, with some patients experiencing long-term remission even after multiple prior therapies.
LAS VEGAS, Nov. 28, 2024 /PRNewswire/ -- DelveInsight's 'Follicular Lymphoma Pipeline Insight 2024' report provides comprehensive global coverage of pipeline follicular lymphoma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the follicular lymphoma pipeline domain.
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Key Takeaways from the Follicular Lymphoma Pipeline Report
-- DelveInsight's follicular lymphoma pipeline report depicts a robust
space with 50+ active players working to develop 55+ pipeline therapies
for follicular lymphoma treatment.
-- Key follicular lymphoma companies such as Chia Tai Tianqing
Pharmaceutical Group, Incyte Corporation, Mabworks, Johnson & Johnson
Innovative Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck
Sharp & Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics,
Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma,
Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR
Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene,
AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med
Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics,
OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer,
Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma,
Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century
Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH,
Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna
Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar
Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma,
NeoImmuneTech, and others are evaluating new follicular lymphoma drugs
to improve the treatment landscape.
-- Promising follicular lymphoma pipeline therapies such as Parsaclisib,
TQ-B3525, Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat,
Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab
tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314,
GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673,
BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291,
SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111,
Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 +
STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244,
IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219,
ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and
others are under different phases of follicular lymphoma clinical
trials.
-- In August 2024, the company expects to file a supplemental Biologics
License Application for tafasitamab for the treatment of patients with
FL who have failed at least one prior systemic anti-CD20 immunotherapy
or chemo-immunotherapy by the end of 2024 based on the positive Phase
III results.
-- In June 2024, a consortium of Eugene Private Equity and Korea
Development Bank Private Equity announced that they would acquire 80% of
South Korean vaccine maker Boryung Biopharma Co. for 320 billion won
(USD 231 million).
-- In February 2024, Incyte announced that it had entered into an asset
purchase agreement with MorphoSys AG, which gives Incyte exclusive
global rights for tafasitamab. Incyte will now recognize revenue and
cost for all US commercialization and clinical development and MorphoSys
will no longer be eligible to receive future milestone, profit split and
royalty payments.
-- In September 2023, OncoNano Medicine, Inc. announced a clinical trial
supply agreement with Regeneron for the use of Libtayo (cemiplimab), a
PD-1 inhibitor, in the combination stage of the first human trial of
ONM-501, a dual-activating STING (STimulator of INterferon Genes)
agonist and lead therapeutic development candidate. The ONM-501
first-in-human trial is a multicenter Phase Ia/b dose escalation and
dose expansion study of intratumoral ONM-501 as monotherapy and in
combination with Libtayo in patients with advanced solid tumors and
lymphomas. OncoNano is the sponsor of the clinical trial, and Regeneron
will supply cemiplimab.
-- In May 2023, Janssen Pharmaceutical Companies of Johnson & Johnson
announced that it had entered into a worldwide collaboration and license
agreement with Cellular Biomedicine Group Inc. (CBMG) to develop,
manufacture, and commercialize next-generation chimeric antigen receptor
(CAR) T-cell therapies for the treatment of B-cell malignancies. Under
the terms of the agreement, CBMG will grant Janssen a worldwide license
to develop and commercialize the CAR-T assets, except in Greater China.
Janssen and CBMG will negotiate an option for Janssen to commercialize
the products in the Chinese territory. Janssen will make an upfront
payment of USD 245 million that will be accounted for in the second
quarter as a research and development expense. Additional future
payments will be based upon achieving certain development, regulatory,
and sales milestones, as well as tiered royalty payments on worldwide
net trade sales, excluding Greater China.
Request a sample and discover the recent advances in follicular lymphoma treatment drugs @ Follicular Lymphoma Pipeline Report
The follicular lymphoma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage follicular lymphoma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the follicular lymphoma clinical trial landscape.
Follicular Lymphoma Overview
Follicular lymphoma is a common type of non-Hodgkin lymphoma (NHL) that originates from B-cells, a kind of white blood cell responsible for producing antibodies. This cancer is characterized by the growth of abnormal lymphoid follicles, which can disrupt normal lymphatic function. While the exact causes of follicular lymphoma are not fully understood, certain factors may increase the risk, including age (most commonly affecting adults over 60), a family history of lymphoma, and potential environmental factors such as exposure to pesticides or chemicals.
Symptoms of follicular lymphoma can vary widely but may include painless swelling of lymph nodes in the neck, armpit, or groin, unexplained weight loss, night sweats, fatigue, and fever. Some patients may remain asymptomatic for extended periods, as this type of lymphoma can progress slowly. Diagnosis typically involves a combination of physical examinations, blood tests, imaging studies (like CT scans), and a biopsy of affected lymph nodes. The biopsy helps determine the subtype and stage of the lymphoma, which is crucial for planning treatment.
Treatment for follicular lymphoma depends on the stage of the disease and the patient's overall health. Options may include watchful waiting for asymptomatic cases, chemotherapy, immunotherapy (such as monoclonal antibodies), and targeted therapies. In some cases, stem cell transplants may be considered for patients with more aggressive forms or those who do not respond to initial treatments. Given the indolent nature of follicular lymphoma, ongoing management, and regular monitoring are vital for achieving the best possible outcomes.
Find out more about follicular lymphoma treatment drugs @ Drugs for Follicular Lymphoma Treatment
A snapshot of the Follicular Lymphoma Pipeline Drugs mentioned in the report:
Drugs
Company Phase
MoA RoA
TQ-B3525 Chia Tai Tianqing Pre- Phosphatidylinositol 3 kinase delta inhibitors;
Pharmaceutical Group Registration Phosphatidylinositol 3 kinase gamma inhibitors Oral
Tafasitamab
Incyte Corporation Phase III Antibody-dependent cell cytotoxicity; T lymphocyte
stimulants Intravenous
MIL62
Mabworks Phase III
Antibody-dependent cell cytotoxicity Intravenous
Ibrutinib AbbVie/ Johnson & Johnson Phase III Agammaglobulinaemia tyrosine kinase inhibitors; Emt protein-
Innovative Medicine tyrosine kinase inhibitors Oral
AZD0486
AstraZeneca Phase III Antibody-dependent cell cytotoxicity; T lymphocyte
stimulants Intravenous
NKTR-255
Nektar Therapeutics Phase II/ Antibody-dependent cell cytotoxicity; Interleukin 15
III receptor agonists Intravenous
Abexinostat Xynomic Pharmaceuticals Phase II Histone deacetylase inhibitors; Rad51 recombinase inhibitors Oral
Acalabrutinib
AstraZeneca Phase II
Agammaglobulinaemia tyrosine kinase inhibitors Oral
Zilovertamab vedotin
Merck Sharp & Dohme Phase II Receptor tyrosine kinase-like orphan receptor 1 inhibitor Intravenous
SHR2554 Jiangsu HengRui Medicine Co.,
Ltd. Phase II
Enhancer of zeste homolog 2 protein inhibitors Oral
Nivolumab
Bristol-Myers Squibb Phase II Antibody-dependent cell cytotoxicity; Programmed cell death
1 receptor antagonists; T lymphocyte stimulants Intravenous
Loncastuximab tesirine
ADC Therapeutics Phase II
Alkylating agents; DNA cross-linking agents Intravenous
Learn more about the emerging follicular lymphoma pipeline therapies @ Follicular Lymphoma Clinical Trials
Follicular Lymphoma Therapeutics Assessment
The follicular lymphoma pipeline report proffers an integral view of the follicular lymphoma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Follicular Lymphoma Pipeline Report
-- Coverage: Global
-- Therapeutic Assessment By Product Type: Mono, Combination,
Mono/Combination
-- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical,
Phase I, Phase II, Phase III
-- Therapeutics Assessment By Route of Administration: Intra-articular,
Intraocular, Intrathecal, Intravenous, Oral, Parenteral, Subcutaneous,
Topical, Transdermal
-- Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide,
Small molecule
-- Therapeutics Assessment By Mechanism of Action: Phosphatidylinositol 3
kinase delta inhibitors, Phosphatidylinositol 3 kinase gamma inhibitors,
Emt protein-tyrosine kinase inhibitors, Interleukin 15 receptor
agonists, Histone deacetylase inhibitors, Rad51 recombinase inhibitors,
Agammaglobulinaemia tyrosine kinase inhibitors, Apoptosis stimulants,
Cell cycle inhibitors, Tubulin inhibitors, Tubulin polymerisation
inhibitors, Enhancer of zeste homolog 2 protein inhibitors,
Antibody-dependent cell cytotoxicity, Programmed cell death 1 receptor
antagonists, T lymphocyte stimulants, Alkylating agents, DNA
cross-linking agents
-- Key Follicular Lymphoma Companies: Chia Tai Tianqing Pharmaceutical
Group, Incyte Corporation, Mabworks, Johnson & Johnson Innovative
Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck Sharp &
Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics,
Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma,
Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR
Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene,
AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med
Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics,
OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer,
Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma,
Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century
Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH,
Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna
Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar
Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma,
NeoImmuneTech, and others.
-- Key Follicular Lymphoma Pipeline Therapies: Parsaclisib, TQ-B3525,
Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat,
Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab
tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314,
GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673,
BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291,
SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111,
Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 +
STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244,
IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219,
ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and
others.
Dive deep into rich insights for new drugs for follicular lymphoma treatment, visit @ Follicular Lymphoma Drugs
Table of Contents
1. Follicular Lymphoma Pipeline Report Introduction
2. Follicular Lymphoma Pipeline Report Executive Summary
3.
Follicular Lymphoma Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Follicular Lymphoma Clinical Trial Therapeutics
6. Follicular Lymphoma Pipeline: Late-Stage Products
(Pre-registration)
7. Follicular Lymphoma Pipeline: Late-Stage Products
(Phase III)
8. Follicular Lymphoma Pipeline: Mid-Stage Products
(Phase II)
9. Follicular Lymphoma Pipeline: Early-Stage Products
(Phase I)
10. Follicular Lymphoma Pipeline Therapeutics Assessment
11. Inactive Products in the Follicular Lymphoma Pipeline
12. Company-University Collaborations (Licensing/
Partnering) Analysis
13.
Key Companies
14. Key Products in the Follicular Lymphoma Pipeline
15.
Unmet Needs
16.
Market Drivers and Barriers
17.
Future Perspectives and Conclusion
18.
Analyst Views
19.
Appendix
For further information on the follicular lymphoma pipeline therapeutics, reach out @ Follicular Lymphoma Treatment Drugs
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