Ginkgo Bioworks Reports Fourth Quarter and Full Year 2024 Financial Results

Ginkgo provides update on its restructuring process including significant improvement in cash flow in the fourth quarter, completion of site consolidation and an expanded cost savings target

Cell Engineering revenue of $35 million in the fourth quarter of 2024, representing 29% growth over 2023

BOSTON, Feb. 25, 2025 /PRNewswire/ -- Ginkgo Bioworks Holdings, Inc. (NYSE: DNA, "Ginkgo"), which is building the leading platform for cell programming and biosecurity, today announced its results for the fourth quarter and year ended December 31, 2024. The update, including a webcast slide presentation with additional details on the fourth quarter and full year, as well as supplemental financial information will be available at investors.ginkgobioworks.com.

Fourth Quarter 2024 Financial Results

    --  Fourth quarter 2024 Total revenue of $44 million, up from $35 million in
        the comparable prior year period
        --  Fourth quarter 2024 Cell Engineering revenue of $35 million, up from
            $27 million in the comparable prior year period, an increase of 29%
            driven by growth with large biopharma customers
        --  Fourth quarter 2024 Biosecurity revenue of $9 million, up from $8
            million in the comparable prior year period, with gross profit
            margin of 17%
    --  Fourth quarter 2024 GAAP net loss of $(108) million, compared to $(212)
        million in the comparable prior year period
    --  Fourth quarter 2024 Adjusted EBITDA of $(57) million, up from $(101)
        million in the comparable prior year period, driven by the increase in
        revenue as well as a decrease in operating expenses
    --  Cash and cash equivalents balance as of December 31, 2024 of $562
        million. Cash flow of $(55) million in the fourth quarter of 2024, up
        from $(114) million in the third quarter of 2024.

"I'm very proud of the team for pushing the technical envelope and delivering for our customers as we enter this new year," said Jason Kelly, co-founder and CEO of Ginkgo Bioworks. "We made a lot of changes in 2024, but our commitment to our mission is as strong as ever. Our expansions into life science tools with our Datapoints and Automation offerings are going well and we are continuing to drive our cost-cutting and sustainable revenue-generating efforts as we enter a very exciting year for Ginkgo."

Full Year 2024 Financial Highlights

    --  Full year 2024 Total revenue of $227 million, down from $251 million in
        the prior year, a decrease of 10% as Biosecurity revenue transitioned
        from K-12 testing to a more recurring business model. Full year 2024
        also benefited from $45 million of non-cash revenue from a release of
        deferred revenue in the third quarter relating to the mutual termination
        of a customer agreement.
        --  Full year 2024 Cell Engineering revenue of $174 million, up from
            $144 million in the prior year, an increase of 21%. Excluding the
            $45 million non-cash deferred revenue release in the third quarter,
            full year 2024 Cell Engineering revenue of $129 million decreased
            10%, driven by the shift from early stage customers to
            large/enterprise customers along with commercial changes related to
            the restructuring.
        --  Full year 2024 Biosecurity revenue of $53 million, down from $108
            million in the prior year, a decrease of 51%, with full year 2024
            Biosecurity gross profit margin of 27%
    --  Full year 2024 GAAP net loss of $(547) million, compared to $(893)
        million in the prior year
    --  Full year 2024 Adjusted EBITDA of $(293) million, up from $(365) million
        in the prior year

Recent Business Highlights & Strategic Positioning

    --  Cell Engineering closed deals with new and existing customers
        --  Added 31 new programs and other customer contracts to the Cell
            Engineering platform in Q4 2024, of which 14 were comparable in size
            and scope to historically reported New Programs, and an additional
            17 contracts that represent a variety of other deal archetypes, such
            as Datapoints projects
        --  Signed contract for our Antibody Developability product from Ginkgo
            Datapoints with a top biopharma company
        --  Ginkgo Automation was selected to deploy a flexible laboratory
            automation system for cutting-edge biofuels and bioproducts research
            at Great Lakes Bioenergy Research Center ("GLBRC"), and demonstrated
            its technology at the 2025 annual meeting of the Society for
            Laboratory Automation and Screening ("SLAS")
        --  Awarded up to $9.4 million in partnership with Carnegie Mellon
            University to develop implantable cell-based bioelectronic devices
            for disease treatment under ARPA-H's REACT program
    --  Ginkgo Biosecurity continues to work towards creating solutions that
        offer persistent, pervasive monitoring of biothreats
        --  Awarded contract with the European Health and Digital Executive
            Agency ("HaDEA") to deliver next-generation 'agnostic diagnostics'
            for respiratory viruses at the point of care, with Ginkgo and its
            consortium partners eligible to receive up to EUR24 million over the
            next 4 years
    --  Ginkgo made significant progress on its plan to reach Adjusted EBITDA
        breakeven by the end of 2026
        --  Cash flow of $(55) million in the fourth quarter of 2024, up from
            $(114) million in the third quarter of 2024
        --  Ginkgo's reduction in force and other cost cutting measures have
            achieved an annualized run-rate cost reduction of $190 million as of
            the fourth quarter of 2024, with a target to increase that to $250
            million by the end of the third quarter of 2025. Site consolidation
            efforts have also been substantially completed, with excess space
            available for sublease.

Full Year 2025 Guidance

    --  Ginkgo expects Total revenue of $160-$180 million in 2025
        --  Ginkgo expects Cell Engineering revenue of $110-$130 million in
            2025, with potential upside from the recent launch of Tools
            offerings
        --  Ginkgo expects Biosecurity revenue in 2025 of at least $50 million,
            representing approximate current contracted backlog and expected
            program renewal along with key assumption of continued availability
            of government funding, with potential upside from additional
            opportunities in the pipeline

Conference Call Details
Ginkgo will host a videoconference today, Tuesday, February 25, 2025, beginning at 5:30 p.m. ET. The presentation will include an overview of fourth quarter and 2024 full year financial performance, recent business updates, a discussion on Ginkgo's outlook, as well as a moderated question and answer session.

To ask a question ahead of the presentation, please submit your questions to @Ginkgo on X (hashtag #GinkgoResults) or by sending an e-mail to investors@ginkgobioworks.com.

A webcast link is available on Ginkgo's Investor Relations website and a replay will be made available following the presentation.

Ginkgo Investor Website: https://investors.ginkgobioworks.com/events/

Audio-Only Dial Ins:
+1 646 876 9923 (New York)
+1 301 715 8592 (Washington DC)
+1 312 626 6799 (Chicago)
+1 669 900 6833 (San Jose)
+1 253 215 8782 (Tacoma)
+1 346 248 7799 (Houston)
+1 408 638 0968 (San Jose)

Webinar ID: 920 8859 2008

If you experience technical difficulties with any of these dial-ins or if you need international dial-in numbers, please visit our website at https://investors.ginkgobioworks.com/events/ for updated dial-in information.

About Ginkgo Bioworks
Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo Biosecurity is building and deploying the next-generation infrastructure and technologies that global leaders need to predict, detect, and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and ginkgobiosecurity.com, read our blog, or follow us on social media channels such as X (@Ginkgo and @Ginkgo_Biosec), Instagram (@GinkgoBioworks), Threads (@GinkgoBioworks) or LinkedIn.

Forward-Looking Statements of Ginkgo Bioworks
This press release, the presentation, and the conference call and webcast contain certain forward-looking statements within the meaning of the federal securities laws, including statements regarding our plans, strategies, including with respect to our current expectations, operations and anticipated results of operations, both business and financial, including the timing for attaining Adjusted EBITDA breakeven and profitability, impacts of our restructuring, the potential financial impact of our facilities consolidation, potential customer success, including successful application of our offerings by our customers, and expectations with regard to revenue, expenses, including our stock-based compensation expenses, our full year 2025 outlook, and the market environment, all of which are subject to known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements, market trends, or industry results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements generally are identified by the words "believe," "can," "project," "potential," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this document, including but not limited to: (i) our ability to realize near-term and long-term cost savings associated with our site consolidation plans, including the ability to terminate leases or find sub-lease tenants for unused facilities, (ii) volatility in the price of Ginkgo's securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Ginkgo operates and plans to operate, variations in performance across competitors, and changes in laws and regulations affecting Ginkgo's business, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional business opportunities, including with respect to our solutions and tools offerings, (iv) the risk of downturns in demand for products using synthetic biology, (v) the uncertainty regarding the demand for passive monitoring programs and biosecurity services, (vi) changes to the biosecurity industry, including due to advancements in technology, emerging competition and evolution in industry demands, standards and regulations, (vii) the outcome of any pending or potential legal proceedings against Ginkgo, (viii) our ability to realize the expected benefits from and the success of our Foundry platform programs and Codebase assets, (ix) our ability to successfully develop engineered cells, bioprocesses, data packages or other deliverables, (x) the product development, production or manufacturing success of our customers, (xi) our exposure to the volatility and liquidity risks inherent in holding equity interests in other operating companies and other non-cash consideration we may receive for our services, (xii) the potential negative impact on our business of our restructuring or the failure to realize the anticipated savings associated therewith and (xiii) the uncertainty regarding government budgetary priorities and funding allocated to government agencies. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the "Risk Factors" section of Ginkgo's annual report on Form 10-K filed with the U.S. Securities and Exchange Commission (the "SEC") on February 25, 2025 and other documents filed by Ginkgo from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Ginkgo assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Ginkgo does not give any assurance that it will achieve its expectations.

Use of Non-GAAP Financial Measures
Certain of the financial measures included in this release, including Adjusted EBITDA, have not been prepared in accordance with generally accepted accounting principles ("GAAP"), and constitute "non-GAAP financial measures" as defined by the SEC. Ginkgo has included these non-GAAP financial measures because it believes they provide an additional tool for investors to use in evaluating Ginkgo's financial performance and prospects. Due to the nature and/or size of the items being excluded, such items do not reflect future gains, losses, expenses or benefits and are not indicative of our future operating performance. These non-GAAP financial measures are supplemental to, and should not be considered in isolation from, or as an alternative to, financial measures determined in accordance with GAAP. In addition, these non-GAAP financial measures may differ from non-GAAP financial measures with comparable names used by other companies. See the reconciliation below for additional information regarding certain of the non-GAAP financial measures included in this release, including a description of these non-GAAP financial measures and a reconciliation of the historic measures to Ginkgo's most comparable GAAP financial measures.

Ginkgo Bioworks Contacts:

INVESTOR CONTACT:
investors@ginkgobioworks.com

MEDIA CONTACT:
press@ginkgobioworks.com



     Ginkgo Bioworks Holdings, Inc.



     Consolidated Balance Sheets



     (in thousands, except per share data, unaudited)




                                                                   As of December 31, 2024 As of December 31, 2023



     
              
                Assets



     Current assets:



     Cash and cash equivalents                                                   $561,572                 $944,073



     Accounts receivable, net                                                      21,857                   17,157



     Accounts receivable - related parties                                            586                      742



     Prepaid expenses and other current assets                                     18,729                   39,777



     Total current assets                                                         602,744                1,001,749



     Property, plant and equipment, net                                           203,720                  188,193



     Operating lease right-of-use assets                                          394,435                  206,801



     Investments                                                                   48,704                   78,565



     Intangible assets, net                                                        72,510                   82,741



     Goodwill                                                                                              49,238



     Other non-current assets                                                      55,336                   58,055



     Total assets                                                              $1,377,449               $1,665,342



     
              
                Liabilities and Stockholders' Equity



     Current liabilities:



     Accounts payable                                                             $14,169                   $9,323



     Deferred revenue                                                              27,710                   44,486



     Accrued expenses and other current liabilities                                65,387                  110,051



     Total current liabilities                                                    107,266                  163,860



     Non-current liabilities:



     Deferred revenue, net of current portion                                      98,783                  158,062



     Operating lease liabilities, non-current                                     438,766                  221,835



     Other non-current liabilities                                                 16,576                   24,433



     Total liabilities                                                            661,391                  568,190



     Commitments and contingencies



     Stockholders' equity:



     Preferred stock, $0.0001 par value



     Common stock, $0.0001 par value                                                    5                        5



     Additional paid-in capital                                                 6,555,416                6,386,191



     Accumulated deficit                                                      (5,837,557)             (5,290,528)



     Accumulated other comprehensive (loss) income                                (1,806)                   1,484



     Total stockholders' equity                                                   716,058                1,097,152



     Total liabilities and stockholders' equity                                $1,377,449               $1,665,342



     Ginkgo Bioworks Holdings, Inc.



     Consolidated Statements of Operations and Comprehensive Loss



     (in thousands, except share data, unaudited)




                                                                                                                                       Three Months Ended December
                                                                                                                                        31,                                      Year Ended December 31,


                                                                                                           2024                   2023                2024                  2023



     Cell Engineering revenue                                                                          $34,789                $26,976            $173,972              $143,531



     Biosecurity revenue:



        Service                                                                                          9,058                  7,779              53,071                78,975



        Product                                                                                                                                                       28,949



     Total revenue                                                                                      43,847                 34,755             227,043               251,455



        Costs and operating expenses:



        Cost of Biosecurity service revenue                                                              7,553                  6,611              38,549                46,524



        Cost of Biosecurity product revenue                                                                                                                            7,481



        Cost of other revenue                                                                            2,069                                     5,999



        Research and development (1)                                                                    76,377                117,038             424,061               580,621



        General and administrative (1)                                                                  57,297                 89,223             246,161               385,025



        Impairment of lease assets                                                                                                                                    96,210



        Goodwill impairment                                                                                                                      47,858



        Restructuring charges                                                                            4,157                                    24,172



     Total operating expenses                                                                          147,453                212,872             786,800             1,115,861



     Loss from operations                                                                            (103,606)             (178,117)          (559,757)            (864,406)



     Other income (expense):



        Interest income                                                                                  7,247                 13,303              38,612                57,217



        Interest expense                                                                                   (4)                  (93)               (94)                 (93)



        Loss on equity method investments                                                                                    (1,119)                                 (2,635)



        Loss on investments                                                                           (12,545)              (10,012)           (28,827)             (54,827)



        Loss on deconsolidation of subsidiary                                                                               (42,502)            (7,013)             (42,502)



        Change in fair value of warrant liabilities                                                                            6,555               5,701                 5,168



        Other income, net                                                                                1,049                     93               3,870                 9,138



     Total other income (expense)                                                                      (4,253)              (33,775)             12,249              (28,534)



     Loss before income taxes                                                                        (107,859)             (211,892)          (547,508)            (892,940)



     Income tax benefit                                                                                  (325)                 (198)              (479)                 (71)



     Net loss                                                                                       $(107,534)            $(211,694)         $(547,029)           $(892,869)



     Net loss per share, basic and diluted                                                             $(2.00)               $(4.28)           $(10.54)             $(18.37)



     Weighted average common shares outstanding:



        Basic                                                                                       53,814,706             49,442,700          51,894,639            48,610,507



        Diluted                                                                                     53,814,706             49,471,075          51,894,639            48,610,507



     Comprehensive loss:



     Net loss                                                                                       $(107,534)            $(211,694)         $(547,029)           $(892,869)



     Other comprehensive (loss) income:



        Foreign currency translation adjustment                                                        (2,070)                 4,383             (4,782)                4,116



        Reclassification of foreign currency translation                                                                                          1,492


        adjustment realized upon sale of


        foreign subsidiary



     Total other comprehensive (loss) income                                                           (2,070)                 4,383             (3,290)                4,116



     Comprehensive loss                                                                             $(109,604)            $(207,311)         $(550,319)           $(888,753)





     (1)  Total stock-based compensation expense, inclusive of employer payroll taxes, was allocated as follows (in thousands):




                                                                                                                                       Three Months Ended December
                                                                                                                                        31,                                      Year Ended December 31,


                                                                                                           2024                   2023                2024                  2023



     Research and development                                                                           $9,695                $26,775             $57,723              $148,861



     General and administrative                                                                         10,968                 16,809              57,576                86,047



     Total                                                                                             $20,663                $43,584            $115,299              $234,908



     Ginkgo Bioworks Holdings, Inc.



     Consolidated Statements of Cash Flows



     (in thousands, unaudited)




                                                                                             Year Ended December 31,


                                                                                        2024          2023



     
                
                  Cash flows from operating activities:



     Net loss                                                                    $(547,029)   $(892,869)



     Adjustments to reconcile net loss to net cash used in operating activities:



     Depreciation and amortization                                                   63,020        70,507



     Stock-based compensation                                                       112,344       229,884



     Goodwill impairment                                                             47,858



     Restructuring related impairment charges                                         4,823



     Non-cash customer consideration                                                (1,117)      (1,373)



     Loss on equity method investments                                                             2,635



     Loss on investments                                                             28,827        54,827



     Change in fair value of notes receivable                                         2,014         2,416



     Change in fair value of warrant liabilities                                    (5,701)      (5,168)



     Change in fair value of contingent consideration liability                       3,214         9,168



     Loss on deconsolidation of subsidiary                                            7,013        42,502



     Impairment of long-lived assets                                                  5,796       121,404



     Deferred income tax benefit                                                      (936)        (801)



     Loss on disposal of equipment                                                      844           842



     Non-cash lease expense                                                          28,095        28,313



     Non-cash in-process research and development                                    19,796         9,182



     Other non-cash activity                                                          1,224         3,194



     Changes in operating assets and liabilities:



     Accounts receivable                                                            (4,725)       50,068



     Prepaid expenses and other current assets                                       10,085        10,473



     Operating lease right-of-use assets                                             23,463         9,275



     Other non-current assets                                                       (1,394)        2,570



            Accounts payable                                                          4,771       (1,183)



            Accrued expenses and other current liabilities                         (40,438)       16,899



     Deferred revenue, current and non-current                                     (68,645)     (35,917)



     Operating lease liabilities, current and non-current                          (14,881)     (22,800)



     Other non-current liabilities                                                    2,094           452



     Net cash used in operating activities                                        (319,585)    (295,500)



     
                
                  Cash flows from investing activities:



     Purchases of property and equipment                                           (62,541)     (40,801)



     Deconsolidation of subsidiaries - cash                                                     (42,980)



     Business acquisition                                                           (5,400)



     Purchase of notes receivable                                                                  (350)



     Proceeds from sales of marketable securities                                     4,519



     Proceeds from sale of equipment                                                    648         4,428



     Other                                                                              538         (990)



     Net cash used in investing activities                                         (62,236)     (80,693)



     
                
                  Cash flows from financing activities:



     Proceeds from exercise of stock options                                             84            93



     Taxes paid related to net share settlement of equity awards                                    (23)



     Principal payments on finance leases                                             (897)      (1,295)



     Contingent consideration payment                                                 (922)      (1,411)



     Other                                                                              (4)        (580)



     Net cash used in financing activities                                          (1,739)      (3,216)



     Effect of foreign exchange rates on cash and cash equivalents                    (281)        (588)



     Net decrease in cash, cash equivalents and restricted cash                   (383,841)    (379,997)





     Cash and cash equivalents, beginning of period                                 944,073     1,315,792



     Restricted cash, beginning of period                                            45,511        53,789



     Cash, cash equivalents and restricted cash, beginning of period                989,584     1,369,581





     Cash and cash equivalents, end of period                                       561,572       944,073



     Restricted cash, end of period                                                  44,171        45,511



     Cash, cash equivalents and restricted cash, end of period                     $605,743      $989,584



     Ginkgo Bioworks Holdings, Inc.



     Selected Non-GAAP Financial Measures



     (in thousands, unaudited)




                                                                         Three Months Ended December
                                                                          31,                                     Year Ended December 31,


                                                        2024        2023                2024                 2023



     Net loss (1)                                $(107,534) $(211,694)         $(547,029)          $(892,869)



     Interest income                                (7,247)   (13,226)           (38,612)            (57,217)



     Interest expense                                     4          15                  94                   93



     Income tax benefit                               (325)      (198)              (479)                (71)



     Depreciation and amortization                   15,652      12,837              63,020               70,507



     
                
                  EBITDA            (99,450)  (212,266)          (523,006)           (879,557)



     Stock-based compensation (2)                    20,663      43,584             115,299              234,908



     Impairment expense (3)                           5,796                         53,654              121,404



     Restructuring charges (4)                        4,157                         24,172



     Merger and acquisition related expenses (5)    (1,693)     18,062               4,417               61,189



     Loss on equity method investments                           1,119                                   2,635



     Loss on investments                             12,545      10,012              28,827               54,827



     Loss on deconsolidation of subsidiary                      42,502               7,013               42,502



     Change in fair value of warrant liabilities               (6,555)            (5,701)             (5,168)



     Change in fair value of convertible notes          887       2,174               2,014                2,295



     
                
                  Adjusted EBITDA  $(57,095) $(101,368)         $(293,311)          $(364,965)




     (1) All periods include non-cash revenue when earned, including $45.4 million in the year ended December 31, 2024, recognized pursuant to the termination of
            revenue contracts with Motif.





     (2) For the three months ended December 31, 2024 and 2023, includes $0.1 million and $0.8 million, respectively, in related employer payroll taxes. For the
            years ended December 31, 2024 and 2023, includes $3.0 million and $5.0 million, respectively, in related employer payroll taxes.





     (3) For the three months ended December 31, 2024, includes $5.8 million related to lab equipment. For the year ended December 31, 2024, includes $47.9 million
            related to goodwill impairment and $5.8 million related to lab equipment. For the year ended December 31, 2023, includes a $25.2 million impairment loss
            on lab equipment and a $96.2 million impairment loss on lease assets associated with an exited Zymergen leased facility.





     (4) Restructuring charges consist of employee termination costs from the reduction in force commenced in June 2024, as well as the impairment of a right-of-
            use asset relating to facilities consolidation.





     (5) Represents transaction and integration costs directly related to mergers and acquisitions, including: (i) due diligence, legal, consulting and accounting
            fees associated with acquisitions, (ii) post-acquisition employee retention bonuses and severance payments, (iii) the fair value adjustments to
            contingent consideration liabilities resulting from acquisitions, and (iv) costs associated with the Zymergen Bankruptcy, as well as securities
            litigation costs, net of insurance recovery. Not included in this adjustment are non-cash charges for acquired in-process research and development
            expenses, which totaled $5.2 million and zero for the three months ended December 31, 2024 and 2023, respectively, and $19.8 million and $9.6 million for
            the years ended December 31, 2024 and 2023, respectively.



     Ginkgo Bioworks Holdings, Inc.



     Segment Information



     (in thousands, unaudited)




                                                                                                                      Three Months Ended December
                                                                                                                       31,                                     Year Ended December 31,


                                                                                                     2024        2023                2024                 2023



     
                
                  Cell Engineering



     Revenue                                                                                     $34,789     $26,975            $173,972             $143,531



     Costs and operating expenses:



     Cost of other revenue                                                                         2,069                          5,999



     Research and development                                                                     50,364      72,951             271,512              335,943



     General and administrative                                                                   20,494      40,383             115,028              171,210



     Cell Engineering operating loss                                                            (38,138)   (86,359)          (218,567)           (363,622)



     
                
                  Biosecurity



     Service revenue                                                                               9,058       7,779              53,071               78,975



     Product revenue                                                                                   -                                            28,949



     Costs and operating expense:



     Cost of Biosecurity service revenue                                                           7,553       6,611              38,549               46,524



     Cost of Biosecurity product revenue                                                               -                                             7,481



     Research and development                                                                         52         192                 771                1,599



     General and administrative                                                                   11,200      12,652              44,370               55,514



     Biosecurity operating loss                                                                  (9,747)   (11,676)           (30,619)             (3,194)



     
                
                  Total segment operating loss                                   (47,885)   (98,035)          (249,186)           (366,816)



     Reconciling items to reconcile total segment operating loss to loss before income taxes:



     Stock-based compensation (1)                                                                 20,663      43,584             115,299              234,908



     Impairment expense (2)                                                                        5,796                         53,654              121,404



     Depreciation and amortization                                                                15,652      12,836              63,020               70,507



     Restructuring charges (3)                                                                     4,157                         24,172



     Carrying cost of excess space (net of sublease income) (4)                                    9,330                         25,986



     Merger and acquisition related expenses                                                     (1,693)     18,062               4,417               61,188



     Acquired in-process research and development                                                      -      5,601              19,849                9,582



     Other (income) expense, net (5)                                                               6,070      33,776             (8,075)              28,535



     
                
                  Loss before income taxes                                     $(107,860) $(211,894)         $(547,508)          $(892,940)




     (1) For the three months ended December 31, 2024 and 2023, includes $0.1 million and $0.8 million, respectively, in related employer payroll taxes. For the
            years ended December 31, 2024 and 2023, includes $3.0 million and $5.0 million, respectively, in related employer payroll taxes.





     (2) For the three months ended December 31, 2024, includes $5.8 million related to lab equipment. For the year ended December 31, 2024, includes $47.9 million
            related to goodwill impairment and $5.8 million related to lab equipment. For the year ended December 31, 2023, includes a $25.2 million impairment loss
            on lab equipment and a $96.2 million impairment loss on lease assets associated with an exited Zymergen leased facility.





     (3) Includes $4.2 million and $19.3 million in employee termination and other costs for the three months and year ended December 31, 2024, respectively.
            Additionally, Restructuring charges include $4.8 million in impairment of an operating lease right-of-use asset relating to facilities consolidation
            for the year ended December 31, 2024.





     (4) The carrying cost of excess space includes base rent, common area maintenance charges, and real estate taxes associated with facilities that are not
            occupied, net of any sublease income from these spaces.





     (5) Represents transaction and integration costs directly related to mergers and acquisitions, including: (i) due diligence, legal, consulting and accounting
            fees associated with acquisitions, (ii) post-acquisition employee retention bonuses and severance payments, (iii) the fair value adjustments to
            contingent consideration liabilities resulting from acquisitions, and (iv) costs associated with the Zymergen Bankruptcy, as well as securities
            litigation costs, net of insurance recovery.





     (6) Includes interest income, interest expense, loss on investments, losses/gains on deconsolidation of subsidiaries, changes in fair value of certain assets
            and liabilities, and other gains or losses.

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SOURCE Ginkgo Bioworks