Feb 16, 2018   SOURCE: PR NewsWire

Global Amyloidosis Market Spotlight 2017: Pfizer has Carried Out the Most Phase III Trials in Amyloidosis, Followed by Alnylam

DUBLIN, Feb. 16, 2018 /PRNewswire/ --

The "Market Spotlight: Amyloidosis" report has been added to ResearchAndMarkets.com's offering.

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This Market Spotlight report covers the amyloidosis market, comprising key pipeline and marketed drugs, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals.

Key Takeaways

    --  The author estimates that in 2016, there were approximately 59,000
        incident cases of amyloidosis worldwide, with the highest proportion
        being the primary (amyloid light-chain; AL) amyloidosis type.
    --  Among incident multiple myeloma cases, the author estimates there were
        approximately 14,600 cases of AL amyloidosis worldwide in 2016.
    --  Vyndaqel (tafamidis meglumine) is the only US Food and Drug
        Administration (FDA)-approved drug for transthyretin (TTR)- related
        hereditary amyloidosis (familial amyloid polyneuropathy).
    --  There are more industry-sponsored drugs in active clinical development
        for amyloidosis in Phase III than in any other phase. Therapies in
        development for amyloidosis focus on targets such as TTR, AL, cluster of
        differentiation (CD)38, proteasome, and serum amyloid P (SAP) component.
        The majority of therapies in development for amyloidosis are
        administered via the intravenous route, with the remainder being oral
        and subcutaneous formulations.
    --  High-impact upcoming events for drugs in the amyloidosis space include
        topline Phase III trial results for patisiran. There were seven
        licensing and asset acquisition activities involving amyloidosis drugs
        during 2012-17. The largest deal during that time was the $1,135m
        exclusive worldwide licensing and development agreement (in August 2012)
        between Janssen Biotech and Genmab, for the development and
        commercialization of Genmab's daratumumab and a backup human CD38
        antibody.
    --  The clinical trials distribution across Phases I-IV indicates that the
        majority of trials for amyloidosis have been in early and midphases of
        development, with 80% of trials in Phase I-II and only 20% in Phase
        III-IV.
    --  The US has a substantial lead in the number of amyloidosis clinical
        trials globally. The UK leads the major EU markets, while Japan has the
        top spot in Asia.
    --  Clinical trial activity in the amyloidosis space is dominated by
        completed trials. GlaxoSmithKline has the highest number of completed
        clinical trials for amyloidosis, with four.
    --  Pfizer has carried out the most Phase III trials in amyloidosis (with
        three), followed by Alnylam, which has sponsored one Phase III trial.

Key Topics Covered:

KEY TAKEAWAYS

DISEASE BACKGROUND
Amyloidosis subtypes

TREATMENT
Chemotherapy
Targeted therapy
Surgery
Bone marrow/stem cell transplantation
Palliative or supportive care

EPIDEMIOLOGY
Amyloidosis in multiple myeloma incidence methodology

MARKETED DRUGS
Approvals by country

PIPELINE DRUGS

KEY UPCOMING EVENTS

LICENSING AND ASSET ACQUISITION DEALS
GSK Passes On Taking Inotersen To FDA With Ionis
Fortress Subsidiary Licenses Amyloidosis Candidate From Columbia

PARENT PATENTS

CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase
APOLLO Success Clears Alnylam For Lift-Off
Ionis Touts Inotersen's Convenience As Phase III Safety Data Disappoint
Alnylam Plays Up Patisiran As Polyneuropathy Drug Nears Filings
Alnylam Ends Revusiran In Phase III, But Was Failure Due To Safety Or Efficacy?
Ionis Antisense Platform Safety Questioned After Thrombocytopenia Seen In Studies

BIBLIOGRAPHY

APPENDIX

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